{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:46:01Z","timestamp":1788572761642,"version":"build-2803163510"},"posted":{"date-parts":[[2025,10,12]]},"group-title":"Immunology","reference-count":104,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"award":["R01HL142629"],"award-info":[{"award-number":["R01HL142629"]}],"id":[{"id":"https:\/\/ror.org\/012pb6c26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Efferocytosis, phagocytic clearance of apoptotic cells, is crucial for inflammation resolution and maintenance of tissue homeostasis. However, it is not known how epigenetic alterations govern macrophage-mediated efferocytosis. A Cleavage Under Targets and Release Using Nuclease (CUT&amp;RUN) sequencing revealed a genome-wide selective suppression of H3K9me3, a heterochromatin mark that represses gene activity, in macrophages undergoing efferocytosis. Moreover, Recombination Signal Binding Protein for Immunoglobulin Kappa J region (RBPJ), which is a transcription factor typically involved in the canonical Notch signaling process, dampened this epigenetic modification, enhanced apoptotic cell clearance, and suppressed inflammation by mouse atherosclerotic plaque, alveolar, peritoneal, and bone marrow-derived macrophages and human primary macrophages. Inhibition of the Notch signaling in macrophages significantly reduced efferocytosis whereas activation of this signaling augmented apoptotic debris clearance. Mechanistically, RBPJ upregulated\n                  <jats:italic>Stard13<\/jats:italic>\n                  and\n                  <jats:italic>Arsg<\/jats:italic>\n                  by diminishing H3K9me3 on their promoters.\n                  <jats:italic>Stard13<\/jats:italic>\n                  promoted efferocytosis by magnifying actin polymerization via inhibition and activation of Rho and RAC GTPases, respectively. Genetic and pharmacological inhibitions of SUV39H1\/H2, the methyltransferases that are responsible for H3K9 trimethylation, amplified the expression of\n                  <jats:italic>Stard13<\/jats:italic>\n                  and\n                  <jats:italic>Arsg<\/jats:italic>\n                  , and augmented efferocytosis by\n                  <jats:italic>RBPJ<\/jats:italic>\n                  <jats:sup>-\/-<\/jats:sup>\n                  macrophages. In sum, this study shows epigenetic regulation of efferocytosis in tissue macrophages.\n                <\/jats:p>","DOI":"10.1101\/2025.10.10.681723","type":"posted-content","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:05:12Z","timestamp":1760331912000},"source":"Crossref","is-referenced-by-count":9,"title":["Macrophage efferocytosis is controlled by epigenetic modifications mediated by RBPJ"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-0221","authenticated-orcid":false,"given":"Samreen","family":"Sadaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-5938","authenticated-orcid":false,"given":"Imran","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Modugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7456-1757","authenticated-orcid":false,"given":"Partha","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"issue":"7","key":"2025101515351191000_2025.10.10.681723v1.1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025101515351191000_2025.10.10.681723v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0240-6"},{"key":"2025101515351191000_2025.10.10.681723v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3253"},{"key":"2025101515351191000_2025.10.10.681723v1.4","doi-asserted-by":"crossref","unstructured":"Chen S , Chandra Tjin C , Gao X , Xue Y , Jiao H , Zhang R , et al. Pharmacological inhibition of PI5P4K\u03b1\/\u03b2 disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021;118(21).","DOI":"10.1073\/pnas.2002486118"},{"key":"2025101515351191000_2025.10.10.681723v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0673-x"},{"key":"2025101515351191000_2025.10.10.681723v1.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046462"},{"key":"2025101515351191000_2025.10.10.681723v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.001"},{"key":"2025101515351191000_2025.10.10.681723v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03994-2"},{"key":"2025101515351191000_2025.10.10.681723v1.9","doi-asserted-by":"crossref","unstructured":"Harro CM , Perez-Sanz J , Costich TL , Payne KK , Anadon CM , Chaurio RA , et al. Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice. J Clin Invest. 2021;131(3).","DOI":"10.1172\/JCI135711"},{"issue":"1","key":"2025101515351191000_2025.10.10.681723v1.10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41423-018-0170-4","article-title":"Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-\u03b2 production by mediating H3K79me2\/3 methylation in macrophages","volume":"17","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"2025101515351191000_2025.10.10.681723v1.