{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:09:39Z","timestamp":1768529379690,"version":"3.49.0"},"posted":{"date-parts":[[2025,11,5]]},"group-title":"Cell Biology","reference-count":85,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National institute of health","award":["F30 AG069329 (HMK), T32GM007356 (HMK), R01AR063650, R01AG059775 (LX), R01AR069000 (CTR), R01AR056702 (EMS), and P30 AR069655 (EMS)"],"award-info":[{"award-number":["F30 AG069329 (HMK), T32GM007356 (HMK), R01AR063650, R01AG059775 (LX), R01AR069000 (CTR), R01AR056702 (EMS), and P30 AR069655 (EMS)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Resting collecting lymphatic vessels (cLVs) sense edema in distal joints and initiate contractions via unknown mechanisms. Rheumatoid arthritis (RA) patients have lymphatic drainage deficiencies from affected joints, and defects in the synovial lymphatic system exacerbate inflammatory-erosive arthritis in animal models. To understand this, we generated\n                  <jats:italic>Efhd1<\/jats:italic>\n                  -CreER\n                  <jats:sup>T2<\/jats:sup>\n                  and\n                  <jats:italic>Myoc<\/jats:italic>\n                  -CreER\n                  <jats:sup>T2<\/jats:sup>\n                  mice for cell-specific genetic gain and loss of function studies. These mice were crossed with tdTomato reporter (Ai9) mice, and studies showed selective tamoxifen-induced transgene expression in CD31\n                  <jats:sup>\u2212<\/jats:sup>\n                  \/CD34\n                  <jats:sup>+<\/jats:sup>\n                  telocyte-like cells in knee and ankle synovium, and in networks physically associated with mast cells proximal to popliteal lymphatic vessels (PLVs). Consistent with the known loss of CD31\n                  <jats:sup>\u2212<\/jats:sup>\n                  \/CD34\n                  <jats:sup>+<\/jats:sup>\n                  telocyte in RA synovium, these cells were also decreased in TNF-tg knees and partially recovered by anti-TNF treatment. Ultrastructural and gene expression studies confirmed a distinct telocyte phenotype versus closely related fibroblasts.\n                  <jats:italic>In vivo<\/jats:italic>\n                  depletion studies in tamoxifen-treated\n                  <jats:italic>Efhd1<\/jats:italic>\n                  -CreER\n                  <jats:sup>T2<\/jats:sup>\n                  and\n                  <jats:italic>Myoc<\/jats:italic>\n                  -CreER\n                  <jats:sup>T2<\/jats:sup>\n                  mice crossed to diphtheria toxin alpha-floxed (DTA\n                  <jats:sup>flox<\/jats:sup>\n                  ) mice demonstrated telocyte requirements for physiologic lymphatic drainage and resolution of joint inflammation and focal erosions from zymosan-induced arthritis in the knee.\n                  <jats:italic>In vitro<\/jats:italic>\n                  studies demonstrated increased sensitivity to osmotic shock and decreased motility versus fibroblasts, and telocyte potential to differentiate into myofibroblasts on stiff matrix. Collectively, these findings support a model of joint homeostasis in which osmotic pressure-sensing telocyte networks extend from the synovium into mast cells proximal to joint-draining cLVs, and telocyte loss is associated with defects in the synovial lymphatic system and increased susceptibility to joint inflammation and structural damage from arthritis.\n                <\/jats:p>\n                <jats:sec>\n                  <jats:title>Teaser<\/jats:title>\n                  <jats:p>This study discovered a unique cell type (telocytes) responsible for draining inflammation from arthritic joints.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2025.11.03.685859","type":"posted-content","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:45:15Z","timestamp":1762339515000},"source":"Crossref","is-referenced-by-count":0,"title":["The Function of\n                  <i>Efhd1<\/i>\n                  <sup>+<\/sup>\n                  Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-4772","authenticated-orcid":false,"given":"Yue","family":"Peng","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mark Kenney","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy","family":"Kobryn","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Lydon","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"de Mesy Bentley","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-7766","authenticated-orcid":false,"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Korman","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Medicine, Division of Allergy, Immunology, Rheumatology, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-1219","authenticated-orcid":false,"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Medicine, Division of Allergy, Immunology, Rheumatology, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-9698","authenticated-orcid":false,"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research, University of Rochester Medical Center"},{"name":"Department of Pathology & Laboratory Medicine, University of Rochester Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"54368","reference":[{"key":"2026010508050463000_2025.11.03.685859v2.1","doi-asserted-by":"crossref","unstructured":"B. J. Mehrara et al., The emerging importance of lymphatics in health and disease: an NIH workshop report. J. Clin. Invest. 