{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:21:43Z","timestamp":1787872903566,"version":"build-2784847793"},"posted":{"date-parts":[[2025,11,17]]},"group-title":"Systems Biology","reference-count":124,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["FO999902549"],"award-info":[{"award-number":["FO999902549"]}],"id":[{"id":"https:\/\/ror.org\/028jc0449","id-type":"ROR","asserted-by":"publisher"}]},{"award":["10.55776\/P36971"],"award-info":[{"award-number":["10.55776\/P36971"]}],"id":[{"id":"https:\/\/ror.org\/013tf3c58","id-type":"ROR","asserted-by":"publisher"}]},{"award":["10.55776\/PAT3564423"],"award-info":[{"award-number":["10.55776\/PAT3564423"]}],"id":[{"id":"https:\/\/ror.org\/013tf3c58","id-type":"ROR","asserted-by":"publisher"}]},{"award":["10.47379\/LS24012"],"award-info":[{"award-number":["10.47379\/LS24012"]}],"id":[{"id":"https:\/\/ror.org\/01f9mc681","id-type":"ROR","asserted-by":"publisher"}]},{"award":["906-2022"],"award-info":[{"award-number":["906-2022"]}],"id":[{"id":"https:\/\/ror.org\/04wfr2810","id-type":"ROR","asserted-by":"publisher"}]},{"award":["FRN 187814"],"award-info":[{"award-number":["FRN 187814"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"award":["ED6-190718"],"award-info":[{"award-number":["ED6-190718"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"award":["PJT-496918"],"award-info":[{"award-number":["PJT-496918"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"award":["TFRI Project #1107"],"award-info":[{"award-number":["TFRI Project #1107"]}],"id":[{"id":"https:\/\/ror.org\/00mtf6c40","id-type":"ROR","asserted-by":"publisher"}]},{"award":["HG010730"],"award-info":[{"award-number":["HG010730"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["NS099068"],"award-info":[{"award-number":["NS099068"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AI024717"],"award-info":[{"award-number":["AI024717"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["AI148276"],"award-info":[{"award-number":["AI148276"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,11,17]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                <jats:p>\n                  Pathogens deploy effector proteins to exploit host cell biology, and most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. We developed the eORFeome, a scalable functional genomics platform encompassing 3,835 effector ORFs from diverse viruses, bacteria, and parasites. High-throughput barcoded screens across NF\u03baB, apoptosis, p53, cGAS\u2013STING and MHC-I pathways revealed functions for hundreds of uncharacterized eORFs, unexpected new activities for known effectors, and distinct pathway-specific functions encoded by single ORFs. Illustrating the power of the approach, we identify HHV6A U14 as a p53 antagonist, HHV7 U21 as a dual-function STING antagonist and MHC-I antigen display inhibitor, and adenoviral 13.6K\/i-leader protein as a\n                  <jats:italic>de novo<\/jats:italic>\n                  evolved TAP inhibitor that suppresses MHC-I display. These results establish a general framework for systematic effector annotation, uncover new mechanisms of host\u2013pathogen interaction across kingdoms, and highlight pathogen effectors as a versatile toolkit for rewiring and probing human cellular pathways.\n                <\/jats:p>","DOI":"10.1101\/2025.11.17.687821","type":"posted-content","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T04:00:15Z","timestamp":1763438415000},"source":"Crossref","is-referenced-by-count":2,"title":["Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-7715","authenticated-orcid":false,"given":"Tomas","family":"Pachano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-2010","authenticated-orcid":false,"given":"Guillaume","family":"Dugied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Tribble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-378X","authenticated-orcid":false,"given":"Vincent","family":"Loubiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7436-2640","authenticated-orcid":false,"given":"Felix","family":"Rauh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeojin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-2747","authenticated-orcid":false,"given":"Alexander","family":"Schleiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-595X","authenticated-orcid":false,"given":"Benjamin","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0337-7140","authenticated-orcid":false,"given":"Eleanor A.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-4333","authenticated-orcid":false,"given":"Matthew R.","family":"Hass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-2220","authenticated-orcid":false,"given":"Leah C.","family":"Kottayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-9122","authenticated-orcid":false,"given":"Matthew T.","family":"Weirauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-1207","authenticated-orcid":false,"given":"Juan I.","family":"Fuxman Bass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-2001","authenticated-orcid":false,"given":"Hayley J.