{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:04:33Z","timestamp":1777352673457,"version":"3.51.4"},"posted":{"date-parts":[[2025,7,17]]},"group-title":"Neurology","reference-count":95,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Somatic symptom and related disorders (SSRD) are characterized by a mixture of neurological and psychiatric features and include functional neurological (FND) and somatic symptom disorders (SomD). While these complex neuropsychiatric disorders show evidence of genetic susceptibility, there are no genome-wide association studies (GWAS) of SSRD, and the heritability is unknown.<\/jats:p>\n                <jats:p>\n                  We did a GWAS of a total of 22,203 patients with SSRD, and 1,831,107 controls of European ancestry. We identified one genome-wide significant locus (chromosome 8:65565084) in SSRD, and one additional locus (chromosome 16:49074278) in the SomD subgroup (n cases = 18,536). The observed-scale SNP heritability was estimated to be 7.3 % for SSRD, 15.7 % for FND and 7.7 % for SomD. FND and SomD were strongly genetically correlated (rg=0.94, SE=0.11, p=3.9E-18). SSRD showed significant genetic correlation with psychiatric disorders (highest with anxiety, post-traumatic stress disorders, depression, rg=0.3- 0.8), neurological disorders (migraine, chronic pain, rg=0.4-0.6) and immune-related diseases (rg=0.2-0.3). Functional follow-up analysis of SSRD loci implicated the genes\n                  <jats:italic>CYP7B1, BHLHE22,<\/jats:italic>\n                  and\n                  <jats:italic>CBLN1,<\/jats:italic>\n                  which are involved in metabolic and brain-related processes, suggesting common underlying pathways.\n                <\/jats:p>\n                <jats:p>We identified genomic loci associations with SSRD and showed strong genetic correlation between FND and SomD and with neurological and psychiatric disorders, as well as immune-related diseases. The current findings highlight shared underlying pathophysiological processes between SSRD diagnostic categories.<\/jats:p>","DOI":"10.1101\/2025.07.16.25331639","type":"posted-content","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T23:05:13Z","timestamp":1752793513000},"source":"Crossref","is-referenced-by-count":2,"title":["Genome-wide study of somatic symptom and related disorders identifies novel genomic loci and map genetic architecture"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-2390","authenticated-orcid":false,"given":"Vera","family":"Fominykh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Jaholkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-250X","authenticated-orcid":false,"given":"Alexey 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