{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:59:52Z","timestamp":1793926792878,"version":"4.8.0"},"posted":{"date-parts":[[2025,10,15]]},"group-title":"Neuroscience","reference-count":86,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["950-231964"],"award-info":[{"award-number":["950-231964"]}],"id":[{"id":"https:\/\/ror.org\/0517h6h17","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RGPIN-2023-05558"],"award-info":[{"award-number":["RGPIN-2023-05558"]}],"id":[{"id":"https:\/\/ror.org\/01h531d29","id-type":"ROR","asserted-by":"publisher"}]},{"award":["37427"],"award-info":[{"award-number":["37427"]}],"id":[{"id":"https:\/\/ror.org\/000az4664","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Alzheimer\u2019s disease (AD) is a progressive and debilitating neurodegenerative disease of the central nervous system, characterized by deterioration in cognitive function including extensive memory impairment. The hippocampus, a medial temporal lobe region, is a key orchestrator in the encoding and retrieval of memory and is believed to be one of the first regions to deteriorate in AD. In this work we examined hippocampal macrostructure (specifically gyrification and thickness) and microstructure in Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI) relative to healthy aged controls in the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) dataset. We first utilized an iterative training paradigm to adapt an existing deep learning approach for capturing hippocampal topology to elderly individuals as well as individuals with potential hippocampal degeneration. Using this new model, we found notable decreases in both thickness and gyrification in AD and MCI across both the subfields and anterior-posterior axis. Using the diffusion tensor representation derived from diffusion MRI data, we found significant increases in the mean diffusivity across the extent of the hippocampus in AD and MCI, which may be related to a number of changes such as loss of neuronal cells, decreased fiber density, demyelination, and increased presence of CSF. Examining the primary direction of diffusion relative to canonical hippocampal axes, we found distinct diffusion orientation shifts in AD and MCI throughout the anterior-posterior extent of the subiculum and CA1. Specifically, we found a decrease in diffusion oriented tangentially, and an increase in diffusion oriented along the long-axis. This could potentially be related to the known degeneration of the perforant path, which is greatly affected in AD and is a largely tangential oriented pathway. The AD-related changes in diffusion orientations were found to not have significant spatial overlap with AD-related changes in mean diffusivity, suggesting that they may be capturing distinct spatially-localized disease processes. Finally, we showed that the macro- and microstructure of the hippocampus in AD changed less across age relative to MCI and controls. As well, the age-related hippocampal macrostructure changes in MCI appeared indistinguishable from healthy aging.<\/jats:p>","DOI":"10.1101\/2025.10.15.682705","type":"posted-content","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T04:55:27Z","timestamp":1760590527000},"source":"Crossref","is-referenced-by-count":1,"title":["Hippocampal grey matter changes across scales in Alzheimer\u2019s Disease"],"prefix":"10.64898","author":[{"given":"Bradley G.","family":"Karat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh Varvani","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Thurairajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor W.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025101722201557000_2025.10.15.682705v1.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049072"},{"key":"2025101722201557000_2025.10.15.682705v1.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801093115"},{"key":"2025101722201557000_2025.10.15.682705v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.019"},{"key":"2025101722201557000_2025.10.15.682705v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.01.010"},{"key":"2025101722201557000_2025.10.15.682705v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"2025101722201557000_2025.10.15.682705v1.