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-3704","authenticated-orcid":false,"given":"Alexander W.","family":"Ensminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-6746","authenticated-orcid":false,"given":"Pascal","family":"Falter-Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-2104","authenticated-orcid":false,"given":"Daniel","family":"Schramek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-0841","authenticated-orcid":false,"given":"Alexander","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-1761","authenticated-orcid":false,"given":"Mikko","family":"Taipale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025112001250500000_2025.11.17.687821v1.1","doi-asserted-by":"publisher","DOI":"10.3390\/life11090988"},{"key":"2025112001250500000_2025.11.17.687821v1.2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-100520-011851"},{"key":"2025112001250500000_2025.11.17.687821v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.06.005"},{"key":"2025112001250500000_2025.11.17.687821v1.4","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001269"},{"key":"2025112001250500000_2025.11.17.687821v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.17"},{"key":"2025112001250500000_2025.11.17.687821v1.6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1112.050997"},{"key":"2025112001250500000_2025.11.17.687821v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10423"},{"key":"2025112001250500000_2025.11.17.687821v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04332-2"},{"key":"2025112001250500000_2025.11.17.687821v1.9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1154"},{"key":"2025112001250500000_2025.11.17.687821v1.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000376"},{"key":"2025112001250500000_2025.11.17.687821v1.11","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00537-10"},{"key":"2025112001250500000_2025.11.17.687821v1.12","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.00126"},{"key":"2025112001250500000_2025.11.17.687821v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-025-00038-x"},{"key":"2025112001250500000_2025.11.17.687821v1.14","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0210"},{"key":"2025112001250500000_2025.11.17.687821v1.15","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe9403"},{"key":"2025112001250500000_2025.11.17.687821v1.16","doi-asserted-by":"publisher","DOI":"10.3390\/v13030388"},{"key":"2025112001250500000_2025.11.17.687821v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.08.026"},{"key":"2025112001250500000_2025.11.17.687821v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07809-y"},{"key":"2025112001250500000_2025.11.17.687821v1.19","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.608860"},{"key":"2025112001250500000_2025.11.17.687821v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature06247"},{"key":"2025112001250500000_2025.11.17.687821v1.21","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0064-6"},{"key":"2025112001250500000_2025.11.17.687821v1.22","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj7965"},{"key":"2025112001250500000_2025.11.17.687821v1.23","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5200"},{"key":"2025112001250500000_2025.11.17.687821v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00700-7"},{"key":"2025112001250500000_2025.11.17.687821v1.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03493-4"},{"key":"2025112001250500000_2025.11.17.687821v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0484-5"},{"key":"2025112001250500000_2025.11.17.687821v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/nature11289"},{"key":"2025112001250500000_2025.11.17.687821v1.28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49894"},{"key":"2025112001250500000_2025.11.17.687821v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.08.010"},{"key":"2025112001250500000_2025.11.17.687821v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/nature10719"},{"key":"2025112001250500000_2025.11.17.687821v1.31","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR118.000800"},{"key":"2025112001250500000_2025.11.17.687821v1.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2286-9"},{"key":"2025112001250500000_2025.11.17.687821v1.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012010"},{"key":"2025112001250500000_2025.11.17.687821v1.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.11.026"},{"key":"2025112001250500000_2025.11.17.687821v1.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2010.01452.x"},{"key":"2025112001250500000_2025.11.17.687821v1.36","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20167381"},{"key":"2025112001250500000_2025.11.17.687821v1.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603866103"},{"key":"2025112001250500000_2025.11.17.687821v1.38","doi-asserted-by":"publisher","DOI":"10.1101\/2023.09.25.559292"},{"key":"2025112001250500000_2025.11.17.687821v1.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.09.011"},{"key":"2025112001250500000_2025.11.17.687821v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2539"},{"key":"2025112001250500000_2025.11.17.687821v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2010.04.001"},{"key":"2025112001250500000_2025.11.17.687821v1.