{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:27:47Z","timestamp":1768570067396,"version":"3.49.0"},"posted":{"date-parts":[[2025,9,29]]},"group-title":"Neurology","reference-count":19,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  The genome-wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329\n                  <jats:sup>A<\/jats:sup>\n                  to long-term disability, suggesting it affects central nervous system resilience. We hypothesised that rs10191329\n                  <jats:sup>A<\/jats:sup>\n                  might influence cognition in other neurological diseases and in healthy controls. We explored the relationship between rs10191329\n                  <jats:sup>A<\/jats:sup>\n                  and cognitive function - measured using reaction time, fluid intelligence, and prospective memory tests - in the United Kingdom Biobank. Rs10191329\n                  <jats:sup>A<\/jats:sup>\n                  was consistently associated with poorer cognition in controls, with similar but non-significant trends in Multiple Sclerosis, Parkinson\u2019s disease, and dementia. Our results support the hypothesis that rs10191329\n                  <jats:sup>A<\/jats:sup>\n                  affects multiple sclerosis outcomes by modulating brain health.\n                <\/jats:p>","DOI":"10.1101\/2025.09.28.25336369","type":"posted-content","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T23:30:12Z","timestamp":1759188612000},"source":"Crossref","is-referenced-by-count":0,"title":["The Multiple Sclerosis severity allele rs10191329\n                  <sup>A<\/sup>\n                  and cognitive function: a UK Biobank study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2913-0672","authenticated-orcid":false,"given":"Ioanna","family":"Zimianiti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheena","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-7274","authenticated-orcid":false,"given":"Adil","family":"Harroud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernilla","family":"Stridh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Dobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-6010","authenticated-orcid":false,"given":"Benjamin M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025100111401094000_2025.09.28.25336369v1.1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jamaneurol.2020.1568","article-title":"Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials","volume":"77","year":"2020","journal-title":"JAMA Neurol"},{"key":"2025100111401094000_2025.09.28.25336369v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06250-x"},{"key":"2025100111401094000_2025.09.28.25336369v1.3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/ana.26807","article-title":"A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy","volume":"94","year":"2023","journal-title":"Ann Neurol"},{"key":"2025100111401094000_2025.09.28.25336369v1.4","first-page":"596","article-title":"Increased Disability Progression in rs10191329AA Carriers with Multiple Sclerosis Is Preceded by Neurofilament Light Chain Elevations","volume":"97","year":"2024","journal-title":"Ann Neurol"},{"key":"2025100111401094000_2025.09.28.25336369v1.5","doi-asserted-by":"crossref","unstructured":"Bsteh G , Tanavade R , Krajnc N , F\u00f6ttinger F , et al. The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis. 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Apocrita - High Performance Computing Cluster for Queen Mary University of London. Queen Mary Univ London, Tech Rep. 2017;1\u20132."},{"key":"2025100111401094000_2025.09.28.25336369v1.18","first-page":"79","article-title":"Incidence and prevalence of multiple sclerosis in the UK 1990-2010: A descriptive study in the General Practice Research Database","volume":"85","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025100111401094000_2025.09.28.25336369v1.19","doi-asserted-by":"crossref","first-page":"112430","DOI":"10.1016\/j.isci.2025.112430","article-title":"Multiple sclerosis severity variant in DYSF-ZNF638 locus associates with neuronal loss and inflammation","volume":"28","year":"2025","journal-title":"iScience"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.09.28.25336369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T20:47:12Z","timestamp":1768510032000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.09.28.25336369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1101\/2025.09.28.25336369","relation":{},"subject":[],"published":{"date-parts":[[2025,9,29]]},"subtype":"preprint"}}