{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:01:34Z","timestamp":1782280894246,"version":"3.54.5"},"posted":{"date-parts":[[2025,9,16]]},"group-title":"Molecular Biology","reference-count":132,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"NSF","award":["DMR-2128556"],"award-info":[{"award-number":["DMR-2128556"]}]},{"name":"NIH","award":["NS139178"],"award-info":[{"award-number":["NS139178"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Conformational variations in \u03b1-syn fibrils are thought to underlie the distinct clinical features of synucleinopathies, including Lewy body dementia (LBD), Parkinsons\u2019s disease (PD), and multiple system atrophy (MSA), suggesting that distinct fibril structures act as molecular fingerprints linked to disease phenotype. While the origins of these conformational variations remain unclear, increasing evidence points to membranes as key modulators of fibrils conformations. In this study, we investigated how age-related alterations in membrane composition and fluidity influence \u03b1-syn fibril formation and cellular outcomes. Using complex mixture membranes that mimic normal neuronal membranes and their age-related modifications in fatty acid chains, we found that \u03b1-syn fibrils grown with these membranes displayed distinct 2D ssNMR spectral patterns compared to lipid-free \u03b1-syn fibrils, reflecting differences in rigid fibril cores. Moreover, fibrils grown with age-related membranes exhibited weaker membrane association than those grown with normal neuronal membranes. These membrane-associated fibrils induce stronger neuronal pathologies than lipid-free fibrils, though the severity differed in intraneuronal aggregation and inflammation responses. Overall, our findings provide new insights into how age-related changes in membrane composition shape \u03b1-syn fibril structure and pathogenicity, strengthening the link between membrane dynamics and amyloid-driven neurodegeneration.<\/jats:p>","DOI":"10.1101\/2025.09.10.675439","type":"posted-content","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:45:16Z","timestamp":1758041116000},"source":"Crossref","is-referenced-by-count":0,"title":["Lipid Acyl Chain-Driven \u03b1-Synuclein Fibril Polymorphisms and Neuronal Pathologies"],"prefix":"10.64898","author":[{"given":"Yoongyeong","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Chemistry, Drexel University, Philadelphia, PA 19104, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Alim","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY 13902, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY 13902, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Olabi","sequence":"additional","affiliation":[{"name":"Department of Biology, Drexel University, Philadelphia, PA 19104, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungwook","family":"Paek","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Binghamton University, Binghamton, NY 13902, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9230-0446","authenticated-orcid":false,"given":"Myungwoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Drexel University, Philadelphia, PA 19104, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026021807501089000_2025.09.10.675439v3.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9"},{"key":"2026021807501089000_2025.09.10.675439v3.2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4827"},{"key":"2026021807501089000_2025.09.10.675439v3.3","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"2026021807501089000_2025.09.10.675439v3.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6469"},{"key":"2026021807501089000_2025.09.10.675439v3.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00407-8"},{"key":"2026021807501089000_2025.09.10.675439v3.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-021-00829-y"},{"key":"2026021807501089000_2025.09.10.675439v3.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"2026021807501089000_2025.09.10.675439v3.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.26"},{"key":"2026021807501089000_2025.09.10.675439v3.9","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070931"},{"key":"2026021807501089000_2025.09.10.675439v3.10","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101419"},{"key":"2026021807501089000_2025.09.10.675439v3.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0104-4"},{"key":"2026021807501089000_2025.09.10.675439v3.12","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-023-00342-4"},{"key":"2026021807501089000_2025.09.10.675439v3.13","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.737195"},{"key":"2026021807501089000_2025.09.10.675439v3.14","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8208"},{"key":"2026021807501089000_2025.09.10.675439v3.15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212382"},{"key":"2026021807501089000_2025.09.10.675439v3.16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b01042"},{"key":"2026021807501089000_2025.09.10.675439v3.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094469"},{"key":"2026021807501089000_2025.09.10.675439v3.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.008"},{"key":"2026021807501089000_2025.09.10.675439v3.19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31790-7"},{"key":"2026021807501089000_2025.09.10.675439v3.20","doi-asserted-by":"publisher","DOI":"10.1039\/c4cp05563b"},{"key":"2026021807501089000_2025.09.10.675439v3.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167859"},{"key":"2026021807501089000_2025.09.10.675439v3.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002780"},{"key":"2026021807501089000_2025.09.10.675439v3.23","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4736"},{"key":"2026021807501089000_2025.09.10.675439v3.24","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00819"},{"key":"2026021807501089000_2025.09.10.675439v3.25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305326200"},{"key":"2026021807501089000_2025.09.10.675439v3.26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093301"},{"key":"2026021807501089000_2025.09.10.675439v3.27","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00579"},{"key":"2026021807501089000_2025.09.10.675439v3.