{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:34:22Z","timestamp":1790620462600,"version":"4.1.0"},"posted":{"date-parts":[[2025,8,23]]},"group-title":"Bioengineering","reference-count":85,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"National Cancer Institute","award":["UG3CA275681"],"award-info":[{"award-number":["UG3CA275681"]}]},{"name":"National Cancer Institute","award":["U54CA268083"],"award-info":[{"award-number":["U54CA268083"]}]},{"name":"National Cancer Institute","award":["RO1CA300052"],"award-info":[{"award-number":["RO1CA300052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>The human endometrium is a dynamic tissue that lines the uterus and undergoes constant remodeling, making it especially susceptible to gynecological diseases like endometriosis and endometrial cancer. The molecular mechanisms of these conditions are not well understood, partly due to the lack of in vitro models that mimic endometrial physiology, which limits options for targeted intervention and treatment of these diseases. Mouse models are also inadequate, as common laboratory strains do not naturally undergo a menstrual cycle comparable to that of humans. This study addresses this need by developing a 3D multi-compartment assembloid that mimics the architecture of endometrial tissue and recapitulates all three phases of the menstrual cycle (proliferative, secretory, and menstrual regression) within a single platform. The cellular and extracellular matrix (ECM) components in each compartment are carefully tuned based on a 3D spatial cellular map of endometrial tissue. The model contains endometrial epithelial cells enveloped in a basement membrane and endometrial stromal cells in a surrounding collagen-rich layer; this architecture allows realistic interactions between these cells and their respective ECMs. This assembloid successfully supports the controlled growth and organization of these cells, revealing reciprocal regulation of cell behavior and exhibiting compartment-specific hormonal responses, i.e., stromal decidualization. This platform enables the study of dynamic, phase-resolved, and compartment-specific paracrine signaling in human endometrial biology. By combining tissue-informed design, modular fabrication, and full-cycle hormonal responsiveness, this model sets a new benchmark for blastocyst implantation studies, organ modeling, and precision diagnostics in human reproductive health.<\/jats:p>","DOI":"10.1101\/2025.08.22.671545","type":"posted-content","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:30:16Z","timestamp":1755937816000},"source":"Crossref","is-referenced-by-count":1,"title":["3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7097-5830","authenticated-orcid":false,"given":"Kehan A.","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7150-2513","authenticated-orcid":false,"given":"Victoria","family":"Duarte-Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6740-8977","authenticated-orcid":false,"given":"Xin","family":"Di Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1795-9769","authenticated-orcid":false,"given":"Bryan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5115-2293","authenticated-orcid":false,"given":"Andr\u00e9","family":"Forjaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-0113","authenticated-orcid":false,"given":"Ashleigh J.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen M.","family":"Alicea-Rebecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-4743","authenticated-orcid":false,"given":"Praful","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-4038","authenticated-orcid":false,"given":"Eban A","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-3045","authenticated-orcid":false,"given":"Denis","family":"Wirtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025082600451246000_2025.08.22.671545v1.1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.7150\/ijbs.89795","article-title":"Endometrial Stem Cells: Orchestrating Dynamic Regeneration of Endometrium and Their Implications in Diverse Endometrial Disorders","volume":"20","year":"2024","journal-title":"Int J Biol Sci"},{"key":"2025082600451246000_2025.08.22.671545v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00248-3"},{"key":"2025082600451246000_2025.08.22.671545v1.3","first-page":"1","article-title":"Endometriosis","volume":"4","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2025082600451246000_2025.08.22.671545v1.4","unstructured":"Endometriosis. