{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:12:42Z","timestamp":1787670762336,"version":"build-2736575974"},"posted":{"date-parts":[[2025,10,1]]},"reference-count":80,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["DAVIS20XX2"],"award-info":[{"award-number":["DAVIS20XX2"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"award":["HUANG22G0"],"award-info":[{"award-number":["HUANG22G0"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"award":["HUANG24P0"],"award-info":[{"award-number":["HUANG24P0"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"award":["008697225"],"award-info":[{"award-number":["008697225"]}],"id":[{"id":"https:\/\/ror.org\/00ax59295","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}]},{"name":"NIH","award":["1S10OD024977-01"],"award-info":[{"award-number":["1S10OD024977-01"]}]},{"name":"NIH","award":["R01 HL159712"],"award-info":[{"award-number":["R01 HL159712"]}]},{"name":"NIH","award":["R01 CA246130"],"award-info":[{"award-number":["R01 CA246130"]}]},{"name":"NIH","award":["R01 HL153511-01"],"award-info":[{"award-number":["R01 HL153511-01"]}]},{"name":"NIH","award":["R01 HL139876"],"award-info":[{"award-number":["R01 HL139876"]}]},{"name":"DoD","award":["W81XWH2110081"],"award-info":[{"award-number":["W81XWH2110081"]}]},{"name":"DoD","award":["RCRP HT9425-24-1-0957"],"award-info":[{"award-number":["RCRP HT9425-24-1-0957"]}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas (CPRIT","doi-asserted-by":"crossref","award":["RP240610"],"award-info":[{"award-number":["RP240610"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chan Zuckerberg Initiative, an advised fund of the Silicon Valley Community","award":["2019-002440"],"award-info":[{"award-number":["2019-002440"]}]},{"name":"Chan Zuckerberg Initiative, an advised fund of the Silicon Valley Community","award":["2021-237566"],"award-info":[{"award-number":["2021-237566"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,6,29]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Basal cells (BCs) are the primary stem cell population of adult human airways and a key target for hPSC-based models of airway development, disease and regenerative medicine. Recent studies have revealed substantial regional differences between human proximal and distal airway cell types, including BCs. Here, we show that the NOGGIN-BMP signaling axis governs proximal-distal patterning of hPSC-derived lung progenitors leading to the generation of region-specific induced BCs (iBCs). Continuous BMP inhibition through NOGGIN, coupled with tapered WNT activation, generates proximal iBCs that molecularly and functionally resemble human proximal airway BCs and differentiate\n                  <jats:italic>in vitro<\/jats:italic>\n                  and\n                  <jats:italic>in vivo<\/jats:italic>\n                  into the full repertoire of specialized proximal airway cell types, including ionocytes and pulmonary neuroendocrine cells. In sharp contrast, BMP activation with tapered WNT generates distal airway-like cells and distal BCs with limited ionocyte differentiation potential. Progeny of proximal iBCs derived from G551D\n                  <jats:italic>CFTR<\/jats:italic>\n                  mutant hiPSCs also recapitulate a cystic fibrosis-associated ionocyte phenotype.\n                <\/jats:p>","DOI":"10.1101\/2025.10.01.657190","type":"posted-content","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:15:16Z","timestamp":1759382116000},"source":"Crossref","is-referenced-by-count":2,"title":["Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of NOGGIN-BMP Axis"],"prefix":"10.64898","author":[{"given":"Shingo","family":"Suzuki","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"},{"name":"Department of Medicine, The University of Alabama at Birmingham, School of Medicine, Birmingham, AL, 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole V.","family":"Acosta Sandoval","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"},{"name":"Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shnutez","family":"Doddipalli","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Barill\u00e0","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"},{"name":"Department of Medicine, The University of Alabama at Birmingham, School of Medicine, Birmingham, AL, 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Rab","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo-Fan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John M.","family":"Avila","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, 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