{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:59:33Z","timestamp":1785430773880,"version":"3.56.0"},"posted":{"date-parts":[[2025,7,26]]},"group-title":"Neuroscience","reference-count":36,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"award":["ZIA AA000455"],"award-info":[{"award-number":["ZIA AA000455"]}],"id":[{"id":"https:\/\/ror.org\/02jzrsm59","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Theta oscillations \u2013 rhythmic patterns of synchronous activity within discrete brain regions \u2013 are known to support memory, navigation, and behavioral coordination, and are sensitive to pharmacological manipulation. Acute ethanol (EtOH) exposure has been shown to alter theta oscillations, but its effects on transient theta bursts and cross- regional coordination during naturalistic behavior remain unclear. We recorded local field potentials (LFPs) from the medial septum (MS), hippocampal\n                  <jats:italic>Cornu Ammonis 1<\/jats:italic>\n                  (CA1), and medial prefrontal cortex (mPFC) in freely foraging mice following intraperitoneal injection of EtOH (1.5 g\/kg) or saline. We analyzed spectral power, theta burst dynamics, phase, and lag timing. Burst features from CA1 were used to train a machine learning classifier to predict session condition. EtOH impaired locomotion and reduced goal-directed behaviors, particularly early in the session. In CA1, theta power shifted toward lower frequencies and lagged coherence declined. EtOH increased the frequency but reduced the duration of theta bursts in CA1, and in MS, only burst count increased. EtOH enhanced the temporal alignment of MS\u2013CA1 burst pairs. Phase- locking between CA1 and MS during coupled bursts remained present but showed altered structure. Our classifier achieved robust performance using burst features such as skew and entropy, and reliably distinguished treatment conditions. EtOH modulates septohippocampal dynamics by altering the timing and structure of theta bursts. These results suggest that burst-level features are sensitive markers of EtOH\u2019s circuit-level effects during naturalistic behavior.\n                <\/jats:p>","DOI":"10.1101\/2025.07.22.666144","type":"posted-content","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T05:30:14Z","timestamp":1753594214000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute EtOH enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-2534","authenticated-orcid":false,"given":"Caleb B.","family":"Darden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan D.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-1955","authenticated-orcid":false,"given":"Andrew J.","family":"Kesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025072908251706000_2025.07.22.666144v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"2025072908251706000_2025.07.22.666144v1.2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2010.00015"},{"key":"2025072908251706000_2025.07.22.666144v1.3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000834"},{"key":"2025072908251706000_2025.07.22.666144v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.005"},{"key":"2025072908251706000_2025.07.22.666144v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2727"},{"key":"2025072908251706000_2025.07.22.666144v1.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008306107"},{"key":"2025072908251706000_2025.07.22.666144v1.7","doi-asserted-by":"crossref","unstructured":"Arkady Pikovsky, M.R. , J\u00fcrgen Kurths , Synchronization: A universal concept in nonlinear sciences. 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