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/endometriosis."},{"key":"2025082600451246000_2025.08.22.671545v1.5","unstructured":"H. Mahdy , E. S. Vadakekut , D. Crotzer , \u201cEndometrial Cancer\u201d in StatPearls (StatPearls Publishing, Treasure Island (FL), 2025; http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK525981\/)."},{"key":"2025082600451246000_2025.08.22.671545v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.116"},{"key":"2025082600451246000_2025.08.22.671545v1.7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41572-021-00324-8","article-title":"Endometrial cancer","volume":"7","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2025082600451246000_2025.08.22.671545v1.8","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/1573404813666161221164810","article-title":"Future Directions in Endometriosis Research and Therapeutics","volume":"14","year":"2018","journal-title":"Curr Womens Health Rev"},{"key":"2025082600451246000_2025.08.22.671545v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0565-5"},{"key":"2025082600451246000_2025.08.22.671545v1.10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41574-022-00725-z","article-title":"Strategies for modelling endometrial diseases","volume":"18","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"2025082600451246000_2025.08.22.671545v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01026-x"},{"key":"2025082600451246000_2025.08.22.671545v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0259-3"},{"key":"2025082600451246000_2025.08.22.671545v1.13","doi-asserted-by":"crossref","unstructured":"A. Forjaz , E. Vaz , V. M. Romero , S. Joshi , V. Queiroga , A. M. Braxton , A. C. Jiang , K. Fujikura , T. Cornish , S.-M. Hong , R. H. Hruban , P.-H. Wu , L. D. Wood , A. L. Kiemen , D. Wirtz , Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues. Cell Reports Methods 5 (2025).","DOI":"10.1016\/j.crmeth.2025.101075"},{"key":"2025082600451246000_2025.08.22.671545v1.14","unstructured":"Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium | Nature Cell Biology. https:\/\/www.nature.com\/articles\/ncb3516."},{"key":"2025082600451246000_2025.08.22.671545v1.15","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.medj.2023.07.004","article-title":"Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk","volume":"4","year":"2023","journal-title":"Med"},{"key":"2025082600451246000_2025.08.22.671545v1.16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69603"},{"key":"2025082600451246000_2025.08.22.671545v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83645-8"},{"key":"2025082600451246000_2025.08.22.671545v1.18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/clinem\/dgz100","article-title":"Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome","volume":"105","year":"2020","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"2025082600451246000_2025.08.22.671545v1.19","doi-asserted-by":"crossref","unstructured":"S. G. Zambuto , K. B. H. Clancy , B. A. C. Harley , A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion. Interface Focus 9, 20190016 (2019).","DOI":"10.1098\/rsfs.2019.0016"},{"key":"2025082600451246000_2025.08.22.671545v1.20","doi-asserted-by":"publisher","DOI":"10.3791\/60384"},{"key":"2025082600451246000_2025.08.22.671545v1.21","doi-asserted-by":"crossref","unstructured":"E. Franc\u00e9s-Herrero , E. Ju\u00e1rez-Barber , H. Campo , S. L\u00f3pez-Mart\u00ednez , L. de Miguel-G\u00f3mez , A. Faus , A. Pellicer , H. Ferrero , I. Cervell\u00f3 , Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium. Journal of Personalized Medicine 11, 504 (2021).","DOI":"10.3390\/jpm11060504"},{"key":"2025082600451246000_2025.08.22.671545v1.22","doi-asserted-by":"crossref","unstructured":"Y. Hibaoui , A. Feki , Organoid Models of Human Endometrial Development and Disease. Front Cell Dev Biol 8, 84 (2020).","DOI":"10.3389\/fcell.2020.00084"},{"key":"2025082600451246000_2025.08.22.671545v1.23","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0428"},{"key":"2025082600451246000_2025.08.22.671545v1.24","doi-asserted-by":"crossref","unstructured":"S. De Vriendt , C. M. Casares , S. Rocha , H. Vankelecom , Matrix scaffolds for endometrium-derived organoid models. Front. Endocrinol. 