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920372117"},{"issue":"2","key":"2025101515351191000_2025.10.10.681723v1.12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.immuni.2019.06.015","article-title":"The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair","volume":"51","year":"2019","journal-title":"Immunity"},{"key":"2025101515351191000_2025.10.10.681723v1.13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170928"},{"key":"2025101515351191000_2025.10.10.681723v1.14","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4043"},{"issue":"70","key":"2025101515351191000_2025.10.10.681723v1.15","doi-asserted-by":"crossref","first-page":"114442","DOI":"10.18632\/oncotarget.17748","article-title":"Identification of the histone lysine demethylase KDM4A\/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"2025101515351191000_2025.10.10.681723v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.02.007"},{"key":"2025101515351191000_2025.10.10.681723v1.17","doi-asserted-by":"crossref","unstructured":"Wang L , Oh TG , Magida J , Estepa G , Obayomi SMB , Chong LW , et al. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021;118(35).","DOI":"10.1073\/pnas.2109517118"},{"key":"2025101515351191000_2025.10.10.681723v1.18","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1293"},{"key":"2025101515351191000_2025.10.10.681723v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110570108"},{"key":"2025101515351191000_2025.10.10.681723v1.20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz178"},{"key":"2025101515351191000_2025.10.10.681723v1.21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86114"},{"key":"2025101515351191000_2025.10.10.681723v1.22","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-89512-3_14"},{"key":"2025101515351191000_2025.10.10.681723v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.11.020"},{"issue":"2","key":"2025101515351191000_2025.10.10.681723v1.24","first-page":"262","article-title":"Notch signalling in T-cell lymphoblastic leukaemia\/lymphoma and other haematological malignancies","volume":"223","year":"2011","journal-title":"J Pathol"},{"key":"2025101515351191000_2025.10.10.681723v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2304"},{"key":"2025101515351191000_2025.10.10.681723v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00953-2"},{"key":"2025101515351191000_2025.10.10.681723v1.27","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0269"},{"key":"2025101515351191000_2025.10.10.681723v1.28","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS18-4160"},{"key":"2025101515351191000_2025.10.10.681723v1.29","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0518-7"},{"key":"2025101515351191000_2025.10.10.681723v1.30","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw193"},{"issue":"7","key":"2025101515351191000_2025.10.10.681723v1.31","doi-asserted-by":"crossref","first-page":"e0180143","DOI":"10.1371\/journal.pone.0180143","article-title":"Boosting efferocytosis in alveolar space using BCG vaccine to protect host against influenza pneumonia","volume":"12","year":"2017","journal-title":"PLoS One"},{"key":"2025101515351191000_2025.10.10.681723v1.32","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0313161"},{"key":"2025101515351191000_2025.10.10.681723v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.10.015"},{"key":"2025101515351191000_2025.10.10.681723v1.34","doi-asserted-by":"crossref","unstructured":"Knuth AK , Huard A , Naeem Z , Rappl P , Bauer R , Mota AC , et al. Apoptotic Cells induce Proliferation of Peritoneal Macrophages. Int J Mol Sci. 2021;22(5).","DOI":"10.3390\/ijms22052230"},{"key":"2025101515351191000_2025.10.10.681723v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature05877"},{"issue":"3","key":"2025101515351191000_2025.10.10.681723v1.36","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1148\/radiology.173.3.2813796","article-title":"Squamous cell carcinoma of the uroepithelium: CT evaluation","volume":"173","year":"1989","journal-title":"Radiology"},{"key":"2025101515351191000_2025.10.10.681723v1.37","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1989"},{"key":"2025101515351191000_2025.10.10.681723v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.005"},{"key":"2025101515351191000_2025.10.10.681723v1.39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.167197"},{"key":"2025101515351191000_2025.10.10.681723v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.07.015"},{"key":"2025101515351191000_2025.10.10.681723v1.41","doi-asserted-by":"publisher","DOI":"10.1101\/gad.211912.112"},{"key":"2025101515351191000_2025.10.10.681723v1.42","doi-asserted-by":"crossref","unstructured":"Kopan R . Notch signaling. Cold Spring Harb Perspect Biol. 2012;4(10).","DOI":"10.1101\/cshperspect.a011213"},{"key":"2025101515351191000_2025.10.10.681723v1.43","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22873"},{"key":"2025101515351191000_2025.10.10.681723v1.44","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2843"},{"key":"2025101515351191000_2025.10.10.681723v1.45","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-562710"},{"key":"2025101515351191000_2025.10.10.681723v1.