{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:13:42Z","timestamp":1791353622961,"version":"4.3.1"},"posted":{"date-parts":[[2025,8,2]]},"group-title":"Genomics","reference-count":66,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R01AI173557"],"award-info":[{"award-number":["R01AI173557"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["K24AI134990"],"award-info":[{"award-number":["K24AI134990"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI075045"],"award-info":[{"award-number":["R01AI075045"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"publisher"}]},{"award":["U19AI089674"],"award-info":[{"award-number":["U19AI089674"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI117001"],"award-info":[{"award-number":["R01AI117001"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01AI139179"],"award-info":[{"award-number":["R01AI139179"]}],"id":[{"id":"https:\/\/ror.org\/043z4tv69","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"crossref","award":["RD\/15\/0001"],"award-info":[{"award-number":["RD\/15\/0001"]}],"id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"crossref","award":["INV-035751"],"award-info":[{"award-number":["INV-035751"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Malaria control in Uganda is threatened by the emergence of artemisinin partial resistance and reduced lumefantrine susceptibility. To identify loci contributing to decreased drug susceptibility, we assessed signatures of selection in Ugandan whole-genome\n                  <jats:italic>Plasmodium falciparum<\/jats:italic>\n                  sequences. Extended shared haplotypes were seen for Kelch13 C469Y and A675V mutations, but the strongest signal of recent selection was centered on a segment of chromosome 7 encoding the phosphoinositide-binding protein (PX1, PF3D7_0720700). A haplotype, represented by three PX1 mutations (L1222P, M1701I, D1705N) and two deletions (designated PIN), was first seen in 2008 and rapidly increased, reaching prevalence &gt;50% in northern Uganda by 2016 and eastern Uganda by 2023. PIN-carrying parasites showed significantly decreased\n                  <jats:italic>ex vivo<\/jats:italic>\n                  susceptibilities to lumefantrine, mefloquine and dihydroartemisinin. A parasite strain in which\n                  <jats:italic>px1<\/jats:italic>\n                  was disrupted\n                  <jats:italic>in vitro<\/jats:italic>\n                  showed increased susceptibility to the three drugs. Thus, PX1 polymorphisms appear to impact on the susceptibilities of African malaria parasites to key drugs.\n                <\/jats:p>","DOI":"10.1101\/2025.07.30.667738","type":"posted-content","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:30:13Z","timestamp":1754155813000},"source":"Crossref","is-referenced-by-count":17,"title":["A novel locus associated with decreased susceptibility of\n                  <i>Plasmodium falciparum<\/i>\n                  to lumefantrine and dihydroartemisinin has emerged and spread in Uganda"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-9508","authenticated-orcid":false,"given":"Karamoko","family":"Niar\u00e9","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA"},{"name":"Center for Computational Molecular Biology, Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bersabeh","family":"Tafesse","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayland","family":"Treat","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Sadler","sequence":"additional","affiliation":[{"name":"Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Okitwi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Orena","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Asua","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Kreutzfeld","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Legac","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Marglous","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.","family":"Nsobya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adoke","family":"Yeka","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Department of Disease Control and Environmental Health, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Ferdig","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angana","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Juliano","sequence":"additional","affiliation":[{"name":"Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA"},{"name":"Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC, USA"},{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-8204","authenticated-orcid":false,"given":"Jeffrey A.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA"},{"name":"Center for Computational Molecular Biology, Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-8030","authenticated-orcid":false,"given":"Melissa D.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA"},{"name":"Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026070703550819000_2025.07.30.667738v2.1","unstructured":"World malaria report 2025. https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2025."},{"key":"2026070703550819000_2025.07.30.667738v2.2","doi-asserted-by":"crossref","unstructured":"Shibeshi, W. , Alemkere, G. , Mulu, A. & Engidawork, E . Efficacy and safety of artemisinin-based combination therapies for the treatment of uncomplicated malaria in pediatrics: a systematic review and meta-analysis. BMC Infect. Dis. 21, 326 (2021).","DOI":"10.1186\/s12879-021-06018-6"},{"key":"2026070703550819000_2025.07.30.667738v2.3","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-1"},{"key":"2026070703550819000_2025.07.30.667738v2.