14 (2023).","DOI":"10.3389\/fendo.2023.1240064"},{"key":"2025082600451246000_2025.08.22.671545v1.25","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3390\/cells9051121","article-title":"Organoids of Human Endometrium: A Powerful In Vitro Model for the Endometrium-Embryo Cross-Talk at the Implantation Site","volume":"9","year":"2020","journal-title":"Cells"},{"key":"2025082600451246000_2025.08.22.671545v1.26","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1016\/j.bioactmat.2021.04.006","article-title":"Endometrial membrane organoids from human embryonic stem cell combined with the 3D Matrigel for endometrium regeneration in asherman syndrome","volume":"6","year":"2021","journal-title":"Bioactive Materials"},{"key":"2025082600451246000_2025.08.22.671545v1.27","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-21-0023"},{"key":"2025082600451246000_2025.08.22.671545v1.28","doi-asserted-by":"crossref","unstructured":"S.-R. Park , S.-R. Kim , J. B. Im , C. H. Park , H.-Y. Lee , I.-S. Hong , 3D stem cell-laden artificial endometrium: successful endometrial regeneration and pregnancy. Biofabrication 13, 045012 (2021).","DOI":"10.1088\/1758-5090\/ac165a"},{"key":"2025082600451246000_2025.08.22.671545v1.29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab186"},{"key":"2025082600451246000_2025.08.22.671545v1.30","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2020.0022"},{"key":"2025082600451246000_2025.08.22.671545v1.31","doi-asserted-by":"crossref","unstructured":"S. Muruganandan , X. Fan , S. Dhal , N. R. Nayak , Development of A 3D Tissue Slice Culture Model for the Study of Human Endometrial Repair and Regeneration. Biomolecules 10, 136 (2020).","DOI":"10.3390\/biom10010136"},{"key":"2025082600451246000_2025.08.22.671545v1.32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.actbio.2022.12.016","article-title":"3D bio-printed endometrial construct restores the full-thickness morphology and fertility of injured uterine endometrium","volume":"157","year":"2023","journal-title":"Acta Biomaterialia"},{"key":"2025082600451246000_2025.08.22.671545v1.33","doi-asserted-by":"crossref","unstructured":"M. Yamaguchi , K. Yoshihara , N. Yachida , K. Suda , R. Tamura , T. Ishiguro , T. Enomoto , The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium. Journal of Personalized Medicine 11, 713 (2021).","DOI":"10.3390\/jpm11080713"},{"key":"2025082600451246000_2025.08.22.671545v1.34","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa183"},{"key":"2025082600451246000_2025.08.22.671545v1.35","doi-asserted-by":"crossref","unstructured":"X. Li , S. P. Kodithuwakku , R. W. S. Chan , W. S. B. Yeung , Y. Yao , E. H. Y. Ng , P. C. N. Chiu , C.-L. Lee , Three-dimensional culture models of human endometrium for studying trophoblast-endometrium interaction during implantation. Reproductive Biology and Endocrinology 20, 120 (2022).","DOI":"10.1186\/s12958-022-00973-8"},{"key":"2025082600451246000_2025.08.22.671545v1.36","doi-asserted-by":"crossref","unstructured":"C. M. Klapperich , G. Vunjak-Novakovic , J. Robinson , R. Horton , P. K. Kreeger , M. Mahmoudi , S. Shah , A. Frolova , Bioengineering solutions to improve women\u2019s health. Med 6 (2025).","DOI":"10.1016\/j.medj.2025.100699"},{"key":"2025082600451246000_2025.08.22.671545v1.37","doi-asserted-by":"crossref","unstructured":"Y. Abbas , L. G. Brunel , M. S. Hollinshead , R. C. Fernando , L. Gardner , I. Duncan , A. Moffett , S. Best , M. Y. Turco , G. J. Burton , R. E. Cameron , Generation of a three-dimensional collagen scaffold-based model of the human endometrium. Interface Focus 10, 20190079 (2020).","DOI":"10.1098\/rsfs.2019.0079"},{"key":"2025082600451246000_2025.08.22.671545v1.38","doi-asserted-by":"crossref","unstructured":"A. D. van den Brand , E. Rubinstein , P. C. de Jong , M. van den Berg , M. B. M. van Duursen , Primary endometrial 3D co-cultures: A comparison between human and rat endometrium. The Journal of Steroid Biochemistry and Molecular Biology 194, 105458 (2019).","DOI":"10.1016\/j.jsbmb.2019.105458"},{"key":"2025082600451246000_2025.08.22.671545v1.39","doi-asserted-by":"crossref","unstructured":"J. R. H. Wendel , X. Wang , L. J. Smith , S. M. Hawkins , Three-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment. Biomedicines 8, 525 (2020).","DOI":"10.3390\/biomedicines8110525"},{"key":"2025082600451246000_2025.08.22.671545v1.40","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gar064"},{"key":"2025082600451246000_2025.08.22.671545v1.41","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3516"},{"key":"2025082600451246000_2025.08.22.671545v1.42","doi-asserted-by":"publisher","DOI":"10.1242\/dev.148478"},{"key":"2025082600451246000_2025.08.22.671545v1.43","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.medj.2023.07.004","article-title":"Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk","volume":"4","year":"2023","journal-title":"Med"},{"key":"2025082600451246000_2025.08.22.671545v1.44","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-21-0023"},{"key":"2025082600451246000_2025.08.22.671545v1.45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mattod.2022.07.006","article-title":"Multi-compartment tumor organoids","volume":"61","year":"2022","journal-title":"Materials Today"},{"key":"2025082600451246000_2025.08.22.671545v1.46","doi-asserted-by":"crossref","unstructured":"S. Joshi , A. Forjaz , K. S. Han , Y. Shen , V. Queiroga , F. A. Selaru , M. G\u00e9rard , D. Xenes , J. Matelsky , B. Wester , A. M. Barrutia , A. L. Kiemen , P.-H. Wu , D. Wirtz , InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping. Nat Methods, 1\u201312 (2025).","DOI":"10.1101\/2024.03.07.583909"},{"key":"2025082600451246000_2025.08.22.671545v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07359-3"},{"key":"2025082600451246000_2025.08.22.671545v1.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01650-9"},{"key":"2025082600451246000_2025.08.22.671545v1.49","doi-asserted-by":"crossref","unstructured":"A. J. Crawford , A. Forjaz , J. Bons , I. Bhorkar , T. Roy , D. Schell , V. Queiroga , K. Ren , D. Kramer , W. Huang , G. C. Russo , M.-H. Lee , P.-H. Wu , I.-M. Shih , T.-L. Wang , M. A. Atkinson , B. Schilling , A. L. Kiemen , D. Wirtz , Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube. Science Advances 10, eadp6285 (2024).","DOI":"10.1126\/sciadv.adp6285"},{"key":"2025082600451246000_2025.08.22.671545v1.50","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.08.658506"},{"key":"2025082600451246000_2025.08.22.671545v1.51","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0160-8"},{"key":"2025082600451246000_2025.08.22.671545v1.52","doi-asserted-by":"crossref","first-page":"dev199577","DOI":"10.1242\/dev.199577","article-title":"Cyclical endometrial repair and regeneration","volume":"148","year":"2021","journal-title":"Development"},{"key":"2025082600451246000_2025.08.22.671545v1.53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1039\/c6ib00245e","article-title":"Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function","volume":"9","year":"2017","journal-title":"Integrative Biology"},{"key":"2025082600451246000_2025.08.22.671545v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83645-8"},{"key":"2025082600451246000_2025.08.22.671545v1.55","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.836"},{"key":"2025082600451246000_2025.08.22.671545v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-03007-2"},{"key":"2025082600451246000_2025.08.22.671545v1.57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16416-0"},{"key":"2025082600451246000_2025.08.22.671545v1.58","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00673-1"},{"key":"2025082600451246000_2025.08.22.671545v1.59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806783105"},{"key":"2025082600451246000_2025.08.22.671545v1.60","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070152"},{"key":"2025082600451246000_2025.08.22.671545v1.61","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3390\/jpm12071048","article-title":"Modeling Endometrium Biology and Disease","volume":"12","year":"2022","journal-title":"J Pers Med"},{"key":"2025082600451246000_2025.08.22.671545v1.62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2496"},{"key":"2025082600451246000_2025.08.22.671545v1.63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/rmb2.12088","article-title":"Decidualization of the human endometrium","volume":"17","year":"2018","journal-title":"Reproductive Medicine and Biology"},{"key":"2025082600451246000_2025.08.22.671545v1.64","first-page":"2235","article-title":"Morphophysical dynamics of human endometrial cells during decidualization. Nanomedicine: Nanotechnology","volume":"14","year":"2018","journal-title":"Biology and