{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:48:28Z","timestamp":1793735308903,"version":"4.6.1"},"posted":{"date-parts":[[2025,9,19]]},"group-title":"Genetic and Genomic Medicine","reference-count":166,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,9,19]]},"abstract":"<jats:p>\n                  Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk loci for fibromyalgia. The strongest association was with a coding variant in\n                  <jats:italic>HTT<\/jats:italic>\n                  , the causal gene for Huntington\u2019s disease. Gene prioritization implicated the\n                  <jats:italic>HTT<\/jats:italic>\n                  regulator\n                  <jats:italic>GPR52<\/jats:italic>\n                  , as well as diverse genes with neural roles, including\n                  <jats:italic>CAMKV<\/jats:italic>\n                  ,\n                  <jats:italic>DCC<\/jats:italic>\n                  ,\n                  <jats:italic>DRD2<\/jats:italic>\n                  \/\n                  <jats:italic>NCAM1<\/jats:italic>\n                  ,\n                  <jats:italic>MDGA2<\/jats:italic>\n                  , and\n                  <jats:italic>CELF4<\/jats:italic>\n                  . Fibromyalgia heritability was exclusively enriched within brain tissues and neural cell types. Fibromyalgia showed strong, positive genetic correlation with a wide range of chronic pain, psychiatric, and somatic disorders, including genetic correlations above 0.7 with low back pain, post-traumatic stress disorder and irritable bowel syndrome. Despite large sex differences in fibromyalgia prevalence, the genetic architecture of fibromyalgia was nearly identical between males and females. This work provides the first robust genetic evidence defining fibromyalgia as a central nervous system disorder, thereby establishing a biological framework for its complex pathophysiology and extensive clinical comorbidities.\n                <\/jats:p>","DOI":"10.1101\/2025.09.18.25335914","type":"posted-content","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T15:25:15Z","timestamp":1758295515000},"source":"Crossref","is-referenced-by-count":3,"title":["The genetic architecture of fibromyalgia across 2.5 million individuals"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-250X","authenticated-orcid":false,"given":"Isabel","family":"Kerrebijn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-0306","authenticated-orcid":false,"given":"Gyda","family":"Bjornsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-8835","authenticated-orcid":false,"given":"Keon","family":"Arbabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-3518","authenticated-orcid":false,"given":"Lea","family":"Urpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hele","family":"Haapaniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudmar","family":"Thorleifsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilja","family":"Stefansdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Frangakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Valliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-6696","authenticated-orcid":false,"given":"Lovemore","family":"Kunorozva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-3161","authenticated-orcid":false,"given":"Erik","family":"Abner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7459-7646","authenticated-orcid":false,"given":"Caleb","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-1332","authenticated-orcid":false,"given":"Bitten","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bliddal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-5866","authenticated-orcid":false,"given":"S\u00f8ren","family":"Brunak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie T","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-496X","authenticated-orcid":false,"given":"Maria","family":"Didriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-6647","authenticated-orcid":false,"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arni J","family":"Geirsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"Gudbjartsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7762","authenticated-orcid":false,"given":"Thomas F","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingileif","family":"Jonsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk U","family":"Knowlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-6197","authenticated-orcid":false,"given":"Christina","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln D","family":"Nadauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorunn A","family":"Olafsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-3851","authenticated-orcid":false,"given":"Sisse R","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-5976","authenticated-orcid":false,"given":"Ole BV","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saedis","family":"Saevarsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-0933","authenticated-orcid":false,"given":"Astros