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Using a pH-responsive amyloid \u03b2 (A\u03b2\n                  <jats:sup>pH<\/jats:sup>\n                  ), we showed that microglial phagocytosis was reduced at 7 days post-impact on the chip. Simultaneously, neurons increased their uptake of A\u03b2, and decreased neuronal firing frequency at 7 days post-impact based on electrophysiological recordings. Given the importance of lipid metabolism in brain trauma and neurodegeneration, the lipidome secreted by impacted cells was analyzed to understand changes in cellular processes. 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