133, (2023).","DOI":"10.1172\/JCI171582"},{"key":"2026010508050463000_2025.11.03.685859v2.2","doi-asserted-by":"crossref","unstructured":"D. Negrini , Morphological, Mechanical and Hydrodynamic Aspects of Diaphragmatic Lymphatics. Biology (Basel) 11, (2022).","DOI":"10.3390\/biology11121803"},{"key":"2026010508050463000_2025.11.03.685859v2.3","doi-asserted-by":"publisher","DOI":"10.1113\/JP272088"},{"key":"2026010508050463000_2025.11.03.685859v2.4","first-page":"H57","article-title":"Contractile stimuli in collecting lymph vessels","volume":"233","year":"1977","journal-title":"Am. J. Physiol"},{"key":"2026010508050463000_2025.11.03.685859v2.5","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201812294"},{"key":"2026010508050463000_2025.11.03.685859v2.6","doi-asserted-by":"crossref","unstructured":"M. J. Davis , S. D. Zawieja , Pacemaking in the lymphatic system. J. Physiol., (2024).","DOI":"10.1113\/JP284752"},{"key":"2026010508050463000_2025.11.03.685859v2.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.27464"},{"key":"2026010508050463000_2025.11.03.685859v2.8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01098.2011"},{"key":"2026010508050463000_2025.11.03.685859v2.9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.90679.90672"},{"key":"2026010508050463000_2025.11.03.685859v2.10","doi-asserted-by":"crossref","unstructured":"M. J. Davis , C. D. Bertram , Control of lymphatic pacemaking and pumping by mechanobiological signals. J. Physiol., (2025).","DOI":"10.1113\/JP288477"},{"key":"2026010508050463000_2025.11.03.685859v2.11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0626fje"},{"key":"2026010508050463000_2025.11.03.685859v2.12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00137"},{"key":"2026010508050463000_2025.11.03.685859v2.13","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.205"},{"key":"2026010508050463000_2025.11.03.685859v2.14","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.joca.2022.04.003","article-title":"Role of synovial lymphatic function in osteoarthritis","volume":"30","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"2026010508050463000_2025.11.03.685859v2.15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708055200"},{"key":"2026010508050463000_2025.11.03.685859v2.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.24764"},{"key":"2026010508050463000_2025.11.03.685859v2.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.30421"},{"key":"2026010508050463000_2025.11.03.685859v2.18","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.016"},{"key":"2026010508050463000_2025.11.03.685859v2.19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903489"},{"key":"2026010508050463000_2025.11.03.685859v2.20","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/art.40047","article-title":"Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte\/Macrophage Egress","volume":"69","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2026010508050463000_2025.11.03.685859v2.21","first-page":"130","article-title":"Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow","volume":"65","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2026010508050463000_2025.11.03.685859v2.22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13075-019-2039-z","article-title":"iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis","volume":"21","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2026010508050463000_2025.11.03.685859v2.23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1237498"},{"key":"2026010508050463000_2025.11.03.685859v2.24","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/art.41311","article-title":"Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in Affected Hands of Patients With Active Rheumatoid Arthritis","volume":"72","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2026010508050463000_2025.11.03.685859v2.25","doi-asserted-by":"crossref","first-page":"745096","DOI":"10.3389\/fphys.2021.745096","article-title":"Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis","volume":"12","year":"2021","journal-title":"Front. Physiol"},{"key":"2026010508050463000_2025.11.03.685859v2.26","doi-asserted-by":"crossref","first-page":"12751","DOI":"10.1038\/s41598-022-16884-y","article-title":"Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy","volume":"12","year":"2022","journal-title":"Scientific