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The initial screen, performed in a large national health system, identified two antiprotozoals, atovaquone-proguanil and mefloquine, as being associated with increased survival. Matched exposed-unexposed cohorts were then constructed to validate mortality associations and examine incident outcomes, revealing reduced risks for diabetes, dementia, cardiovascular, renal, hepatic, pulmonary, and selected cancers, alongside increased risks for hearing loss, dry eye\/Sjogren\u2019s, and lichen planus. These patterns were externally replicated in the US TriNetX network, where similar associations were observed for atovaquone-proguanil, mefloquine, and nirmatrelvir-ritonavir. Because nirmatrelvir-ritonavir is prescribed to older, multimorbid individuals, its associations are unlikely to reflect healthy-traveler conditioning. The concordant protective and tissue-specific adverse associations across datasets and antiprotozoal drug classes support a testable hypothesis: short antiprotozoal courses may reduce aging-related morbidity by decreasing persistent protozoal burden, particularly\n                  <jats:italic>Toxoplasma gondii<\/jats:italic>\n                  .\n                <\/jats:p>","DOI":"10.1101\/2025.07.01.25330644","type":"posted-content","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:40:11Z","timestamp":1751557211000},"source":"Crossref","is-referenced-by-count":1,"title":["Antiprotozoal medications associated with increased longevity and reduced morbidity in two national cohorts"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-8896","authenticated-orcid":false,"given":"Ariel","family":"Israel","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical & Health Sciences, Tel Aviv University; Ramat Aviv, Tel Aviv 6997801, Israel"},{"name":"Leumit Research Institute, Leumit Health Services, 23 Sprinzak St., Tel Aviv 6473817, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9765-8938","authenticated-orcid":false,"given":"Abraham","family":"Weizman","sequence":"additional","affiliation":[{"name":"Research Unit, Geha Mental Health Center, Felsenstein Medical Research Center, and Sagol School of Neurosciences, Faculty of Medical & Health Sciences, Tel Aviv University, 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-0071","authenticated-orcid":false,"given":"Sarah","family":"Israel","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, P.O. 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