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In previous research, we found\n                  <jats:italic>Myt1l<\/jats:italic>\n                  (a proneuronal transcription factor) mutations can cause precocious differentiation, neuronal immaturity, and transcriptomic alterations, including many in apoptotic regulators. Therefore, we used a recently developed\n                  <jats:italic>Myt1l<\/jats:italic>\n                  haploinsufficient mouse model to examine this gene\u2019s effects on ethanol-induced apoptosis across different developmental stages. We discovered that haploinsufficiency can moderately influence vulnerability to ethanol in a complex, age- and cell type-specific manner: apoptosis was reduced on P7, increased P21, but unaffected on P60. Remarkably, we also discovered the previously unrecognized ability of a single binge of ethanol to rapidly increase apoptosis within six hours in early adolescent and adult wild-type mice occurring in microglia and the newborn granule neurons in the hippocampus. This suggests apoptosis is an underappreciated contributor to ethanol\u2019s neuropathology at older ages and, translated to human use, occurs far more frequently than previously recognized.\n                <\/jats:p>","DOI":"10.1101\/2025.06.27.662020","type":"posted-content","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T22:20:16Z","timestamp":1751235616000},"source":"Crossref","is-referenced-by-count":0,"title":["A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the\n                  <i>Myt1l<\/i>\n                  gene"],"prefix":"10.64898","author":[{"given":"Nicole","family":"Fuhler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Tunzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Fotedar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-289X","authenticated-orcid":false,"given":"Rebecca","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran","family":"Prakasam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-4722","authenticated-orcid":false,"given":"Susan E.","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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