Reports"},{"key":"2026010508050463000_2025.11.03.685859v2.27","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3389\/fimmu.2020.01234","article-title":"Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology","volume":"11","year":"2020","journal-title":"Front. Immunol"},{"key":"2026010508050463000_2025.11.03.685859v2.28","first-page":"1","article-title":"Mast cells in inflammatory arthritis","volume":"7","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"2026010508050463000_2025.11.03.685859v2.29","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1136\/annrheumdis-2018-213418","article-title":"Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production","volume":"77","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2026010508050463000_2025.11.03.685859v2.30","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"2026010508050463000_2025.11.03.685859v2.31","doi-asserted-by":"crossref","first-page":"1275871","DOI":"10.3389\/fimmu.2023.1275871","article-title":"Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice","volume":"14","year":"2023","journal-title":"Front. Immunol"},{"key":"2026010508050463000_2025.11.03.685859v2.32","doi-asserted-by":"crossref","unstructured":"H. M. Kenney et al., Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model. Arthritis Res Ther 24, 64 (2022).","DOI":"10.1186\/s13075-022-02730-z"},{"key":"2026010508050463000_2025.11.03.685859v2.33","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"2026010508050463000_2025.11.03.685859v2.34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4742"},{"key":"2026010508050463000_2025.11.03.685859v2.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01059.x"},{"key":"2026010508050463000_2025.11.03.685859v2.36","doi-asserted-by":"crossref","unstructured":"A. Kondo , K. H. Kaestner , Emerging diverse roles of telocytes. Development 146, (2019).","DOI":"10.1242\/dev.175018"},{"key":"2026010508050463000_2025.11.03.685859v2.37","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/jcmm.16225","article-title":"Impairment in the telocyte\/CD34(+) stromal cell network in human rheumatoid arthritis synovium","volume":"25","year":"2021","journal-title":"J Cell Mol Med"},{"key":"2026010508050463000_2025.11.03.685859v2.38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37952-5"},{"key":"2026010508050463000_2025.11.03.685859v2.39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nrrheum.2018.47","article-title":"Rheumatoid arthritis: RA synovium harbours distinct fibroblast subsets","volume":"14","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2026010508050463000_2025.11.03.685859v2.40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02892-y"},{"key":"2026010508050463000_2025.11.03.685859v2.41","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000239"},{"key":"2026010508050463000_2025.11.03.685859v2.42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802224R"},{"key":"2026010508050463000_2025.11.03.685859v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0084-4"},{"key":"2026010508050463000_2025.11.03.685859v2.44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00074.2009"},{"key":"2026010508050463000_2025.11.03.685859v2.45","doi-asserted-by":"publisher","DOI":"10.1186\/ar1174"},{"key":"2026010508050463000_2025.11.03.685859v2.46","doi-asserted-by":"crossref","unstructured":"B. M. Radu et al., Calcium Signaling in Interstitial Cells: Focus on Telocytes. Int J Mol Sci 18, (2017).","DOI":"10.3390\/ijms18020397"},{"key":"2026010508050463000_2025.11.03.685859v2.47","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15749"},{"key":"2026010508050463000_2025.11.03.685859v2.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2022.03.002"},{"key":"2026010508050463000_2025.11.03.685859v2.49","unstructured":"Y. Peng et al., The Function of Efhd1+ Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis. bioRxiv v\\https:\/\/www.biorxiv.org\/content\/10.1101\/2025.11.03.685859v1, (2025)."},{"key":"2026010508050463000_2025.11.03.685859v2.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.01.018"},{"key":"2026010508050463000_2025.11.03.685859v2.51","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110883"},{"key":"2026010508050463000_2025.11.03.685859v2.52","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2103726"},{"key":"2026010508050463000_2025.11.03.685859v2.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"key":"2026010508050463000_2025.11.03.685859v2.54","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0378-1"},{"key":"2026010508050463000_2025.11.03.685859v2.55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2222-z"},{"key":"2026010508050463000_2025.11.03.685859v2.56","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes122"},{"key":"2026010508050463000_2025.11.03.685859v2.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-003-0125-3"},{"key":"2026010508050463000_2025.11.03.685859v2.58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13075-021-02438-6","article-title":"Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice","volume":"23","year":"2021","journal-title":"Arthritis Res. Ther"},{"key":"2026010508050463000_2025.11.03.685859v2.