{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:26:50Z","timestamp":1786663610442,"version":"build-2736575974"},"posted":{"date-parts":[[2025,7,30]]},"group-title":"Neuroscience","reference-count":98,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>The development of multicellular organisms requires proper interplays between cell-autonomous genetic programs controlled by combinations of transcription factors that regulate the differentiation of distinct cell populations and non-cell autonomous processes that coordinate the proliferation, the fate, the survival, the respective location, and the proper interactions of these populations. During the development of the nervous system, non-cell autonomous mechanisms determine neuronal fate, survival, distribution, axon guidance, and connectivity. Although similar processes are suggested to be at work in the formation of spinal motor circuits, the molecular mechanisms involved remain mostly elusive. Here, we provide evidence that the Onecut transcription factors regulate a non-cell autonomous mechanism that modulate pre-motor interneuron development. We show that conditional inactivation of the Onecut factors in spinal motor neurons affects the differentiation and the positioning of pre-motor interneuron populations. We identify that Neurotrophin-3 produced by motor neurons under the control of the Onecut factors non-cell autonomously regulate the production and the distribution of pre-motor interneuron populations. Thus, we elucidated one of the non-cell autonomous mechanisms that coordinate the formation of the spinal motor circuits.<\/jats:p>","DOI":"10.1101\/2025.07.27.665825","type":"posted-content","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:15:18Z","timestamp":1753866918000},"source":"Crossref","is-referenced-by-count":0,"title":["Neurotrophin-3 produced by motor neurons non-cell autonomously regulates the development of pre-motor interneurons in the developing spinal cord"],"prefix":"10.64898","author":[{"given":"Andrea","family":"Angla-Navarro","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, Louvain Institute of Biomolecular Science and Technology, LIBST, Animal Molecular and Cellular Biology (AMCB), Place Croix du Sud 5, 1348 Louvain la Neuve, Belgium"},{"name":"Universit\u00e9 catholique de Louvain, Institute of Neuroscience, IoNS, Laboratory of Neural Differentiation (NEDI), avenue Hippocrate 55, 1200 Woluwe-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-7181","authenticated-orcid":false,"given":"Ana","family":"Dominguez Bajo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, Louvain Institute of Biomolecular Science and Technology, LIBST, Animal Molecular and Cellular Biology (AMCB), Place Croix du Sud 5, 1348 Louvain la Neuve, Belgium"},{"name":"Universit\u00e9 catholique de Louvain, Institute of Neuroscience, IoNS, Laboratory of Neural Differentiation (NEDI), avenue Hippocrate 55, 1200 Woluwe-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Toch","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, Institute of Neuroscience, IoNS, Laboratory of Neural Differentiation (NEDI), avenue Hippocrate 55, 1200 Woluwe-Saint-Lambert, 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