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(01)00140-1"},{"key":"2026070703550819000_2025.07.30.667738v2.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"2026070703550819000_2025.07.30.667738v2.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70252-4"},{"key":"2026070703550819000_2025.07.30.667738v2.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"2026070703550819000_2025.07.30.667738v2.8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw388"},{"key":"2026070703550819000_2025.07.30.667738v2.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260403"},{"key":"2026070703550819000_2025.07.30.667738v2.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006930"},{"key":"2026070703550819000_2025.07.30.667738v2.11","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s42003-024-07178-2","article-title":"Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation","volume":"7","year":"2024","journal-title":"Commun. Biol"},{"key":"2026070703550819000_2025.07.30.667738v2.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax4735"},{"key":"2026070703550819000_2025.07.30.667738v2.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01008-2"},{"key":"2026070703550819000_2025.07.30.667738v2.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211803)"},{"key":"2026070703550819000_2025.07.30.667738v2.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1005-2"},{"key":"2026070703550819000_2025.07.30.667738v2.16","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.29.24306442"},{"key":"2026070703550819000_2025.07.30.667738v2.17","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.07.23298207"},{"key":"2026070703550819000_2025.07.30.667738v2.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2210956"},{"key":"2026070703550819000_2025.07.30.667738v2.19","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/s41564-023-01461-4","article-title":"Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia","volume":"8","year":"2023","journal-title":"Nat. Microbiol"},{"key":"2026070703550819000_2025.07.30.667738v2.20","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00362-1"},{"key":"2026070703550819000_2025.07.30.667738v2.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33873-x"},{"key":"2026070703550819000_2025.07.30.667738v2.22","doi-asserted-by":"publisher","DOI":"10.1101\/2024.12.31.24319821"},{"key":"2026070703550819000_2025.07.30.667738v2.23","doi-asserted-by":"crossref","unstructured":"Okitwi, M. et al. Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019\u20132024. Nat. Commun. 16, (2025).","DOI":"10.1038\/s41467-025-62810-x"},{"key":"2026070703550819000_2025.07.30.667738v2.24","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0031"},{"key":"2026070703550819000_2025.07.30.667738v2.25","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaf155"},{"key":"2026070703550819000_2025.07.30.667738v2.26","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/S2666-5247(21)00085-9","article-title":"Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study","volume":"2","year":"2021","journal-title":"Lancet Microbe"},{"key":"2026070703550819000_2025.07.30.667738v2.27","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0339"},{"key":"2026070703550819000_2025.07.30.667738v2.28","doi-asserted-by":"crossref","unstructured":"Kubota, R. , Ishino, T. , Iwanaga, S. & Shinzawa, N . Evaluation of the effect of gene duplication by genome editing on drug resistance in Plasmodium falciparum. Front. Cell. Infect. Microbiol. 12, 915656 (2022).","DOI":"10.3389\/fcimb.2022.915656"},{"key":"2026070703550819000_2025.07.30.667738v2.29","doi-asserted-by":"crossref","unstructured":"Laird, V. R. et al. Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after anti-malarial treatment. Malar. J. 24, 186 (2025).","DOI":"10.1186\/s12936-025-05248-2"},{"key":"2026070703550819000_2025.07.30.667738v2.30","doi-asserted-by":"publisher","DOI":"10.1086\/503423"},{"key":"2026070703550819000_2025.07.30.667738v2.31","doi-asserted-by":"crossref","unstructured":"Rasmussen, S. A. et al. Changing antimalarial drug sensitivities in Uganda. Antimicrob. Agents Chemother. 61, (2017).","DOI":"10.1128\/AAC.01516-17"},{"key":"2026070703550819000_2025.07.30.667738v2.32","doi-asserted-by":"crossref","unstructured":"Ebong, C. et al. Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria and prevalence of molecular markers associated with artemisinin and partner drug resistance in Uganda. Malar. J. 20, 484 (2021).","DOI":"10.1186\/s12936-021-04021-5"},{"key":"2026070703550819000_2025.07.30.667738v2.33","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.5226564"},{"key":"2026070703550819000_2025.07.30.667738v2.34","doi-asserted-by":"crossref","first-page":"e0165923","DOI":"10.1128\/aac.01659-23","article-title":"Indigenous emergence and spread of kelch13 C469Y artemisinin-resistant Plasmodium falciparum in Uganda","volume":"68","year":"2024","journal-title":"Antimicrob. Agents Chemother"},{"key":"2026070703550819000_2025.07.30.667738v2.35","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa687"},{"key":"2026070703550819000_2025.07.30.667738v2.36","doi-asserted-by":"crossref","unstructured":"Niar\u00e9, K. , Greenhouse, B. & Bailey, J. A . An optimized GATK4 pipeline for Plasmodium falciparum whole genome sequencing variant calling and analysis. Malar. J. 22, 207 (2023).","DOI":"10.1186\/s12936-023-04632-0"},{"key":"2026070703550819000_2025.07.30.667738v2.37","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/s41564-023-01377-z","article-title":"Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1","volume":"8","year":"2023","journal-title":"Nat Microbiol"},{"key":"2026070703550819000_2025.07.30.667738v2.38","doi-asserted-by":"crossref","first-page":"e0323921","DOI":"10.1128\/mbio.03239-21","article-title":"A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum","volume":"13","year":"2022","journal-title":"MBio"},{"key":"2026070703550819000_2025.07.30.667738v2.