T","family":"Skuladottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-9077","authenticated-orcid":false,"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hreinn","family":"Stefansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sulem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olafur A","family":"Sveinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudny E","family":"Thorlacius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unnur","family":"Thorsteinsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-9058","authenticated-orcid":false,"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnor","family":"Vikingsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Werge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Chronic Pain Genomics Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FinnGen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DBDS Genomic Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Estonian Biobank Research Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Genes & Health Research Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Stefansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-7242","authenticated-orcid":false,"given":"Chad M","family":"Brummett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-8482","authenticated-orcid":false,"given":"Bente","family":"Glintborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Clauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorgeir E","family":"Thorgeirsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-2744","authenticated-orcid":false,"given":"Frances MK","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-0601","authenticated-orcid":false,"given":"Nasa","family":"Sinnott-Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna M","family":"Ollila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wainberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025092204400839000_2025.09.18.25335914v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.76"},{"key":"2025092204400839000_2025.09.18.25335914v1.2","doi-asserted-by":"publisher","DOI":"10.7326\/aitc202003030"},{"key":"2025092204400839000_2025.09.18.25335914v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00506-w"},{"key":"2025092204400839000_2025.09.18.25335914v1.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"2025092204400839000_2025.09.18.25335914v1.5","first-page":"565","article-title":"The Comparative Burden of Chronic Widespread Pain and Fibromyalgia in the United States","volume":"16","year":"2016","journal-title":"Pain Pract. Off. J. World Inst. Pain"},{"key":"2025092204400839000_2025.09.18.25335914v1.6","doi-asserted-by":"crossref","unstructured":"Lacasse, A. , Bourgault, P. & Choini\u00e8re, M . Fibromyalgia-related costs and loss of productivity: a substantial societal burden. BMC Musculoskelet. Disord. 17, 168 (2016).","DOI":"10.1186\/s12891-016-1027-6"},{"key":"2025092204400839000_2025.09.18.25335914v1.7","first-page":"124","article-title":"The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes","volume":"12","year":"2006","journal-title":"J. Clin. Rheumatol. Pract. Rep. Rheum. Musculoskelet. Dis."},{"key":"2025092204400839000_2025.09.18.25335914v1.8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.semarthrit.2021.02.007","article-title":"Fibromyalgia and obesity: A comprehensive systematic review and meta-analysis","volume":"51","year":"2021","journal-title":"Semin. Arthritis Rheum"},{"key":"2025092204400839000_2025.09.18.25335914v1.9","doi-asserted-by":"crossref","unstructured":"Clauw, D. , Sarzi-Puttini, P. , Pellegrino, G. & Shoenfeld, Y . Is fibromyalgia an autoimmune disorder? Autoimmun. Rev. 23, 103424 (2024).","DOI":"10.1016\/j.autrev.2023.103424"},{"key":"2025092204400839000_2025.09.18.25335914v1.10","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: towards an understanding of prevalent pain conditions","volume":"397","year":"2021","journal-title":"The Lancet"},{"key":"2025092204400839000_2025.09.18.25335914v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/306686a0"},{"key":"2025092204400839000_2025.09.18.25335914v1.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.06.012"},{"key":"2025092204400839000_2025.09.18.25335914v1.13","doi-asserted-by":"publisher","DOI":"10.1111\/jabr.12137"},{"key":"2025092204400839000_2025.09.18.25335914v1.14","doi-asserted-by":"crossref","unstructured":"Lee, Y. C. , Nassikas, N. J. & Clauw, D. J . The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res. Ther. 13, 211 (2011).","DOI":"10.1186\/ar3306"},{"key":"2025092204400839000_2025.09.18.25335914v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00032-1"},{"key":"2025092204400839000_2025.09.18.25335914v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.022"},{"key":"2025092204400839000_2025.09.18.25335914v1.17","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"2025092204400839000_2025.09.18.25335914v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.09.018"},{"key":"2025092204400839000_2025.09.18.25335914v1.