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.11.007"},{"key":"2026021807501089000_2025.09.10.675439v3.29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195227"},{"key":"2026021807501089000_2025.09.10.675439v3.30","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.035493"},{"key":"2026021807501089000_2025.09.10.675439v3.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0423-2"},{"key":"2026021807501089000_2025.09.10.675439v3.32","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.181989"},{"key":"2026021807501089000_2025.09.10.675439v3.33","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00579"},{"key":"2026021807501089000_2025.09.10.675439v3.34","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171103"},{"key":"2026021807501089000_2025.09.10.675439v3.35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601899113"},{"key":"2026021807501089000_2025.09.10.675439v3.36","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1750"},{"key":"2026021807501089000_2025.09.10.675439v3.37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210136200"},{"key":"2026021807501089000_2025.09.10.675439v3.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2019.02.003"},{"key":"2026021807501089000_2025.09.10.675439v3.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102565"},{"key":"2026021807501089000_2025.09.10.675439v3.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2018.09.012"},{"key":"2026021807501089000_2025.09.10.675439v3.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.12.011"},{"key":"2026021807501089000_2025.09.10.675439v3.42","doi-asserted-by":"publisher","DOI":"10.1021\/ja405993r"},{"key":"2026021807501089000_2025.09.10.675439v3.43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.2c00283"},{"key":"2026021807501089000_2025.09.10.675439v3.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34552-7"},{"key":"2026021807501089000_2025.09.10.675439v3.45","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00314"},{"key":"2026021807501089000_2025.09.10.675439v3.46","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00671"},{"key":"2026021807501089000_2025.09.10.675439v3.47","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300003R"},{"key":"2026021807501089000_2025.09.10.675439v3.48","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg2174"},{"key":"2026021807501089000_2025.09.10.675439v3.49","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490010106"},{"key":"2026021807501089000_2025.09.10.675439v3.50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021604623208"},{"key":"2026021807501089000_2025.09.10.675439v3.51","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00527-1"},{"key":"2026021807501089000_2025.09.10.675439v3.52","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101204"},{"key":"2026021807501089000_2025.09.10.675439v3.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108132"},{"key":"2026021807501089000_2025.09.10.675439v3.54","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90550-6"},{"key":"2026021807501089000_2025.09.10.675439v3.55","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0260"},{"key":"2026021807501089000_2025.09.10.675439v3.56","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(95)00079-8"},{"key":"2026021807501089000_2025.09.10.675439v3.57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00725"},{"key":"2026021807501089000_2025.09.10.675439v3.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2614(01)00791-6"},{"key":"2026021807501089000_2025.09.10.675439v3.59","doi-asserted-by":"publisher","DOI":"10.1021\/ja047919t"},{"key":"2026021807501089000_2025.09.10.675439v3.60","doi-asserted-by":"publisher","DOI":"10.1021\/ja017001r"},{"key":"2026021807501089000_2025.09.10.675439v3.61","doi-asserted-by":"publisher","DOI":"10.1021\/ja972655e"},{"key":"2026021807501089000_2025.09.10.675439v3.62","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13772"},{"key":"2026021807501089000_2025.09.10.675439v3.63","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.3690"},{"key":"2026021807501089000_2025.09.10.675439v3.64","doi-asserted-by":"publisher","DOI":"10.1021\/ja804517m"},{"key":"2026021807501089000_2025.09.10.675439v3.65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809232106"},{"key":"2026021807501089000_2025.09.10.675439v3.66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507624200"},{"key":"2026021807501089000_2025.09.10.675439v3.67","doi-asserted-by":"publisher","DOI":"10.1080\/19336896.2019.1704612"},{"key":"2026021807501089000_2025.09.10.675439v3.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.057"},{"key":"2026021807501089000_2025.09.10.675439v3.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.03.008"},{"key":"2026021807501089000_2025.09.10.675439v3.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.02.013"},{"key":"2026021807501089000_2025.09.10.675439v3.71","doi-asserted-by":"publisher","DOI":"10.1063\/1.1680061"},{"key":"2026021807501089000_2025.09.10.675439v3.72","doi-asserted-by":"publisher","DOI":"10.1063\/1.470372"},{"key":"2026021807501089000_2025.09.10.675439v3.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.048"},{"key":"2026021807501089000_2025.09.10.675439v3.74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19512-3"},{"key":"2026021807501089000_2025.09.10.675439v3.75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506109102"},{"key":"2026021807501089000_2025.09.10.675439v3.76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806270105"},{"key":"2026021807501089000_2025.09.10.675439v3.77","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04010"},{"key":"2026021807501089000_2025.09.10.675439v3.78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009542"},{"key":"2026021807501089000_2025.09.10.675439v3.79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501430112"},{"key":"2026021807501089000_2025.09.10.675439v3.80","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00523"},{"key":"2026021807501089000_2025.09.10.675439v3.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2018.03.008"},{"key":"2026021807501089000_2025.09.10.675439v3.82","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01061-1"},{"key":"2026021807501089000_2025.09.10.675439v3.