{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:59:28Z","timestamp":1782280768108,"version":"3.54.5"},"posted":{"date-parts":[[2025,7,30]]},"group-title":"Neuroscience","reference-count":53,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["3R01MH121520-04S1"],"award-info":[{"award-number":["3R01MH121520-04S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Body size estimation\u2014the ability to judge the size and shape of one\u2019s own body\u2014 is a key perceptual component of body image. However, its neural basis, and the basis for inter-individual differences in accuracy, remain poorly understood, partly due to limitations in existing assessment tools.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We developed Somatomap 3D, an interactive fMRI-compatible task allowing participants to manipulate a rotatable 3D avatar by adjusting the size and shape of 26 individual body parts to match their perceived body. Twenty-eight healthy male and female adults completed the task during fMRI. Brain activity in a priori regions of interest from previous studies of body processing was modeled using a general linear model incorporating event-specific parameters and parametric modulators related to task performance. Inter-individual differences in body size estimation accuracy were calculated using multidimensional scaling of body part estimation errors, and scores were correlated with BOLD signal eigenvariates from regions of interest.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Task engagement was associated with significant activation in hypothesized body-selective and multisensory regions, including bilateral extrastriate body area, right fusiform body area, right superior parietal lobule, and bilateral premotor cortex. Multidimensional scaling identified a primary subdimension reflecting distortions in body part girths, which was significantly associated with neural responses in the superior parietal lobule. No other brain regions showed significant associations with inter-individual differences in estimation accuracy.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results suggest that body size estimation engages a distributed network of visual, motor, and parietal regions. Among these, only the superior parietal lobule showed a significant association with inter-individual variation in body size estimation accuracy for body part girths, supporting its role as a candidate neural substrate for altered body representation in psychiatric conditions such as eating disorders and body dysmorphic disorder.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.07.24.666647","type":"posted-content","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:15:17Z","timestamp":1753920917000},"source":"Crossref","is-referenced-by-count":0,"title":["Functional Brain Mapping of Body Size Estimation Using a 3D Avatar"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6078-2970","authenticated-orcid":false,"given":"Hayden J.","family":"Peel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-6830","authenticated-orcid":false,"given":"Joel P.","family":"Diaz-Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-4810","authenticated-orcid":false,"given":"Sameena","family":"Karsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-4131","authenticated-orcid":false,"given":"Rajay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-7704","authenticated-orcid":false,"given":"Gerhard","family":"Hellemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-345X","authenticated-orcid":false,"given":"Jamie D.","family":"Feusner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025080109100726000_2025.07.24.666647v1.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2612-04.2005"},{"key":"2025080109100726000_2025.07.24.666647v1.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4698-14.2015"},{"key":"2025080109100726000_2025.07.24.666647v1.3","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw219"},{"key":"2025080109100726000_2025.07.24.666647v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199709)22:2<107::AID-EAT1>3.0.CO;2-J"},{"key":"2025080109100726000_2025.07.24.666647v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2012.06.006"},{"issue":"1","key":"2025080109100726000_2025.07.24.666647v1.6","first-page":"1","article-title":"Body size estimation in women with anorexia nervosa and healthy controls using 3D avatars","volume":"7","year":"2017","journal-title":"Scientific Reports"},{"key":"2025080109100726000_2025.07.24.666647v1.7","unstructured":"de Leeuw, J. (1977). Application of Convex Analysis to Multidimensional Scaling. Recent Developments in Statistics."},{"key":"2025080109100726000_2025.07.24.666647v1.8","doi-asserted-by":"publisher","DOI":"10.1080\/17588928.2011.582945"},{"key":"2025080109100726000_2025.07.24.666647v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"2025080109100726000_2025.07.24.666647v1.10","doi-asserted-by":"publisher","DOI":"10.1002\/erv.622"},{"key":"2025080109100726000_2025.07.24.666647v1.11","unstructured":"Fechner, G . (1966). Elements of psychophysics. Vol. I. New York."},{"key":"2025080109100726000_2025.07.24.666647v1.12","unstructured":"Feusner, J. , & Cazzato, V . (n.d.). Body Image. In E. by C. E. Wierenga & J. E. Steinglass (Eds.), The Handbook of the Neurobiology of Eating Disorders. Oxford University Press."},{"key":"2025080109100726000_2025.07.24.666647v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.012"},{"key":"2025080109100726000_2025.07.24.666647v1.