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.01.001"},{"key":"2025092204400839000_2025.09.18.25335914v1.20","doi-asserted-by":"publisher","DOI":"10.2174\/1573397112666151231111104"},{"key":"2025092204400839000_2025.09.18.25335914v1.21","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460334.49525.5e"},{"key":"2025092204400839000_2025.09.18.25335914v1.22","doi-asserted-by":"publisher","DOI":"10.1097\/J.PAIN.0000000000000615"},{"key":"2025092204400839000_2025.09.18.25335914v1.23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem345"},{"key":"2025092204400839000_2025.09.18.25335914v1.24","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000285"},{"key":"2025092204400839000_2025.09.18.25335914v1.25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2217\/pmt-2018-0024","article-title":"Fibromyalgia: is it a neuropathic pain?","volume":"8","year":"2018","journal-title":"Pain Manag"},{"key":"2025092204400839000_2025.09.18.25335914v1.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05344.x"},{"key":"2025092204400839000_2025.09.18.25335914v1.27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000514756","article-title":"Neuroendocrine Modulation of Cognitive Performance in the Patients with Fibromyalgia","volume":"84","year":"2021","journal-title":"Eur. Neurol"},{"key":"2025092204400839000_2025.09.18.25335914v1.28","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0427-8"},{"key":"2025092204400839000_2025.09.18.25335914v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.01.010"},{"key":"2025092204400839000_2025.09.18.25335914v1.30","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.3390\/jcm9113527","article-title":"Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance","volume":"9","year":"2020","journal-title":"J. Clin. Med"},{"key":"2025092204400839000_2025.09.18.25335914v1.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"2025092204400839000_2025.09.18.25335914v1.32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3390\/jcm9041219","article-title":"Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives","volume":"9","year":"2020","journal-title":"J. Clin. Med"},{"key":"2025092204400839000_2025.09.18.25335914v1.33","doi-asserted-by":"publisher","DOI":"10.31486\/toj.21.0038"},{"key":"2025092204400839000_2025.09.18.25335914v1.34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/pmt-2016-0007","article-title":"Fibromyalgia Syndrome: Novel Therapeutic Targets","volume":"6","year":"2016","journal-title":"Pain Manag"},{"key":"2025092204400839000_2025.09.18.25335914v1.35","doi-asserted-by":"publisher","DOI":"10.1002\/art.20042"},{"key":"2025092204400839000_2025.09.18.25335914v1.36","doi-asserted-by":"publisher","DOI":"10.1002\/art.37842"},{"key":"2025092204400839000_2025.09.18.25335914v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.02.016"},{"key":"2025092204400839000_2025.09.18.25335914v1.38","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/art.41171","article-title":"Heritability of the Fibromyalgia Phenotype Varies by Age","volume":"72","year":"2020","journal-title":"Arthritis Rheumatol. Hoboken NJ"},{"key":"2025092204400839000_2025.09.18.25335914v1.39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"2025092204400839000_2025.09.18.25335914v1.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008164"},{"key":"2025092204400839000_2025.09.18.25335914v1.41","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201742"},{"key":"2025092204400839000_2025.09.18.25335914v1.42","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.3500"},{"key":"2025092204400839000_2025.09.18.25335914v1.43","doi-asserted-by":"crossref","first-page":"e1010977","DOI":"10.1371\/journal.pgen.1010977","article-title":"Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits","volume":"19","year":"2023","journal-title":"PLoS Genet"},{"key":"2025092204400839000_2025.09.18.25335914v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02839-5"},{"key":"2025092204400839000_2025.09.18.25335914v1.45","doi-asserted-by":"crossref","unstructured":"Cooksey, R. & Choy, E . Exploring gender differences, medical history, and treatments used in patients with fibromyalgia in the UK using primary-care data: a retrospective, population-based, cohort study. Lancet Rheumatol. 4, S20 (2022).","DOI":"10.1016\/S2665-9913(22)00296-X"},{"key":"2025092204400839000_2025.09.18.25335914v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0310-6"},{"key":"2025092204400839000_2025.09.18.25335914v1.47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41588-025-02084-7","article-title":"Prioritizing effector genes at trait-associated loci using multimodal evidence","volume":"57","year":"2025","journal-title":"Nat. Genet"},{"key":"2025092204400839000_2025.09.18.25335914v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"2025092204400839000_2025.09.18.25335914v1.49","doi-asserted-by":"crossref","unstructured":"Fields, E. et al. Gene Targeting Techniques for Huntington\u2019s Disease. Ageing Res. Rev. 70, 101385 (2021).","DOI":"10.1016\/j.arr.2021.101385"},{"key":"2025092204400839000_2025.09.18.25335914v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2020.04.001"},{"key":"2025092204400839000_2025.09.18.25335914v1.51","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3338"},{"key":"2025092204400839000_2025.09.18.25335914v1.52","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318249f683"},{"key":"2025092204400839000_2025.09.18.25335914v1.53","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/mt.2015.128","article-title":"Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry","volume":"23","year":"2015","journal-title":"Mol. Ther"},{"key":"2025092204400839000_2025.09.18.25335914v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3267"},{"key":"2025092204400839000_2025.09.18.25335914v1.55","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02227-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2019-0"},{"key":"2025092204400839000_2025.09.18.25335914v1.57","doi-asserted-by":"crossref","unstructured":"Yao, Y. et al. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. eLife 4, e05449.","DOI":"10.7554\/eLife.05449"},{"key":"2025092204400839000_2025.09.18.25335914v1.58","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy081"},{"key":"2025092204400839000_2025.09.18.25335914v1.59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01133"},{"key":"2025092204400839000_2025.09.18.25335914v1.60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003067"},{"key":"2025092204400839000_2025.09.18.25335914v1.61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41730-8"},{"key":"2025092204400839000_2025.09.18.25335914v1.62","doi-asserted-by":"crossref","unstructured":"Mueth, M. G. et al. The RNA-binding protein CELF4 is a negative regulator of sensory neuron excitability and mechanical and heat behavioral sensitivity. Neurobiol . Pain 18, 100184 (2025).","DOI":"10.1016\/j.ynpai.2025.100184"},{"key":"2025092204400839000_2025.09.18.25335914v1.63","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9793-z"},{"key":"2025092204400839000_2025.09.18.25335914v1.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.08.050"},{"key":"2025092204400839000_2025.09.18.25335914v1.65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324756"},{"key":"2025092204400839000_2025.09.18.25335914v1.66","doi-asserted-by":"crossref","unstructured":"Zamboni, V. et al. Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits. Sci. Rep. 6, 34877 (2016).","DOI":"10.1038\/srep34877"},{"key":"2025092204400839000_2025.09.18.25335914v1.67","doi-asserted-by":"crossref","unstructured":"Liaci, C. et al. Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy. Front. Cell Dev. Biol. 10, 875468 (2022).","DOI":"10.3389\/fcell.2022.875468"},{"key":"2025092204400839000_2025.09.18.25335914v1.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25354-3"},{"key":"2025092204400839000_2025.09.18.25335914v1.69","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1432-1033.1996.0460u.x","article-title":"Isolation and expression of a cDNA clone encoding human kynureninase","volume":"239","year":"1996","journal-title":"Eur. J. Biochem"},{"key":"2025092204400839000_2025.09.18.25335914v1.70","doi-asserted-by":"crossref","unstructured":"Hazrati, E. , Eftekhar, S. P. , Mosaed, R. , Shiralizadeh Dini, S. & Namazi, M . Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions. Mol. Pain 20, 17448069241275097 (2024).","DOI":"10.1177\/17448069241275097"},{"key":"2025092204400839000_2025.09.18.25335914v1.71","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jpain.2017.03.014","article-title":"Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents","volume":"18","year":"2017","journal-title":"J. Pain"},{"key":"2025092204400839000_2025.09.18.25335914v1.72","doi-asserted-by":"crossref","unstructured":"Arnau-Soler, A. et al. Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Transl. Psychiatry 9, 14 (2019).","DOI":"10.1038\/s41398-018-0360-y"},{"key":"2025092204400839000_2025.09.18.25335914v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.025"},{"key":"2025092204400839000_2025.09.18.25335914v1.74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08917-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.75","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv434"},{"key":"2025092204400839000_2025.09.18.25335914v1.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.07.015"},{"key":"2025092204400839000_2025.09.18.25335914v1.77","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/cam.3.1.6773","article-title":"Cell adhesion molecules in the central nervous system","volume":"3","year":"2009","journal-title":"Cell Adhes. Migr"},{"key":"2025092204400839000_2025.09.18.25335914v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00093-5"},{"key":"2025092204400839000_2025.09.18.25335914v1.79","doi-asserted-by":"crossref","unstructured":"Vukojevic, V. et al. Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Transl. Psychiatry 10, 217 (2020).","DOI":"10.1038\/s41398-020-00899-y"},{"key":"2025092204400839000_2025.09.18.25335914v1.80","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.81","doi-asserted-by":"crossref","unstructured":"Barylko, B. et al. Palmitoylation-regulated interactions of the pseudokinase calmodulin kinase-like vesicle-associated with membranes and Arc\/Arg3.1. Front. Synaptic Neurosci. 14, 926570 (2022).","DOI":"10.3389\/fnsyn.2022.926570"},{"key":"2025092204400839000_2025.09.18.25335914v1.82","doi-asserted-by":"crossref","unstructured":"Liang, Z. et al. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat. Commun. 7, 13282 (2016).","DOI":"10.1038\/ncomms13282"},{"key":"2025092204400839000_2025.09.18.25335914v1.83","first-page":"3593","article-title":"Notch signaling: simplicity in design, versatility in function","volume":"138","year":"2011","journal-title":"Dev. Camb. Engl"},{"key":"2025092204400839000_2025.09.18.25335914v1.84","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1847"},{"key":"2025092204400839000_2025.09.18.25335914v1.85","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3024"},{"key":"2025092204400839000_2025.09.18.25335914v1.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.01.002"},{"key":"2025092204400839000_2025.09.18.25335914v1.87","doi-asserted-by":"crossref","unstructured":"Joset, P. et al. Rostral growth of commissural axons requires the cell adhesion molecule MDGA2. Neural Develop. 6, 22 (2011).","DOI":"10.1186\/1749-8104-6-22"},{"key":"2025092204400839000_2025.09.18.25335914v1.88","doi-asserted-by":"crossref","first-page":"e3003047","DOI":"10.1371\/journal.pbio.3003047","article-title":"Mdga2 deficiency leads to an aberrant activation of BDNF\/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice","volume":"23","year":"2025","journal-title":"PLOS Biol"},{"key":"2025092204400839000_2025.09.18.25335914v1.89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000536"},{"key":"2025092204400839000_2025.09.18.25335914v1.90","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81336-7"},{"key":"2025092204400839000_2025.09.18.25335914v1.91","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0448-14.2014"},{"key":"2025092204400839000_2025.09.18.25335914v1.92","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115954"},{"key":"2025092204400839000_2025.09.18.25335914v1.93","doi-asserted-by":"crossref","first-page":"e1263","DOI":"10.1097\/PR9.0000000000001263","article-title":"The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis","volume":"10","year":"2025","journal-title":"Pain Rep"},{"key":"2025092204400839000_2025.09.18.25335914v1.94","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12908"},{"key":"2025092204400839000_2025.09.18.25335914v1.95","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/AJP.0000000000000153","article-title":"Natural variation in testosterone is associated with hypoalgesia in healthy women","volume":"31","year":"2015","journal-title":"Clin. J. Pain"},{"key":"2025092204400839000_2025.09.18.25335914v1.96","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/stem.1569","article-title":"Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia","volume":"32","year":"2014","journal-title":"Stem Cells Dayt. Ohio"},{"key":"2025092204400839000_2025.09.18.25335914v1.97","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv178"},{"key":"2025092204400839000_2025.09.18.25335914v1.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.030"},{"key":"2025092204400839000_2025.09.18.25335914v1.99","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41431-024-01701-z","article-title":"BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations","volume":"33","year":"2025","journal-title":"Eur. J. Hum. Genet"},{"key":"2025092204400839000_2025.09.18.25335914v1.100","doi-asserted-by":"publisher","DOI":"10.1038\/nature13772"},{"key":"2025092204400839000_2025.09.18.25335914v1.101","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051810-093157"},{"key":"2025092204400839000_2025.09.18.25335914v1.102","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/ajmg.a.62102","article-title":"Phenotypic expansion of the BPTF-related neurodevelopmental disorder with dysmorphic facies and distal limb anomalies","volume":"185","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"key":"2025092204400839000_2025.09.18.25335914v1.103","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1182\/blood-2024-210853","article-title":"An Anti-Apoptotic Protein C17ORF58 Is Critical for the Maintenance of Human Peripheral T-Cell Lymphomas By Suppressing BBC3-Induced Apoptosis","volume":"144","year":"2024","journal-title":"Blood"},{"key":"2025092204400839000_2025.09.18.25335914v1.104","first-page":"193","article-title":"De novo missense variants in the PP2A regulatory subunit PPP2R2B in a neurodevelopmental syndrome: potential links to mitochondrial dynamics and spinocerebellar ataxias","volume":"34","year":"2024","journal-title":"Hum. Mol. Genet"},{"key":"2025092204400839000_2025.09.18.25335914v1.105","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.02.036"},{"key":"2025092204400839000_2025.09.18.25335914v1.106","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-51892-7.00034-6"},{"key":"2025092204400839000_2025.09.18.25335914v1.107","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab245"},{"key":"2025092204400839000_2025.09.18.25335914v1.108","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1097\/j.pain.0000000000002156","article-title":"G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of G\u03b2\u03b3\/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion","volume":"162","year":"2021","journal-title":"Pain"},{"key":"2025092204400839000_2025.09.18.25335914v1.109","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-14265-0_8"},{"key":"2025092204400839000_2025.09.18.25335914v1.110","doi-asserted-by":"crossref","unstructured":"Dardis, A. et al. Altered localization and functionality of TAR DNA Binding Protein 43 (TDP-43) in niemann-pick disease type C. Acta Neuropathol. Commun. 