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We examined the cellular basis for synaptic vulnerability in the auditory system, where three subtypes of spiral ganglion neurons (SGNs)\u2014Ia, Ib, and Ic\u2014carry acoustic information from the cochlea to the brain. In response to noise and aging, a subset of synapses between inner hair cells and SGNs are lost, but it is unclear how this loss varies across SGN subtypes. Using genetic labelling, we showed that Ia SGNs have larger post-synaptic densities (PSDs) than Ib and Ic SGNs and are the most resilient subtype. Ia PSD volumes increased with age and were unchanged after noise exposure. By contrast, average Ib\/Ic PSD volumes did not change with age but decreased with noise. Genetic reprogramming of Ib\/Ic neurons to a Ia-like identity provided significant protection against noise-induced synaptopathy, linking identity to resilience and providing an entry point for therapeutics.<\/jats:p>","DOI":"10.1101\/2025.08.27.672747","type":"posted-content","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:05:18Z","timestamp":1756742718000},"source":"Crossref","is-referenced-by-count":2,"title":["Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice"],"prefix":"10.64898","author":[{"given":"Joy A.","family":"Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor G.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Merrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8600","authenticated-orcid":false,"given":"Lisa V.","family":"Goodrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025090408401679000_2025.08.27.672747v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01576-w"},{"key":"2025090408401679000_2025.08.27.672747v1.2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22392"},{"key":"2025090408401679000_2025.08.27.672747v1.3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41582-025-01094-7","article-title":"Synapse vulnerability and resilience across the clinical spectrum of dementias","volume":"21","year":"2025","journal-title":"Nat Rev Neurol"},{"key":"2025090408401679000_2025.08.27.672747v1.4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3644-16.2017"},{"key":"2025090408401679000_2025.08.27.672747v1.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914247117"},{"key":"2025090408401679000_2025.08.27.672747v1.6","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023114587"},{"key":"2025090408401679000_2025.08.27.672747v1.7","doi-asserted-by":"publisher","DOI":"10.1121\/1.381736"},{"key":"2025090408401679000_2025.08.27.672747v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.007"},{"key":"2025090408401679000_2025.08.27.672747v1.9","doi-asserted-by":"crossref","unstructured":"Petitpr\u00e9, C. et al. 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