{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:43:42Z","timestamp":1768571022041,"version":"3.49.0"},"posted":{"date-parts":[[2025,10,24]]},"group-title":"Public and Global Health","reference-count":65,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>INTRODUCTION<\/jats:title>\n                  <jats:p>Vascular risk factors contribute to cognitive decline and dementia; however, research across populations remains scarce.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We included 402 participants (mean age 57.9\u00b13.8, 58.5% female, 52% Mexican American). Midlife cardiovascular health was assessed using the AHA Life\u2019s Simple 7 (LS7). General cognition was measured four times over a period of 9.5 years. We used generalized estimating equations to assess the association of LS7 scores and its factors with cognitive change, overall and by ethnicity.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>\n                    Meeting intermediate or ideal physical activity goals mitigated cognitive decline, particularly in Mexican Americans, and maintaining blood glucose below 125 mg\/dL was associated with slower cognitive decline among non-Hispanic Whites. Additionally, Mexican Americans with a BMI &lt;30 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    showed an accelerated cognitive decline. No associations were observed between total LS7 scores and cognitive decline.\n                  <\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>DISCUSSION<\/jats:title>\n                  <jats:p>Physical activity, blood glucose, and BMI have distinct contributions to cognitive change across different ethnicities.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.10.23.25338553","type":"posted-content","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:05:44Z","timestamp":1761350744000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-5045","authenticated-orcid":false,"given":"Janette","family":"Vazquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus D.","family":"Melgarejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Maestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-2622","authenticated-orcid":false,"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen P.","family":"Hazuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Pin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-4430","authenticated-orcid":false,"given":"Claudia L.","family":"Satizabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2025102710200596000_2025.10.23.25338553v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"2025102710200596000_2025.10.23.25338553v1.2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000010022"},{"key":"2025102710200596000_2025.10.23.25338553v1.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"2025102710200596000_2025.10.23.25338553v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"2025102710200596000_2025.10.23.25338553v1.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70537-3"},{"issue":"2","key":"2025102710200596000_2025.10.23.25338553v1.6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/joim.13657","article-title":"The age-dependent association of Life\u2019s Simple 7 with transitions across cognitive states after age 60","volume":"294","year":"2023","journal-title":"J Intern Med"},{"key":"2025102710200596000_2025.10.23.25338553v1.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192703"},{"key":"2025102710200596000_2025.10.23.25338553v1.8","doi-asserted-by":"crossref","unstructured":"Nordestgaard LT , Christoffersen M , Frikke-Schmidt R. 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