Medicine"},{"key":"2025082600451246000_2025.08.22.671545v1.65","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12088"},{"key":"2025082600451246000_2025.08.22.671545v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.027"},{"key":"2025082600451246000_2025.08.22.671545v1.67","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.4.502"},{"key":"2025082600451246000_2025.08.22.671545v1.68","doi-asserted-by":"crossref","unstructured":"M. Van Wynendaele , C. Thieffry , L. Samain , C. E. Pierreux , D. Tyteca , E. Marbaix , P. Henriet , Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell culture. Steroids 198, 109284 (2023).","DOI":"10.1016\/j.steroids.2023.109284"},{"key":"2025082600451246000_2025.08.22.671545v1.69","unstructured":"Gadd45a growth arrest and DNA-damage-inducible 45 alpha [Mus musculus (house mouse)] - Gene - NCBI. https:\/\/www.ncbi.nlm.nih.gov\/gene\/13197."},{"key":"2025082600451246000_2025.08.22.671545v1.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2011.08.002"},{"key":"2025082600451246000_2025.08.22.671545v1.71","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.febslet.2014.02.043","article-title":"Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization","volume":"588","year":"2014","journal-title":"FEBS Lett"},{"key":"2025082600451246000_2025.08.22.671545v1.72","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.1.258"},{"key":"2025082600451246000_2025.08.22.671545v1.73","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41374-020-0411-x","article-title":"Altered glycosylation of glycodelin in endometrial carcinoma","volume":"100","year":"2020","journal-title":"Lab Invest"},{"key":"2025082600451246000_2025.08.22.671545v1.74","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1530\/RAF-22-0002","article-title":"Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss","volume":"3","year":"2022","journal-title":"Reprod Fertil"},{"key":"2025082600451246000_2025.08.22.671545v1.75","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.020651"},{"key":"2025082600451246000_2025.08.22.671545v1.76","doi-asserted-by":"crossref","unstructured":"G. A. Johnson , R. C. Burghardt , F. W. Bazer , Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. Journal of Animal Science and Biotechnology 5, 56 (2014).","DOI":"10.1186\/2049-1891-5-56"},{"key":"2025082600451246000_2025.08.22.671545v1.77","doi-asserted-by":"crossref","first-page":"e0148381","DOI":"10.1371\/journal.pone.0148381","article-title":"Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor","volume":"11","year":"2016","journal-title":"PLOS ONE"},{"key":"2025082600451246000_2025.08.22.671545v1.78","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2019"},{"key":"2025082600451246000_2025.08.22.671545v1.79","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.27.586980"},{"key":"2025082600451246000_2025.08.22.671545v1.80","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3516"},{"key":"2025082600451246000_2025.08.22.671545v1.81","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880050"},{"key":"2025082600451246000_2025.08.22.671545v1.82","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-193334"},{"key":"2025082600451246000_2025.08.22.671545v1.83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915389116"},{"key":"2025082600451246000_2025.08.22.671545v1.84","doi-asserted-by":"crossref","unstructured":"S. Altm\u00e4e , M. Koel , U. V\u00f5sa , P. Adler , M. Suhorut\u0161enko , T. Laisk-Podar , V. Kukushkina , M. Saare , A. Velthut-Meikas , K. Krjut\u0161kov , L. Aghajanova , P. G. Lalitkumar , K. Gemzell-Danielsson , L. Giudice , C. Sim\u00f3n , A. Salumets , Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers. Sci Rep 7, 10077 (2017).","DOI":"10.1038\/s41598-017-10098-3"},{"key":"2025082600451246000_2025.08.22.671545v1.85","doi-asserted-by":"crossref","unstructured":"Z. Yu , P. Huang , L. Wang , F. Meng , Q. Shi , X. Huang , L. Qiu , H. Wang , S. Kong , J. Wu , Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development. BMC Biology 22, 166 (2024).","DOI":"10.1186\/s12915-024-01966-2"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.08.22.671545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:23:42Z","timestamp":1768469022000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.08.22.671545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":85,"URL":"https:\/\/doi.org\/10.1101\/2025.08.22.671545","relation":{},"subject":[],"published":{"date-parts":[[2025,8,23]]},"subtype":"preprint"}}