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164450."},{"key":"2025080109100726000_2025.07.24.666647v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.06.029"},{"key":"2025080109100726000_2025.07.24.666647v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.05.003"},{"key":"2025080109100726000_2025.07.24.666647v1.17","doi-asserted-by":"crossref","unstructured":"Groe, K. , Calahong, B. , Diaz-Fong, J. P. , Karsan, S. , & Feusner, J. (2025). Twenty-Six Body Measurements for the Somatomap App. https:\/\/www.protocols.io\/view\/twenty-six-body-measurements-for-the-somatomap-app-c8zvzx66","DOI":"10.17504\/protocols.io.j8nlkoqzwv5r\/v1"},{"key":"2025080109100726000_2025.07.24.666647v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2497"},{"key":"2025080109100726000_2025.07.24.666647v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114349"},{"key":"2025080109100726000_2025.07.24.666647v1.20","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn036"},{"key":"2025080109100726000_2025.07.24.666647v1.21","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22135"},{"key":"2025080109100726000_2025.07.24.666647v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.006"},{"key":"2025080109100726000_2025.07.24.666647v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2024.152529"},{"key":"2025080109100726000_2025.07.24.666647v1.24","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v031.i03"},{"key":"2025080109100726000_2025.07.24.666647v1.25","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v102.i10"},{"key":"2025080109100726000_2025.07.24.666647v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.023"},{"key":"2025080109100726000_2025.07.24.666647v1.27","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy238"},{"key":"2025080109100726000_2025.07.24.666647v1.28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2637-19.2020"},{"key":"2025080109100726000_2025.07.24.666647v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101691"},{"key":"2025080109100726000_2025.07.24.666647v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.09.001"},{"key":"2025080109100726000_2025.07.24.666647v1.31","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991826"},{"key":"2025080109100726000_2025.07.24.666647v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2017.08.005"},{"key":"2025080109100726000_2025.07.24.666647v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/nn1641"},{"key":"2025080109100726000_2025.07.24.666647v1.34","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/97961"},{"key":"2025080109100726000_2025.07.24.666647v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.032"},{"key":"2025080109100726000_2025.07.24.666647v1.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2010.02.012"},{"key":"2025080109100726000_2025.07.24.666647v1.37","doi-asserted-by":"publisher","DOI":"10.1101\/2023.06.14.23291397"},{"key":"2025080109100726000_2025.07.24.666647v1.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90739-w"},{"issue":"10","key":"2025080109100726000_2025.07.24.666647v1.39","doi-asserted-by":"crossref","first-page":"e14115","DOI":"10.2196\/14115","article-title":"A Novel Mobile Tool (Somatomap) to Assess Body Image Perception Pilot Tested With Fashion Models and Nonmodels: Cross-Sectional Study","volume":"6","year":"2019","journal-title":"JMIR Mental Health"},{"key":"2025080109100726000_2025.07.24.666647v1.40","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1133367"},{"key":"2025080109100726000_2025.07.24.666647v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2706"},{"key":"2025080109100726000_2025.07.24.666647v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3069"},{"key":"2025080109100726000_2025.07.24.666647v1.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.065"},{"key":"2025080109100726000_2025.07.24.666647v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl131"},{"key":"2025080109100726000_2025.07.24.666647v1.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.06.001"},{"key":"2025080109100726000_2025.07.24.666647v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/nn1815"},{"key":"2025080109100726000_2025.07.24.666647v1.47","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.090048"},{"key":"2025080109100726000_2025.07.24.666647v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.11.011"},{"key":"2025080109100726000_2025.07.24.666647v1.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.06.007"},{"key":"2025080109100726000_2025.07.24.666647v1.50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00561.2020"},{"key":"2025080109100726000_2025.07.24.666647v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.11.011"},{"key":"2025080109100726000_2025.07.24.666647v1.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.06.007"},{"key":"2025080109100726000_2025.07.24.666647v1.53","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00561.2020"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.07.24.666647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:06:01Z","timestamp":1782277561000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.07.24.666647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1101\/2025.07.24.666647","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1038\/s41598-026-38383-0","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,7,30]]},"subtype":"preprint"}}