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We identified 91 genetic loci associated with ADRD risk, including 16 which are novel, and 56 which are specifically detected in clinically diagnosed AD cases. We also provide a list of 18 loci (15 novel) requiring further external validation. A polygenic score combining the effect of the ADRD loci except\n                  <jats:italic>APOE<\/jats:italic>\n                  was primarily associated with AD rather than non-AD pathology. Individuals in the 10\n                  <jats:sup>th<\/jats:sup>\n                  decile of the score had a 2-fold increased risk to present with Braak neurofibrillary tangles stage above 5 and moderate\/severe neuritic amyloid plaque pathology at death compared to individuals in the median score group.\n                <\/jats:p>","DOI":"10.1101\/2025.10.20.25338060","type":"posted-content","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:25:14Z","timestamp":1761251114000},"source":"Crossref","is-referenced-by-count":3,"title":["Consensus meta-analysis of genome-wide association studies for Alzheimer\u2019s disease and related dementia"],"prefix":"10.64898","author":[{"name":"ADGC","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Bonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHARGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EADB","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Bellenguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EADI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FinnGen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GERAD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GR@ACE\/DEGESCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PGC-ALZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025102506450574000_2025.10.20.25338060v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2802"},{"key":"2025102506450574000_2025.10.20.25338060v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0358-2"},{"key":"2025102506450574000_2025.10.20.25338060v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/S41588-018-0311-9"},{"key":"2025102506450574000_2025.10.20.25338060v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22491-8"},{"key":"2025102506450574000_2025.10.20.25338060v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00921-z"},{"key":"2025102506450574000_2025.10.20.25338060v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"2025102506450574000_2025.10.20.25338060v1.7","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1038\/s41380-023-02076-1","article-title":"Step by step: towards a better understanding of the genetic architecture of Alzheimer\u2019s disease","volume":"28","year":"2023","journal-title":"Mol. 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