4, 52 (2016).","DOI":"10.1186\/s40478-016-0325-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.111","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0960-9822(01)00396-7","article-title":"Critical role for glycosphingolipids in Niemann-Pick disease type C","volume":"11","year":"2001","journal-title":"Curr. Biol. CB"},{"key":"2025092204400839000_2025.09.18.25335914v1.112","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00392-17"},{"key":"2025092204400839000_2025.09.18.25335914v1.113","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0081-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.114","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1164\/rccm.201611-2232PP","article-title":"Eosinophilic and Noneosinophilic Asthma","volume":"197","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025092204400839000_2025.09.18.25335914v1.115","doi-asserted-by":"crossref","unstructured":"Olafsdottir, T. A. et al. Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis. Nat. Commun. 11, 393 (2020).","DOI":"10.1038\/s41467-019-14144-8"},{"key":"2025092204400839000_2025.09.18.25335914v1.116","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jaci.2024.10.002","article-title":"A partial loss-of-function variant in STAT6 protects against type 2 asthma","volume":"155","year":"2025","journal-title":"J. Allergy Clin. Immunol"},{"key":"2025092204400839000_2025.09.18.25335914v1.117","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000752"},{"key":"2025092204400839000_2025.09.18.25335914v1.118","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/art.39851","article-title":"Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association Between Seronegative Disease and Fibromyalgia","volume":"69","year":"2017","journal-title":"Arthritis Rheumatol. Hoboken NJ"},{"key":"2025092204400839000_2025.09.18.25335914v1.119","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/annrheumdis-2021-221754","article-title":"Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset","volume":"81","year":"2022","journal-title":"Ann. Rheum. Dis"},{"key":"2025092204400839000_2025.09.18.25335914v1.120","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.07.24315052"},{"key":"2025092204400839000_2025.09.18.25335914v1.121","unstructured":"Collaboration, D. Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis\/chronic fatigue syndrome. (2025)."},{"key":"2025092204400839000_2025.09.18.25335914v1.122","first-page":"S104","article-title":"Misdiagnosis in fibromyalgia: a multicentre study","volume":"29","year":"2011","journal-title":"Clin. Exp. Rheumatol"},{"key":"2025092204400839000_2025.09.18.25335914v1.123","first-page":"S9","article-title":"Prevalence and clinical impact of fibromyalgia in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"34","year":"2016","journal-title":"Clin. Exp. Rheumatol"},{"key":"2025092204400839000_2025.09.18.25335914v1.124","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/acr2.11229","article-title":"Validation of Self-Reported Rheumatoid Arthritis Using Medicare Claims: A Nationally Representative Longitudinal Study of Older Adults","volume":"3","year":"2021","journal-title":"ACR Open Rheumatol"},{"key":"2025092204400839000_2025.09.18.25335914v1.125","doi-asserted-by":"crossref","unstructured":"Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. GigaScience 4, s13742-015-0047\u20138 (2015).","DOI":"10.1186\/s13742-015-0047-8"},{"key":"2025092204400839000_2025.09.18.25335914v1.126","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-021-00870-7"},{"key":"2025092204400839000_2025.09.18.25335914v1.127","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3643"},{"key":"2025092204400839000_2025.09.18.25335914v1.128","doi-asserted-by":"publisher","DOI":"10.1038\/nature14962"},{"key":"2025092204400839000_2025.09.18.25335914v1.129","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2025092204400839000_2025.09.18.25335914v1.130","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-02205473-8"},{"key":"2025092204400839000_2025.09.18.25335914v1.131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003981"},{"key":"2025092204400839000_2025.09.18.25335914v1.132","doi-asserted-by":"crossref","unstructured":"Dashti, H. S. et al. Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank. BMC Med. 20, 5 (2022).","DOI":"10.1186\/s12916-021-02198-9"},{"key":"2025092204400839000_2025.09.18.25335914v1.133","doi-asserted-by":"crossref","unstructured":"Zawistowski, M. et al. The Michigan Genomics Initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patients. Cell Genomics 3, 100257 (2023).","DOI":"10.1016\/j.xgen.2023.100257"},{"key":"2025092204400839000_2025.09.18.25335914v1.134","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3247"},{"key":"2025092204400839000_2025.09.18.25335914v1.135","doi-asserted-by":"crossref","unstructured":"J\u00f3nsson, H. et al. Whole genome characterization of sequence diversity of 15,220 Icelanders. Sci. Data 4, 170115 (2017).","DOI":"10.1038\/sdata.2017.115"},{"key":"2025092204400839000_2025.09.18.25335914v1.136","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3964"},{"key":"2025092204400839000_2025.09.18.25335914v1.137","doi-asserted-by":"publisher","DOI":"10.1038\/ng.216"},{"key":"2025092204400839000_2025.09.18.25335914v1.138","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.ejhg.5200530","article-title":"Protection of privacy by third-party encryption in genetic research in Iceland","volume":"8","year":"2000","journal-title":"Eur. J. Hum. Genet. EJHG"},{"key":"2025092204400839000_2025.09.18.25335914v1.139","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa157"},{"key":"2025092204400839000_2025.09.18.25335914v1.140","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028401"},{"key":"2025092204400839000_2025.09.18.25335914v1.141","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13225-y"},{"key":"2025092204400839000_2025.09.18.25335914v1.142","doi-asserted-by":"crossref","unstructured":"Banasik, K. et al. DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals. BMC Genomic Data 24, 30 (2023).","DOI":"10.1186\/s12863-023-01132-7"},{"key":"2025092204400839000_2025.09.18.25335914v1.143","doi-asserted-by":"crossref","unstructured":"Azriel, E. et al. Utilizing Public Health Frameworks and Partnerships to Ensure Equity in DNA-Based Population Screening. Front. Genet. 13, 886755 (2022).","DOI":"10.3389\/fgene.2022.886755"},{"key":"2025092204400839000_2025.09.18.25335914v1.144","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"2025092204400839000_2025.09.18.25335914v1.145","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"2025092204400839000_2025.09.18.25335914v1.146","doi-asserted-by":"publisher","DOI":"10.1101\/gr.277525.122"},{"key":"2025092204400839000_2025.09.18.25335914v1.147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000505"},{"key":"2025092204400839000_2025.09.18.25335914v1.148","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3710"},{"key":"2025092204400839000_2025.09.18.25335914v1.149","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"2025092204400839000_2025.09.18.25335914v1.150","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3404"},{"key":"2025092204400839000_2025.09.18.25335914v1.151","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopsych.2022.05.029","article-title":"Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution","volume":"93","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"2025092204400839000_2025.09.18.25335914v1.152","doi-asserted-by":"publisher","DOI":"10.1038\/nature09298"},{"key":"2025092204400839000_2025.09.18.25335914v1.153","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky837"},{"key":"2025092204400839000_2025.09.18.25335914v1.154","doi-asserted-by":"publisher","DOI":"10.1111\/rssb.12388"},{"key":"2025092204400839000_2025.09.18.25335914v1.155","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01443-6"},{"key":"2025092204400839000_2025.09.18.25335914v1.156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"2025092204400839000_2025.09.18.25335914v1.157","doi-asserted-by":"crossref","unstructured":"McLaren, W. et al. The Ensembl Variant Effect Predictor. Genome Biol. 17, 122 (2016).","DOI":"10.1186\/s13059-016-0974-4"},{"key":"2025092204400839000_2025.09.18.25335914v1.158","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"2025092204400839000_2025.09.18.25335914v1.159","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00978-w"},{"key":"2025092204400839000_2025.09.18.25335914v1.160","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"2025092204400839000_2025.09.18.25335914v1.161","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.457"},{"key":"2025092204400839000_2025.09.18.25335914v1.162","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06563-x"},{"key":"2025092204400839000_2025.09.18.25335914v1.163","first-page":"eadn3949","article-title":"A panoramic view of cell population dynamics in mammalian aging","volume":"387","year":"2024","journal-title":"Science"},{"key":"2025092204400839000_2025.09.18.25335914v1.164","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"2025092204400839000_2025.09.18.25335914v1.165","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"2025092204400839000_2025.09.18.25335914v1.166","doi-asserted-by":"crossref","unstructured":"Priv\u00e9, F. , Arbel, J. , Aschard, H. & Vilhj\u00e1lmsson, B. J . Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores. Hum. Genet. Genomics Adv. 3, (2022).","DOI":"10.1016\/j.xhgg.2022.100136"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.09.18.25335914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:46:19Z","timestamp":1768509979000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.09.18.25335914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":166,"URL":"https:\/\/doi.org\/10.1101\/2025.09.18.25335914","relation":{},"subject":[],"published":{"date-parts":[[2025,9,19]]},"subtype":"preprint"}}