{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:58:02Z","timestamp":1785416282420,"version":"3.56.0"},"posted":{"date-parts":[[2025,9,10]]},"group-title":"Immunology","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R15GM117503"],"award-info":[{"award-number":["R15GM117503"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R15DK127440"],"award-info":[{"award-number":["R15DK127440"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Psoriasis is a chronic skin disease that results in scaly patches and affects 2-3% of people worldwide. Therapeutic treatment targets the TNF-\u03b1\/IL-17 axis to disrupt keratinocyte hyperproliferation and inflammation. While more is known about the role of dermal \u03b1\u00df and \u03b3\u03b4 T cells in IL-17 production, less is understood about the role of resident epidermal T cells. Here, we examine how TNF-\u03b1 modulates epidermal \u03b3\u03b4 T cell activation and function. We show that a subset of activated epidermal \u03b3\u03b4 T cells expresses TNFR2 with or without TNFR1. Stimulation with TNF-\u03b1 induces epidermal \u03b3\u03b4 T cells to produce IL-17 family cytokines and chemokines. Epidermal \u03b3\u03b4 T cells do not require TNFR1 or 2 for development or homing to the skin. Instead, TNFR2 plays roles in epidermal \u03b3\u03b4 T cell function skewing them toward a T\u03b3\u03b417 phenotype during psoriasis. Investigation of the mechanisms by which TNF-\u03b1 associated inflammation impacts epidermal \u03b3\u03b4 T cell function may help identify new cellular targets for immunotherapy or mark them as early regulators of skin inflammation.<\/jats:p>","DOI":"10.1101\/2025.09.05.674535","type":"posted-content","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:45:11Z","timestamp":1757515511000},"source":"Crossref","is-referenced-by-count":0,"title":["TNFR2 is Expressed by a Discrete Subset of Epidermal \u03b3\u03b4 T Cells with an IL-17 Gene Signature during Psoriasis"],"prefix":"10.64898","author":[{"given":"Jasmine","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Rhoiney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-4066","authenticated-orcid":false,"given":"Julie M.","family":"Jameson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025091308550748000_2025.09.05.674535v1.1","unstructured":"Organisation mondiale de la sant\u00e9, editor. 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