{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:35:38Z","timestamp":1785429338669,"version":"3.56.0"},"posted":{"date-parts":[[2025,9,17]]},"reference-count":87,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R01 AR079418"],"award-info":[{"award-number":["R01 AR079418"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["F31 AR083249"],"award-info":[{"award-number":["F31 AR083249"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P30 CA046592"],"award-info":[{"award-number":["P30 CA046592"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  The palmoplantar epidermis, in adapting to the exceptional mechanical strain it bears during locomotion, is molecularly and histologically distinct from other skin body sites. The mechanisms specifying and maintaining its unique identity remain incompletely defined. Here, we identify the type 1 keratin 9 (\n                  <jats:italic>KRT9<\/jats:italic>\n                  \/K9), a protein uniquely expressed in the palmoplantar epidermis, as a key modulator of mechanosensitive YAP1 signaling in response to postnatal mechanical compression. K9 loss-of-function variants, as observed in human\n                  <jats:italic>KRT9<\/jats:italic>\n                  palmoplantar epidermal differentiation disorder (\n                  <jats:italic>KRT9<\/jats:italic>\n                  -pEDD), result in aberrant YAP1 subcellular partitioning and elevated levels of the stress-induced keratin 16 (\n                  <jats:italic>KRT16<\/jats:italic>\n                  \/K16).\n                  <jats:italic>Krt9<\/jats:italic>\n                  null mice recapitulate these molecular phenotypes as early as postnatal day 3 (P3). We further identify dynamic, YAP1-dependent regulation of\n                  <jats:italic>Krt16<\/jats:italic>\n                  \/K16, upstream of\n                  <jats:italic>Krt9<\/jats:italic>\n                  \/K9 expression, during early postnatal development\n                  <jats:italic>in situ<\/jats:italic>\n                  and in response to mechanical compression of keratinocytes\n                  <jats:italic>ex vivo<\/jats:italic>\n                  , highlighting the role of mechanical stress in epidermal specification. Mechanistically, K9 interacts with the YAP1 binding protein 14-3-3\u03c3 and sequesters YAP1 in the cytoplasm, inhibiting its transcriptional activity; these functions are disrupted by\n                  <jats:italic>KRT9<\/jats:italic>\n                  -pEDD-causing variants in K9. Finally, we demonstrate that genetic or pharmacological inhibition of YAP1 ameliorates palmoplantar keratoderma in\n                  <jats:italic>Krt9<\/jats:italic>\n                  null mice. These findings reveal a role for mechanical cues in specification and maintenance of palmoplantar skin and suggest new therapeutic interventions for inherited palmoplantar epidermal differentiation disorders (pEDDs).\n                <\/jats:p>","DOI":"10.1101\/2025.09.15.676359","type":"posted-content","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T22:10:18Z","timestamp":1758147018000},"source":"Crossref","is-referenced-by-count":2,"title":["Under pressure: Keratin 9 regulates mechanosensitive YAP1 signaling in palmoplantar epidermis"],"prefix":"10.64898","author":[{"given":"Sarah N.","family":"Steiner","sequence":"first","affiliation":[{"name":"Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Horst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, 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