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"2025101722201557000_2025.10.15.682705v1.7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"issue":"3","key":"2025101722201557000_2025.10.15.682705v1.8","first-page":"1007","article-title":"Diffusion changes in hippocampal cingulum in early biologically defined Alzheimer\u2019s disease","volume":"91","year":"2022","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"2025101722201557000_2025.10.15.682705v1.9","doi-asserted-by":"crossref","unstructured":"DeKraker, J. , Haast, R. A. , Yousif, M. D. , Karat, B. , Lau, J. C. , K\u00f6hler, S. , & Khan, A. R . (2022). Automated hippocampal unfolding for morphometry and subfield segmentation with Hippunfold. eLife, 11.","DOI":"10.7554\/eLife.77945"},{"key":"2025101722201557000_2025.10.15.682705v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116328"},{"key":"2025101722201557000_2025.10.15.682705v1.11","doi-asserted-by":"crossref","unstructured":"DeKraker, J. , Palomero-Gallagher, N. , Kedo, O. , Ladbon-Bernasconi, N. , Muenzing, S. E. , Axer, M. , Amunts, K. , Khan, A. R. , Bernhardt, B. C. , & Evans, A. C . (2023). Evaluation of surface-based hippocampal registration using ground-truth subfield definitions. eLife, 12.","DOI":"10.7554\/eLife.88404.4"},{"issue":"12","key":"2025101722201557000_2025.10.15.682705v1.12","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1002\/hbm.23773","article-title":"Complexity analysis of cortical surface detects changes in future Alzheimer\u2019s disease converters","volume":"38","year":"2017","journal-title":"Human Brain Mapping"},{"key":"2025101722201557000_2025.10.15.682705v1.13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23786"},{"key":"2025101722201557000_2025.10.15.682705v1.14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980817)398:1<25::AID-CNE3>3.0.CO;2-B"},{"key":"2025101722201557000_2025.10.15.682705v1.15","doi-asserted-by":"crossref","unstructured":"Duvernoy, H. M. , Cattin, F. , Risold, P.-Y. , Vannson, J. L. , & Gaudron, M . (2013). The human hippocampus: Functional anatomy, vascularization, and serial sections with MRI. Springer.","DOI":"10.1007\/978-3-642-33603-4"},{"issue":"s3","key":"2025101722201557000_2025.10.15.682705v1.16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3233\/JAD-2011-0001","article-title":"Diffusion Tensor Imaging of the Hippocampus in MCI and Early Alzheimer\u2019s Disease","volume":"26","year":"2011","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"2025101722201557000_2025.10.15.682705v1.17","doi-asserted-by":"crossref","unstructured":"Feng, Y. , Chandio, B. Q. , Villalon-Reina, J. E. , Thomopoulos, S. I. , Nir, T. M. , Benavidez, S. , Laltoo, E. , Chattopadhyay, T. , Joshi, H. , Venkatasubramanian, G. , John, J. P. , Jahanshad, N. , Reid, R. I. , Jack, C. R. , Weiner, M. W. , & Thompson, P. M. (2024). Microstructural mapping of neural pathways in Alzheimer\u2019s disease using macrostructure-informed normative tractometry. Alzheimer\u2019s & Dementia.","DOI":"10.1101\/2024.04.25.591183"},{"key":"2025101722201557000_2025.10.15.682705v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.11.002"},{"key":"2025101722201557000_2025.10.15.682705v1.19","doi-asserted-by":"publisher","DOI":"10.2307\/1164979"},{"issue":"4","key":"2025101722201557000_2025.10.15.682705v1.20","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3233\/JAD-200661","article-title":"Axonal Conduction Velocity in CA1 Area of Hippocampus is Reduced in Mouse Models of Alzheimer\u2019s Disease","volume":"77","year":"2020","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"2025101722201557000_2025.10.15.682705v1.21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-14-04491.1996"},{"issue":"11","key":"2025101722201557000_2025.10.15.682705v1.22","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jalz.2018.01.010","article-title":"CSF biomarkers of Alzheimer\u2019s disease concord with amyloid-\u03b2 PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts","volume":"14","year":"2018","journal-title":"Alzheimers & Dementia"},{"key":"2025101722201557000_2025.10.15.682705v1.23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4521-10.2010"},{"key":"2025101722201557000_2025.10.15.682705v1.24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042325"},{"issue":"7","key":"2025101722201557000_2025.10.15.682705v1.25","first-page":"1215","article-title":"Microstructural