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INCLOSE analysis of CITE-seq data of acute myeloid leukemia and healthy samples uncovered cell populations exclusively found in the leukemia samples or the healthy samples. These condition-specific cell populations strongly suggested that immune suppression in tumor microenvironment plays a pivotal role in driving tumor progression.\n                <\/jats:p>","DOI":"10.1101\/2025.10.03.680413","type":"posted-content","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:55:33Z","timestamp":1760000133000},"source":"Crossref","is-referenced-by-count":0,"title":["Discovering Condition-specific Cell Populations via Integrative Clustering of Single-cell Data"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-0919","authenticated-orcid":false,"given":"Rekha","family":"Mudappathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-0187","authenticated-orcid":false,"given":"Bhardwaj","family":"Vaishali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4002-7497","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025102901523252000_2025.10.03.680413v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00528-0"},{"key":"2025102901523252000_2025.10.03.680413v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0088-9"},{"key":"2025102901523252000_2025.10.03.680413v1.3","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-022-02622-0"},{"key":"2025102901523252000_2025.10.03.680413v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4380"},{"key":"2025102901523252000_2025.10.03.680413v1.5","unstructured":"Knorr, K.H.S ; Rahman, J ; Abdel-Wahab O (NCBI GEO Database; 2022)."},{"key":"2025102901523252000_2025.10.03.680413v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELL.2021.04.048"},{"key":"2025102901523252000_2025.10.03.680413v1.7","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02116-x"},{"key":"2025102901523252000_2025.10.03.680413v1.8","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.1002\/cam4.3360","article-title":"Immunosuppressive role of CD11b(+) CD33(+) HLA-DR(-) myeloid-derived suppressor cells-like blast subpopulation in acute myeloid leukemia","volume":"9","year":"2020","journal-title":"Cancer Med"},{"key":"2025102901523252000_2025.10.03.680413v1.9","doi-asserted-by":"crossref","unstructured":"Dou, A. & Fang, J. 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