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915000107"},{"key":"2025101515351191000_2025.10.10.681723v1.47","doi-asserted-by":"publisher","DOI":"10.1186\/cc1861"},{"key":"2025101515351191000_2025.10.10.681723v1.48","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0211062"},{"issue":"2","key":"2025101515351191000_2025.10.10.681723v1.49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1365-2249.2010.04175.x","article-title":"Acute lung injury: apoptosis in effector and target cells of the upper and lower airway compartment","volume":"161","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"2025101515351191000_2025.10.10.681723v1.50","first-page":"41","article-title":"Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases","volume":"3","year":"2010","journal-title":"J Cell Death"},{"key":"2025101515351191000_2025.10.10.681723v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.018"},{"key":"2025101515351191000_2025.10.10.681723v1.52","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3325"},{"issue":"1","key":"2025101515351191000_2025.10.10.681723v1.53","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/10799893.2012.752002","article-title":"The STAR of the DLC family","volume":"33","year":"2013","journal-title":"J Recept Signal Transduct Res"},{"key":"2025101515351191000_2025.10.10.681723v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15353"},{"key":"2025101515351191000_2025.10.10.681723v1.55","doi-asserted-by":"crossref","unstructured":"Gosselin D , Skola D , Coufal NG , Holtman IR , Schlachetzki JCM , Sajti E , et al. An environment-dependent transcriptional network specifies human microglia identity. Science. 2017;356(6344).","DOI":"10.1126\/science.aal3222"},{"issue":"6","key":"2025101515351191000_2025.10.10.681723v1.56","doi-asserted-by":"crossref","first-page":"e0233880","DOI":"10.1371\/journal.pone.0233880","article-title":"siRNA inhibition and not chemical inhibition of Suv39h1\/2 enhances pre-implantation embryonic development of bovine somatic cell nuclear transfer embryos","volume":"15","year":"2020","journal-title":"PLoS One"},{"key":"2025101515351191000_2025.10.10.681723v1.57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72051"},{"key":"2025101515351191000_2025.10.10.681723v1.58","doi-asserted-by":"publisher","DOI":"10.4161\/21541248.2014.989785"},{"key":"2025101515351191000_2025.10.10.681723v1.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.001"},{"key":"2025101515351191000_2025.10.10.681723v1.60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90520"},{"key":"2025101515351191000_2025.10.10.681723v1.61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jvssci.2021.11.002","article-title":"Vascular smooth muscle cell phenotype switching in carotid atherosclerosis","volume":"3","year":"2022","journal-title":"JVS Vasc Sci"},{"key":"2025101515351191000_2025.10.10.681723v1.62","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E03-02-0063"},{"key":"2025101515351191000_2025.10.10.681723v1.63","doi-asserted-by":"publisher","DOI":"10.4161\/cam.5.2.14403"},{"key":"2025101515351191000_2025.10.10.681723v1.64","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200586"},{"key":"2025101515351191000_2025.10.10.681723v1.65","first-page":"473","volume":"325","year":"2009","journal-title":"A gene network regulating lysosomal biogenesis and function. Science"},{"key":"2025101515351191000_2025.10.10.681723v1.66","doi-asserted-by":"crossref","unstructured":"DeBerge M , Lantz C , Dehn S , Sullivan DP , van der Laan AM , Niessen HWM , et al. Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair. J Exp Med. 2021;218(9).","DOI":"10.1084\/jem.20200667"},{"key":"2025101515351191000_2025.10.10.681723v1.67","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315627"},{"issue":"2","key":"2025101515351191000_2025.10.10.681723v1.68","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.immuni.2019.06.015","article-title":"The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair","volume":"51","year":"2019","journal-title":"Immunity"},{"key":"2025101515351191000_2025.10.10.681723v1.69","doi-asserted-by":"crossref","unstructured":"Travers JG , Wennersten SA , Pena B , Bagchi RA , Smith HE , Hirsch RA , et al. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021.","DOI":"10.1161\/CIRCULATIONAHA.120.046462"},{"key":"2025101515351191000_2025.10.10.681723v1.70","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1983711"},{"key":"2025101515351191000_2025.10.10.681723v1.71","doi-asserted-by":"publisher","DOI":"10.1101\/gad.563210"},{"key":"2025101515351191000_2025.10.10.681723v1.