changes in the hippocampus and posterior cingulate in mild cognitive impairment and Alzheimer\u2019s disease: a diffusion tensor imaging study","volume":"34","year":"2012","journal-title":"Neurological Sciences"},{"issue":"1","key":"2025101722201557000_2025.10.15.682705v1.26","first-page":"58","article-title":"Prediction of Alzheimer\u2019s disease pathophysiology based on cortical thickness patterns. Alzheimer\u2019s & Dementia: Diagnosis","volume":"2","year":"2016","journal-title":"Assessment & Disease Monitoring"},{"key":"2025101722201557000_2025.10.15.682705v1.27","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200406"},{"issue":"2","key":"2025101722201557000_2025.10.15.682705v1.28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41592-020-01008-z","article-title":"NNU-net: A self-configuring method for deep learning-based biomedical image segmentation","volume":"18","year":"2021","journal-title":"Nature Methods"},{"key":"2025101722201557000_2025.10.15.682705v1.29","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21049"},{"key":"2025101722201557000_2025.10.15.682705v1.30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.5.957"},{"key":"2025101722201557000_2025.10.15.682705v1.31","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3785"},{"key":"2025101722201557000_2025.10.15.682705v1.32","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26461"},{"key":"2025101722201557000_2025.10.15.682705v1.33","doi-asserted-by":"crossref","unstructured":"Karat, B. , Kohler, S. , & Khan, A . (2024a). Diffusion MRI of the hippocampus. Journal of Neuroscience, 44(23).","DOI":"10.1523\/JNEUROSCI.1705-23.2024"},{"key":"2025101722201557000_2025.10.15.682705v1.34","doi-asserted-by":"crossref","unstructured":"Karat, B. G. , Genc, S. , Raven, E. P. , Palombo, M. , Khan, A. R. , & Jones, D. K . (2024b). The Developing Hippocampus: Microstructural Evolution through Childhood and Adolescence. bioRxiv.","DOI":"10.1101\/2024.08.19.608590"},{"key":"2025101722201557000_2025.10.15.682705v1.35","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2072"},{"key":"2025101722201557000_2025.10.15.682705v1.36","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26054"},{"key":"2025101722201557000_2025.10.15.682705v1.37","unstructured":"Khan, A. R. , Kai, J. , Van Dyken, P. , & Karat, B. G (2023a): Akhanf\/snakedwi; 0.2.1, (v0.2.1). Zenodo."},{"key":"2025101722201557000_2025.10.15.682705v1.38","unstructured":"Khan, A. R. , Kai, J. , Van Dyken, P. , Kuehn, T. , & Gau, R. (2023b): Akhanf\/snakebids; 0.7.2, (v0.7.2). Zenodo."},{"key":"2025101722201557000_2025.10.15.682705v1.39","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"2025101722201557000_2025.10.15.682705v1.40","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2012.2230640"},{"key":"2025101722201557000_2025.10.15.682705v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.049"},{"key":"2025101722201557000_2025.10.15.682705v1.42","doi-asserted-by":"crossref","unstructured":"Lee, P. , Kim, H.-R. , & Jeong, Y . (2020). Detection of gray matter microstructural changes in Alzheimer\u2019s disease continuum using fiber orientation. BMC Neurology, 20(1).","DOI":"10.1186\/s12883-020-01939-2"},{"key":"2025101722201557000_2025.10.15.682705v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4661"},{"key":"2025101722201557000_2025.10.15.682705v1.44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031083"},{"key":"2025101722201557000_2025.10.15.682705v1.45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4136-10.2010"},{"key":"2025101722201557000_2025.10.15.682705v1.46","doi-asserted-by":"crossref","unstructured":"Masters, C. L. , Bateman, R. , Blennow, K. , Rowe, C. C. , Sperling, R. A. , & Cummings, J. L . (2015). Alzheimer\u2019s disease. Nature Reviews Disease Primers, 1(1).","DOI":"10.1038\/nrdp.2015.56"},{"issue":"2","key":"2025101722201557000_2025.10.15.682705v1.47","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/mrm.1910370226","article-title":"The B matrix in diffusion tensor echo-planar imaging","volume":"37","year":"1997","journal-title":"Magnetic Resonance in