{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:11:23Z","timestamp":1785834683584,"version":"3.56.0"},"posted":{"date-parts":[[2025,7,11]]},"group-title":"Neurology","reference-count":54,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>We evaluated plasma biomarker association with, and classification accuracies for, A\u03b2-PET and cortical thickness in the biracial HCP-CoBRA cohort (53% B\/AA and 47% NHW).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In n=218 participants (age 62 [range: 57-71] years, 65% female and 15% A\u03b2 PET-positive), plasma biomarkers (p-tau181, p-tau217, p-tau231, GFAP, NfL, A\u03b242\/A\u03b240) were compared to A\u03b2-PET and MRI neuroimaging indicators.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>P-tau217 (Janssen and ALZpath [AUCs=0.915-0.919]) had high sensitivity and specificity (&gt;85%) for A\u03b2-PET status. All biomarkers except p-tau231 ruled out A\u03b2-pathology (NPV&gt;95%) but only Janssen p-tau217+ was good for confirmation (PPV=0.909). Plasma biomarkers performed poorly for predicting cortical thickness but were elevated according to joint A\u03b2-PET-neurodegeneration profiles. Biomarker accuracies for A\u03b2-PET positivity were unaffected by self-identified race, except ALZpath p-tau217(p=0.024). However, correlations with A\u03b2-PET varied by self-identified race.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>P-tau217 is a promising tool for Alzheimer\u2019s disease-related A\u03b2 pathology in older\/middle-aged individuals. However, apparent race-related performances should be further studied.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.07.10.25331312","type":"posted-content","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T23:50:13Z","timestamp":1752277813000},"source":"Crossref","is-referenced-by-count":2,"title":["Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study"],"prefix":"10.64898","author":[{"given":"Shayna T.","family":"Brodman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gallen","family":"Triana-Baltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gogola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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