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.07.020"},{"key":"2025101515351191000_2025.10.10.681723v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.04.020"},{"key":"2025101515351191000_2025.10.10.681723v1.74","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796525"},{"key":"2025101515351191000_2025.10.10.681723v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.08.022"},{"key":"2025101515351191000_2025.10.10.681723v1.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.037"},{"key":"2025101515351191000_2025.10.10.681723v1.77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709501200"},{"key":"2025101515351191000_2025.10.10.681723v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.035"},{"key":"2025101515351191000_2025.10.10.681723v1.79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.584144"},{"key":"2025101515351191000_2025.10.10.681723v1.80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202071109"},{"key":"2025101515351191000_2025.10.10.681723v1.81","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90163-7"},{"key":"2025101515351191000_2025.10.10.681723v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61861-6"},{"key":"2025101515351191000_2025.10.10.681723v1.83","doi-asserted-by":"publisher","DOI":"10.1038\/nature01148"},{"key":"2025101515351191000_2025.10.10.681723v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)00004-1"},{"issue":"1","key":"2025101515351191000_2025.10.10.681723v1.85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12964-020-00635-5","article-title":"Differential regulation of rho GTPases during lung adenocarcinoma migration and invasion reveals a novel role of the tumor suppressor StarD13 in invadopodia regulation","volume":"18","year":"2020","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2025101515351191000_2025.10.10.681723v1.86","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3892\/or.2013.2861","article-title":"Effect of StarD13 on colorectal cancer proliferation, motility and invasion","volume":"31","year":"2014","journal-title":"Oncol Rep"},{"key":"2025101515351191000_2025.10.10.681723v1.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.11.023"},{"key":"2025101515351191000_2025.10.10.681723v1.88","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.12.1.463"},{"key":"2025101515351191000_2025.10.10.681723v1.89","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90370-4"},{"key":"2025101515351191000_2025.10.10.681723v1.90","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306079200"},{"key":"2025101515351191000_2025.10.10.681723v1.91","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00047-1"},{"key":"2025101515351191000_2025.10.10.681723v1.92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803677105"},{"key":"2025101515351191000_2025.10.10.681723v1.93","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9623"},{"key":"2025101515351191000_2025.10.10.681723v1.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.057"},{"key":"2025101515351191000_2025.10.10.681723v1.95","doi-asserted-by":"publisher","DOI":"10.3791\/50966"},{"key":"2025101515351191000_2025.10.10.681723v1.96","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00896.2013"},{"key":"2025101515351191000_2025.10.10.681723v1.97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212324110"},{"key":"2025101515351191000_2025.10.10.681723v1.98","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio721"},{"key":"2025101515351191000_2025.10.10.681723v1.99","doi-asserted-by":"publisher","DOI":"10.1038\/nature11260"},{"key":"2025101515351191000_2025.10.10.681723v1.100","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046038"},{"key":"2025101515351191000_2025.10.10.681723v1.101","doi-asserted-by":"crossref","unstructured":"Vasamsetti SB , Coppin E , Zhang X , Florentin J , Koul S , Gotberg M , et al. Apoptosis of hematopoietic progenitor-derived adipose tissue-resident macrophages contributes to insulin resistance after myocardial infarction. Sci Transl Med. 2020;12(553).","DOI":"10.1126\/scitranslmed.aaw0638"},{"key":"2025101515351191000_2025.10.10.681723v1.102","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"2025101515351191000_2025.10.10.681723v1.103","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.68"},{"key":"2025101515351191000_2025.10.10.681723v1.104","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2332"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.10.10.681723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:45:59Z","timestamp":1768470359000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.10.10.681723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,12]]},"references-count":104,"URL":"https:\/\/doi.org\/10.1101\/2025.10.10.681723","relation":{},"subject":[],"published":{"date-parts":[[2025,10,12]]},"subtype":"preprint"}}