{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:47:10Z","timestamp":1790293630390,"version":"4.1.0"},"posted":{"date-parts":[[2025,10,30]]},"group-title":"Neurology","reference-count":43,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Remote, smartphone-based cognitive testing may improve access to cognitive assessments for Alzheimer\u2019s disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone-based cognitive tests in a registry-based cohort.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adults without a record of cognitive impairment (N=1,815; ages 18-92) were recruited from the UCSF Brain Health Registry to complete unsupervised ALLFTD-mApp cognitive tasks three times over two weeks. Reliability was assessed with correlations between sessions. Linear regression models tested associations of ALLFTD-mApp tasks with demographics, self- and informant-rated cognitive concerns (Everyday Cognition Surveys; ECog), and web-based cognitive testing (CogState Brief Battery; CBB).<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Adherence was high (82.2%) and usability favorable. Test-retest reliability was moderate to strong (\u03c1s = 0.61\u20130.85, all ps &lt; .001). Lower ALLFTD-mApp scores were associated with older age, lower education, cognitive concerns, and worse CBB performance.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Findings support the feasibility, reliability, and validity of the ALLFTD-mApp in adults without a record of cognitive impairment.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.10.28.25338686","type":"posted-content","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:20:16Z","timestamp":1761859216000},"source":"Crossref","is-referenced-by-count":2,"title":["Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings"],"prefix":"10.64898","author":[{"given":"Sreya","family":"Dhanam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sanderson-Cimino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Carson","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W.","family":"Paolillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Fregly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Kwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-9537","authenticated-orcid":false,"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary W.","family":"Heuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah K.","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4153-8187","authenticated-orcid":false,"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Scott","family":"Mackin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Nosheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-9805","authenticated-orcid":false,"given":"Adam M.","family":"Staffaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Brain Health Registry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025110109250721000_2025.10.28.25338686v1.1","unstructured":"Global Status Report on the Public Health Response to Dementia. 1st ed. 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