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07588-x"},{"key":"2026070703550819000_2025.07.30.667738v2.40","doi-asserted-by":"crossref","unstructured":"Ravenhall, M. et al. Characterizing the impact of sustained sulfadoxine\/pyrimethamine use upon the Plasmodium falciparum population in Malawi. Malar. J. 15, 575 (2016).","DOI":"10.1186\/s12936-016-1634-6"},{"key":"2026070703550819000_2025.07.30.667738v2.41","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu349"},{"key":"2026070703550819000_2025.07.30.667738v2.42","doi-asserted-by":"crossref","unstructured":"Hathaway, N. J. et al. Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3. Elife 13, (2024).","DOI":"10.7554\/eLife.93534"},{"key":"2026070703550819000_2025.07.30.667738v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51701-2"},{"key":"2026070703550819000_2025.07.30.667738v2.44","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msad082"},{"key":"2026070703550819000_2025.07.30.667738v2.45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009576"},{"key":"2026070703550819000_2025.07.30.667738v2.46","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu106"},{"key":"2026070703550819000_2025.07.30.667738v2.47","unstructured":"MalariaGEN et al. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples. Wellcome Open Res 6, 42 (2021)."},{"key":"2026070703550819000_2025.07.30.667738v2.48","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad724"},{"key":"2026070703550819000_2025.07.30.667738v2.49","doi-asserted-by":"crossref","unstructured":"Sutherland, C. J. et al. Pfk13-independent treatment failure in four imported cases of Plasmodium falciparum malaria treated with artemether-lumefantrine in the United Kingdom. Antimicrob. Agents Chemother. 61, (2017).","DOI":"10.1128\/AAC.02382-16"},{"key":"2026070703550819000_2025.07.30.667738v2.50","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taaf013"},{"key":"2026070703550819000_2025.07.30.667738v2.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007279"},{"key":"2026070703550819000_2025.07.30.667738v2.52","doi-asserted-by":"crossref","unstructured":"Espi\u00e9, E. et al. Efficacy of fixed-dose combination artesunate-amodiaquine versus artemether-lumefantrine for uncomplicated childhood Plasmodium falciparum malaria in Democratic Republic of Congo: a randomized non-inferiority trial. Malar. J. 11, 174 (2012).","DOI":"10.1186\/1475-2875-11-174"},{"key":"2026070703550819000_2025.07.30.667738v2.53","doi-asserted-by":"crossref","unstructured":"Ferrari, G. et al. An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo: the MATIAS study. Malar. J. 14, 226 (2015).","DOI":"10.1186\/s12936-015-0732-1"},{"key":"2026070703550819000_2025.07.30.667738v2.54","doi-asserted-by":"crossref","unstructured":"Asua, V. et al. Changing molecular markers of antimalarial drug sensitivity across Uganda. Antimicrob. Agents Chemother. 63, (2019).","DOI":"10.1128\/AAC.01818-18"},{"key":"2026070703550819000_2025.07.30.667738v2.55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020190"},{"key":"2026070703550819000_2025.07.30.667738v2.56","doi-asserted-by":"publisher","DOI":"10.1086\/647946"},{"key":"2026070703550819000_2025.07.30.667738v2.57","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu353"},{"key":"2026070703550819000_2025.07.30.667738v2.58","doi-asserted-by":"crossref","unstructured":"Oyola, S. O. et al. Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification. Malar. J. 15, 597 (2016).","DOI":"10.1186\/s12936-016-1641-7"},{"key":"2026070703550819000_2025.07.30.667738v2.59","doi-asserted-by":"publisher","DOI":"10.1101\/gr.203711.115"},{"key":"2026070703550819000_2025.07.30.667738v2.60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005348"},{"key":"2026070703550819000_2025.07.30.667738v2.61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts115"},{"key":"2026070703550819000_2025.07.30.667738v2.62","doi-asserted-by":"publisher","DOI":"10.1093\/BIOINFORMATICS\/BTX011"},{"key":"2026070703550819000_2025.07.30.667738v2.63","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6386707"},{"key":"2026070703550819000_2025.07.30.667738v2.64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092500"},{"key":"2026070703550819000_2025.07.30.667738v2.65","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.03.24302209"},{"key":"2026070703550819000_2025.07.30.667738v2.66","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-210x.2012.00261.x"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.07.30.667738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:55:44Z","timestamp":1783421744000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.07.30.667738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,2]]},"references-count":66,"URL":"https:\/\/doi.org\/10.1101\/2025.07.30.667738","relation":{},"subject":[],"published":{"date-parts":[[2025,8,2]]},"subtype":"preprint"}}