Medicine"},{"key":"2025101722201557000_2025.10.15.682705v1.48","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"2025101722201557000_2025.10.15.682705v1.49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12688\/f1000research.29032.2","article-title":"Sustainable data analysis with Snakemake","volume":"10","year":"2021","journal-title":"F1000Research"},{"issue":"3","key":"2025101722201557000_2025.10.15.682705v1.50","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pscychresns.2006.01.005","article-title":"Diffusion tensor imaging in early Alzheimer\u2019s disease","volume":"146","year":"2006","journal-title":"Psychiatry Research Neuroimaging"},{"key":"2025101722201557000_2025.10.15.682705v1.51","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0826-y"},{"key":"2025101722201557000_2025.10.15.682705v1.52","doi-asserted-by":"crossref","unstructured":"Nieuwenhuys, R. , Voogd, J. , & Huijzen, C. (2008). The Human Central Nervous System. Springer Berlin Heidelberg.","DOI":"10.1007\/978-3-540-34686-9"},{"key":"2025101722201557000_2025.10.15.682705v1.53","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25741"},{"key":"2025101722201557000_2025.10.15.682705v1.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021745"},{"issue":"2","key":"2025101722201557000_2025.10.15.682705v1.55","first-page":"336","article-title":"Simultaneous Measurement of \u03b2-Amyloid(1\u201342), Total Tau, and Phosphorylated Tau (Thr181) in Cerebrospinal Fluid by the xMAP Technology","volume":"51","year":"2004","journal-title":"Clinical Chemistry"},{"key":"2025101722201557000_2025.10.15.682705v1.56","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp105"},{"issue":"2","key":"2025101722201557000_2025.10.15.682705v1.57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000446770","article-title":"Altered Superficial White Matter on Tractography MRI in Alzheimer\u2019s Disease","volume":"6","year":"2016","journal-title":"Dementia and Geriatric Cognitive Disorders Extra"},{"key":"2025101722201557000_2025.10.15.682705v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.03.013"},{"issue":"1","key":"2025101722201557000_2025.10.15.682705v1.59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/2515245918808784","article-title":"An Updated Recommendation for Multiple Comparisons","volume":"2","year":"2019","journal-title":"Advances in Methods and Practices in Psychological Science"},{"key":"2025101722201557000_2025.10.15.682705v1.60","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"2025101722201557000_2025.10.15.682705v1.61","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.20.1.11"},{"issue":"6","key":"2025101722201557000_2025.10.15.682705v1.62","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/brain\/awac138","article-title":"Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer\u2019s disease","volume":"145","year":"2022","journal-title":"Brain"},{"key":"2025101722201557000_2025.10.15.682705v1.63","doi-asserted-by":"crossref","first-page":"103002","DOI":"10.1016\/j.nicl.2022.103002","article-title":"Diffusion tensor tractography of the fornix in cerebral amyloid angiopathy, mild cognitive impairment and Alzheimer\u2019s disease","volume":"34","year":"2022","journal-title":"NeuroImage Clinical"},{"key":"2025101722201557000_2025.10.15.682705v1.64","doi-asserted-by":"crossref","first-page":"103318","DOI":"10.1016\/j.nicl.2023.103318","article-title":"Microstructural mapping of dentate gyrus pathology in Alzheimer\u2019s disease: A 16.4 Tesla MRI study","volume":"37","year":"2023","journal-title":"NeuroImage: Clinical"},{"key":"2025101722201557000_2025.10.15.682705v1.65","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl256"},{"key":"2025101722201557000_2025.10.15.682705v1.66","doi-asserted-by":"crossref","unstructured":"Smith, S. M. , Jenkinson, M. , Woolrich, M. W. , Beckmann, C. F. , Behrens, T. E. J. , Johansen-Berg, H. , Bannister, P. R. , De Luca, M. , Drobnjak, I. , Flitney, D. E. , Niazy, R. K. , Saunders, J. , Vickers, J. , Zhang, Y. , De Stefano, N. , Brady, J. M. , & Matthews, P. M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage, 23.","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"issue":"3","key":"2025101722201557000_2025.10.15.682705v1.67","first-page":"961","article-title":"Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer\u2019s