{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:27:06Z","timestamp":1785414426286,"version":"3.56.0"},"posted":{"date-parts":[[2025,7,6]]},"group-title":"Neuroscience","reference-count":0,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["Project ID 122679504 - SFB 874"],"award-info":[{"award-number":["Project ID 122679504 - SFB 874"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["JA 945\/5-1"],"award-info":[{"award-number":["JA 945\/5-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["Project number 492434978 - GRK 2862\/1, Subproject 10"],"award-info":[{"award-number":["Project number 492434978 - GRK 2862\/1, Subproject 10"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["BMBF, ERA-Net Neuron \u0093Horizon 2020\u0094, 01EW2104B"],"award-info":[{"award-number":["BMBF, ERA-Net Neuron \u0093Horizon 2020\u0094, 01EW2104B"]}]},{"name":"National Institutes of Health","award":["5U01NS099573"],"award-info":[{"award-number":["5U01NS099573"]}]},{"name":"Lee Kuan Yew Postdoctoral Fellowship","award":["022506-00001"],"award-info":[{"award-number":["022506-00001"]}]},{"award":["MOH-001720"],"award-info":[{"award-number":["MOH-001720"]}],"id":[{"id":"https:\/\/ror.org\/04x3cxs03","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,6]]},"abstract":"<jats:p>Visual perception appears largely stable in time. However, psychophysical studies have revealed that theta waves (4-8 Hz) can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of theta waves to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.<\/jats:p>","DOI":"10.1101\/2025.07.05.663288","type":"posted-content","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:05:15Z","timestamp":1751846715000},"source":"Crossref","is-referenced-by-count":1,"title":["Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-1151","authenticated-orcid":false,"given":"Callum M","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Azimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Staadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-6431","authenticated-orcid":false,"given":"Chenchen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5718-0765","authenticated-orcid":false,"given":"Thomas","family":"Knopfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-6259","authenticated-orcid":false,"given":"Dirk","family":"Jancke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.07.05.663288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:03:37Z","timestamp":1782277417000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.07.05.663288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1101\/2025.07.05.663288","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s42003-025-09492-9","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,7,6]]},"subtype":"preprint"}}