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Many neurons modulate their firing rates at specific phases of theta (known as theta phase locking), creating discrete windows for information processing. Disrupted theta phase locking has been found across several neurological and psychiatric disorders (e.g., epilepsy), but gaps in technology have prevented its causal influence from being tested. Here, we developed PhaSER, a closed-loop optogenetic system designed to control the phase locking of specific interneurons, and demonstrate a causal role for inhibitory phase locking in seizure susceptibility. We first found that parvalbumin (PV+) and somatostatin (SOM+) expressing interneurons in the dentate gyrus (DG) show distinct theta phase locking profiles and are differentially impacted in a mouse model of chronic temporal lobe epilepsy. In healthy mice, PV+ interneurons have extremely consistent phase-locked firing near the trough of CA1 theta, aligned with excitatory inputs to DG. However, in epileptic mice, PV+ interneuron activity is dispersed across the theta cycle, suggesting that altered inhibitory phase locking could be a causal mediator of seizure susceptibility in epilepsy. To test this hypothesis, we applied PhaSER to directly control the phase locking of DG interneurons during an acute test of seizure susceptibility. In epileptic mice, re-aligning DG PV+ interneuron theta phase locking reduced seizure susceptibility, while in healthy mice, disrupting normal phase locking of PV+ interneurons increased seizure susceptibility. Together, this provides the first causal evidence that inhibitory theta phase locking can directly control network function by shifting seizure susceptibility in the healthy and epileptic brain.<\/jats:p>","DOI":"10.1101\/2025.09.10.675457","type":"posted-content","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T08:50:15Z","timestamp":1757580615000},"source":"Crossref","is-referenced-by-count":2,"title":["Interneuron theta phase locking controls seizure susceptibility"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-0140","authenticated-orcid":false,"given":"Zo\u00e9 Christenson","family":"Wick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-0342","authenticated-orcid":false,"given":"Paul A","family":"Philipsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-6312","authenticated-orcid":false,"given":"Cassidy","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3087-2659","authenticated-orcid":false,"given":"Sophia I","family":"Lamsifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Katanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-5301","authenticated-orcid":false,"given":"Christopher D","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-3746","authenticated-orcid":false,"given":"Yu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-7975","authenticated-orcid":false,"given":"Lauren M","family":"Vetere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1489-8118","authenticated-orcid":false,"given":"Genevra C","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corin","family":"Humphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-0523","authenticated-orcid":false,"given":"Denise J","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-6142","authenticated-orcid":false,"given":"Tristan","family":"Shuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025091501150667000_2025.09.10.675457v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90037-1"},{"key":"2025091501150667000_2025.09.10.675457v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.04.006"},{"key":"2025091501150667000_2025.09.10.675457v1.3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03061"},{"key":"2025091501150667000_2025.09.10.675457v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.014"},{"key":"2025091501150667000_2025.09.10.675457v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.09.011"},{"key":"2025091501150667000_2025.09.10.675457v1.6","doi-asserted-by":"crossref","unstructured":"Ku, S.-P. et al. 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