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.01.001"},{"key":"2026010508050463000_2025.11.03.685859v2.60","doi-asserted-by":"crossref","unstructured":"H. M. Kenney et al., The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate? Curr Rheumatol Rev, (2023).","DOI":"10.2174\/1573397119666230127144711"},{"key":"2026010508050463000_2025.11.03.685859v2.61","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8712-2_15"},{"key":"2026010508050463000_2025.11.03.685859v2.62","first-page":"1014","article-title":"Lymphatic vasomotion. Clin. Exp. Pharmacol","volume":"27","year":"2000","journal-title":"Physiol"},{"key":"2026010508050463000_2025.11.03.685859v2.63","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.043299"},{"key":"2026010508050463000_2025.11.03.685859v2.64","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00361.2004"},{"key":"2026010508050463000_2025.11.03.685859v2.65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01506.x"},{"key":"2026010508050463000_2025.11.03.685859v2.66","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.122861"},{"key":"2026010508050463000_2025.11.03.685859v2.67","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.097485"},{"key":"2026010508050463000_2025.11.03.685859v2.68","doi-asserted-by":"publisher","DOI":"10.1159\/000342437"},{"key":"2026010508050463000_2025.11.03.685859v2.69","doi-asserted-by":"crossref","unstructured":"K. M. Sanders , L. F. Santana , S. A. Baker , Interstitial cells of Cajal - pacemakers of the gastrointestinal tract. J. Physiol., (2023).","DOI":"10.1113\/JP284745"},{"key":"2026010508050463000_2025.11.03.685859v2.70","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.073833"},{"key":"2026010508050463000_2025.11.03.685859v2.71","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.176198"},{"key":"2026010508050463000_2025.11.03.685859v2.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.09.079"},{"key":"2026010508050463000_2025.11.03.685859v2.73","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/micc.12162","article-title":"Itching for answers: how histamine relaxes lymphatic vessels","volume":"21","year":"2014","journal-title":"Microcirculation"},{"key":"2026010508050463000_2025.11.03.685859v2.74","doi-asserted-by":"publisher","DOI":"10.1080\/10739680600556902"},{"key":"2026010508050463000_2025.11.03.685859v2.75","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3992"},{"key":"2026010508050463000_2025.11.03.685859v2.76","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jcmgh.2021.05.009","article-title":"A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes","volume":"12","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"2026010508050463000_2025.11.03.685859v2.77","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277152"},{"key":"2026010508050463000_2025.11.03.685859v2.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2016.03.002"},{"key":"2026010508050463000_2025.11.03.685859v2.79","doi-asserted-by":"crossref","unstructured":"M. Klein , M. Csobonyeiova , S. Ziaran , L. Danisovic , I. Varga , Cardiac Telocytes 16 Years on-What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine? Int J Mol Sci 22, (2021).","DOI":"10.3390\/ijms222010942"},{"key":"2026010508050463000_2025.11.03.685859v2.80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75190-7"},{"key":"2026010508050463000_2025.11.03.685859v2.81","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/art.40903","article-title":"Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis","volume":"71","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2026010508050463000_2025.11.03.685859v2.82","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.tiv.2015.08.014","article-title":"Effect of the ostreolysin A\/pleurotolysin B pore-forming complex on intracellular Ca2+ activity in the vascular smooth muscle cell line A10","volume":"29","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"2026010508050463000_2025.11.03.685859v2.83","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.455709"},{"key":"2026010508050463000_2025.11.03.685859v2.84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073766"},{"key":"2026010508050463000_2025.11.03.685859v2.85","doi-asserted-by":"crossref","first-page":"101167","DOI":"10.1016\/j.bonr.2022.101167","article-title":"A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets","volume":"16","year":"2022","journal-title":"Bone Rep"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.11.03.685859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:57:34Z","timestamp":1768471054000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.11.03.685859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":85,"URL":"https:\/\/doi.org\/10.1101\/2025.11.03.685859","relation":{},"subject":[],"published":{"date-parts":[[2025,11,5]]},"subtype":"preprint"}}