disease","volume":"147","year":"2023","journal-title":"Brain"},{"issue":"1","key":"2025101722201557000_2025.10.15.682705v1.68","first-page":"6","article-title":"The legacy of patient H","volume":"61","year":"2010","journal-title":"M. for Neuroscience. Neuron"},{"key":"2025101722201557000_2025.10.15.682705v1.69","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/915041"},{"key":"2025101722201557000_2025.10.15.682705v1.70","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8106"},{"issue":"8","key":"2025101722201557000_2025.10.15.682705v1.71","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.mri.2016.05.001","article-title":"Shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in Alzheimer\u2019s disease","volume":"34","year":"2016","journal-title":"Magnetic Resonance Imaging"},{"key":"2025101722201557000_2025.10.15.682705v1.72","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"2025101722201557000_2025.10.15.682705v1.73","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1379.017"},{"key":"2025101722201557000_2025.10.15.682705v1.74","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2019.116137"},{"key":"2025101722201557000_2025.10.15.682705v1.75","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2046908"},{"key":"2025101722201557000_2025.10.15.682705v1.76","doi-asserted-by":"crossref","unstructured":"Van Hoesen, G. W. , & Hyman, B. T. (1990). Hippocampal formation: anatomy and the patterns of pathology in Alzheimer\u2019s disease. Progress in Brain Research, 445\u2013457.","DOI":"10.1016\/S0079-6123(08)61268-6"},{"key":"2025101722201557000_2025.10.15.682705v1.77","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26059"},{"key":"2025101722201557000_2025.10.15.682705v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92338-8"},{"key":"2025101722201557000_2025.10.15.682705v1.79","doi-asserted-by":"crossref","unstructured":"Weston, P. S. J. , Simpson, I. J. A. , Ryan, N. S. , Ourselin, S. , & Fox, N. C . (2015). Diffusion imaging changes in grey matter in Alzheimer\u2019s disease: a potential marker of early neurodegeneration. Alzheimer\u2019s Research & Therapy, 7(1).","DOI":"10.1186\/s13195-015-0132-3"},{"key":"2025101722201557000_2025.10.15.682705v1.80","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000174061.41897.ee"},{"issue":"5","key":"2025101722201557000_2025.10.15.682705v1.81","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.neuropsychologia.2010.01.014","article-title":"Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer\u2019s disease","volume":"48","year":"2010","journal-title":"Neuropsychologia"},{"key":"2025101722201557000_2025.10.15.682705v1.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002113107"},{"issue":"4","key":"2025101722201557000_2025.10.15.682705v1.83","doi-asserted-by":"crossref","first-page":"640","DOI":"10.9758\/cpn.2021.19.4.640","article-title":"Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment","volume":"19","year":"2021","journal-title":"Clinical Psychopharmacology and Neuroscience"},{"key":"2025101722201557000_2025.10.15.682705v1.84","doi-asserted-by":"crossref","unstructured":"Yushkevich, P. A. , Pluta, J. , Wang, H. , Wisse, L. E. M. , Das, S. , & Wolk, D . (2016). IC-P-174: Fast Automatic Segmentation of Hippocampal Subfields and Medial Temporal Lobe Subregions In 3 Tesla and 7 Tesla T2-Weighted MRI. Alzheimer\u2019s & Dementia, 12.","DOI":"10.1016\/j.jalz.2016.06.205"},{"key":"2025101722201557000_2025.10.15.682705v1.85","doi-asserted-by":"crossref","unstructured":"Zeineh, M. M. , Palomero-Gallagher, N. , Axer, M. , Gr\u00e4bel, D. , Goubran, M. , Wree, A. , Woods, R. , Amunts, K. , & Zilles, K . (2017). Direct visualization and mapping of the spatial course of fiber tracts at microscopic resolution in the Human Hippocampus. Cerebral Cortex.","DOI":"10.1093\/cercor\/bhw010"},{"key":"2025101722201557000_2025.10.15.682705v1.86","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp071"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.10.15.682705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:49:13Z","timestamp":1768470553000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.10.15.682705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":86,"URL":"https:\/\/doi.org\/10.1101\/2025.10.15.682705","relation":{},"subject":[],"published":{"date-parts":[[2025,10,15]]},"subtype":"preprint"}}