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.038"},{"key":"2026021807501089000_2025.09.10.675439v3.84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152339799"},{"key":"2026021807501089000_2025.09.10.675439v3.85","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2201020"},{"key":"2026021807501089000_2025.09.10.675439v3.86","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0149-0"},{"key":"2026021807501089000_2025.09.10.675439v3.87","first-page":"1086","article-title":"SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson\u2019s disease","volume":"123","year":"2010","journal-title":"Chin Med J (Engl"},{"key":"2026021807501089000_2025.09.10.675439v3.88","doi-asserted-by":"publisher","DOI":"10.1038\/s44172-025-00581-5"},{"key":"2026021807501089000_2025.09.10.675439v3.89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03442-1"},{"key":"2026021807501089000_2025.09.10.675439v3.90","doi-asserted-by":"publisher","DOI":"10.3791\/53193"},{"key":"2026021807501089000_2025.09.10.675439v3.91","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62493-5"},{"key":"2026021807501089000_2025.09.10.675439v3.92","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200110134"},{"key":"2026021807501089000_2025.09.10.675439v3.93","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00755-0"},{"key":"2026021807501089000_2025.09.10.675439v3.94","doi-asserted-by":"publisher","DOI":"10.2174\/157015906778520782"},{"key":"2026021807501089000_2025.09.10.675439v3.95","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.001015"},{"key":"2026021807501089000_2025.09.10.675439v3.96","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-006-9053-9"},{"key":"2026021807501089000_2025.09.10.675439v3.97","doi-asserted-by":"publisher","DOI":"10.2174\/187152712800792758"},{"key":"2026021807501089000_2025.09.10.675439v3.98","doi-asserted-by":"publisher","DOI":"10.5607\/en23007"},{"key":"2026021807501089000_2025.09.10.675439v3.99","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21937-3"},{"key":"2026021807501089000_2025.09.10.675439v3.100","doi-asserted-by":"publisher","DOI":"10.3390\/life11050431"},{"key":"2026021807501089000_2025.09.10.675439v3.101","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00478"},{"key":"2026021807501089000_2025.09.10.675439v3.102","doi-asserted-by":"publisher","DOI":"10.3390\/cells12071083"},{"key":"2026021807501089000_2025.09.10.675439v3.103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109617119"},{"key":"2026021807501089000_2025.09.10.675439v3.104","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00159"},{"key":"2026021807501089000_2025.09.10.675439v3.105","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002566"},{"key":"2026021807501089000_2025.09.10.675439v3.106","doi-asserted-by":"publisher","DOI":"10.1172\/jci39088"},{"key":"2026021807501089000_2025.09.10.675439v3.107","doi-asserted-by":"publisher","DOI":"10.1038\/ncb748"},{"key":"2026021807501089000_2025.09.10.675439v3.108","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0482-05.2005"},{"key":"2026021807501089000_2025.09.10.675439v3.109","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8267-8"},{"key":"2026021807501089000_2025.09.10.675439v3.110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126517"},{"key":"2026021807501089000_2025.09.10.675439v3.111","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0143-07.2008"},{"key":"2026021807501089000_2025.09.10.675439v3.112","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/216298"},{"key":"2026021807501089000_2025.09.10.675439v3.113","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00147-2"},{"key":"2026021807501089000_2025.09.10.675439v3.114","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00077"},{"key":"2026021807501089000_2025.09.10.675439v3.115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.585703"},{"key":"2026021807501089000_2025.09.10.675439v3.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.10.009"},{"key":"2026021807501089000_2025.09.10.675439v3.117","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08622-7"},{"key":"2026021807501089000_2025.09.10.675439v3.118","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3194"},{"key":"2026021807501089000_2025.09.10.675439v3.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.07.056"},{"key":"2026021807501089000_2025.09.10.675439v3.120","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5269"},{"key":"2026021807501089000_2025.09.10.675439v3.121","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002461"},{"key":"2026021807501089000_2025.09.10.675439v3.122","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.9.1242"},{"key":"2026021807501089000_2025.09.10.675439v3.123","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04356-8"},{"key":"2026021807501089000_2025.09.10.675439v3.124","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"2026021807501089000_2025.09.10.675439v3.125","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.2742"},{"key":"2026021807501089000_2025.09.10.675439v3.126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06900.x"},{"key":"2026021807501089000_2025.09.10.675439v3.127","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-150543"},{"key":"2026021807501089000_2025.09.10.675439v3.128","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3203-x"},{"key":"2026021807501089000_2025.09.10.675439v3.129","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71062528.x"},{"key":"2026021807501089000_2025.09.10.675439v3.130","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160368"},{"key":"2026021807501089000_2025.09.10.675439v3.131","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104623"},{"key":"2026021807501089000_2025.09.10.675439v3.132","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac165"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.09.10.675439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:09:21Z","timestamp":1782277761000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.09.10.675439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":132,"URL":"https:\/\/doi.org\/10.1101\/2025.09.10.675439","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1021\/acschemneuro.5c00730","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2025,9,16]]},"subtype":"preprint"}}