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.034"},{"key":"2025112001250500000_2025.11.17.687821v1.43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005484"},{"key":"2025112001250500000_2025.11.17.687821v1.44","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.748404"},{"key":"2025112001250500000_2025.11.17.687821v1.45","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00010-17"},{"key":"2025112001250500000_2025.11.17.687821v1.46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02337-10"},{"key":"2025112001250500000_2025.11.17.687821v1.47","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4189"},{"key":"2025112001250500000_2025.11.17.687821v1.48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4436"},{"key":"2025112001250500000_2025.11.17.687821v1.49","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0554-4"},{"key":"2025112001250500000_2025.11.17.687821v1.50","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00447-11"},{"key":"2025112001250500000_2025.11.17.687821v1.51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07568.x"},{"key":"2025112001250500000_2025.11.17.687821v1.52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001231"},{"key":"2025112001250500000_2025.11.17.687821v1.53","doi-asserted-by":"publisher","DOI":"10.3390\/v14020391"},{"key":"2025112001250500000_2025.11.17.687821v1.54","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06005-11"},{"key":"2025112001250500000_2025.11.17.687821v1.55","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.441-449.2005"},{"key":"2025112001250500000_2025.11.17.687821v1.56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306198200"},{"key":"2025112001250500000_2025.11.17.687821v1.57","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7094"},{"key":"2025112001250500000_2025.11.17.687821v1.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.12.023"},{"key":"2025112001250500000_2025.11.17.687821v1.59","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132641"},{"key":"2025112001250500000_2025.11.17.687821v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01773-0"},{"key":"2025112001250500000_2025.11.17.687821v1.61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt412"},{"key":"2025112001250500000_2025.11.17.687821v1.62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620973114"},{"key":"2025112001250500000_2025.11.17.687821v1.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.043"},{"key":"2025112001250500000_2025.11.17.687821v1.64","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101721-032910"},{"key":"2025112001250500000_2025.11.17.687821v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0341-y"},{"key":"2025112001250500000_2025.11.17.687821v1.66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636568"},{"key":"2025112001250500000_2025.11.17.687821v1.67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002481117"},{"key":"2025112001250500000_2025.11.17.687821v1.68","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60821"},{"key":"2025112001250500000_2025.11.17.687821v1.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7742"},{"key":"2025112001250500000_2025.11.17.687821v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202953"},{"key":"2025112001250500000_2025.11.17.687821v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.007"},{"key":"2025112001250500000_2025.11.17.687821v1.72","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12079"},{"key":"2025112001250500000_2025.11.17.687821v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.297"},{"key":"2025112001250500000_2025.11.17.687821v1.74","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.13037-13046.2005"},{"key":"2025112001250500000_2025.11.17.687821v1.75","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1456306"},{"key":"2025112001250500000_2025.11.17.687821v1.76","first-page":"1103","article-title":"Cooperation of SV40 large T antigen and the cellular protein p53 in maintenance of cell transformation","volume":"4","year":"1989","journal-title":"Oncogene"},{"key":"2025112001250500000_2025.11.17.687821v1.77","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174294"},{"key":"2025112001250500000_2025.11.17.687821v1.78","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3646"},{"key":"2025112001250500000_2025.11.17.687821v1.79","doi-asserted-by":"publisher","DOI":"10.1038\/nature05541"},{"key":"2025112001250500000_2025.11.17.687821v1.80","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0928-6"},{"key":"2025112001250500000_2025.11.17.687821v1.81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007691"},{"key":"2025112001250500000_2025.11.17.687821v1.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111949"},{"key":"2025112001250500000_2025.11.17.687821v1.83","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7673-7681.2005"},{"key":"2025112001250500000_2025.11.17.687821v1.84","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.05.006"},{"key":"2025112001250500000_2025.11.17.687821v1.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.047"},{"key":"2025112001250500000_2025.11.17.687821v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0705-y"},{"key":"2025112001250500000_2025.11.17.687821v1.87","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864898"},{"key":"2025112001250500000_2025.11.17.687821v1.88","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-07-0363"},{"key":"2025112001250500000_2025.11.17.687821v1.89","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.24.12347-12358.2001"},{"key":"2025112001250500000_2025.11.17.687821v1.90","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9219.2003.0137.x"},{"key":"2025112001250500000_2025.11.17.687821v1.91","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81054-5"},{"key":"2025112001250500000_2025.11.17.687821v1.92","doi-asserted-by":"publisher","DOI":"10.1038\/384432a0"},{"key":"2025112001250500000_2025.11.17.687821v1.93","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200111010"},{"key":"2025112001250500000_2025.11.17.687821v1.94","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.45.1.185-191.1983"},{"key":"2025112001250500000_2025.11.17.687821v1.95","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00747-y"},{"key":"2025112001250500000_2025.11.17.687821v1.96","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80079-9"},{"key":"2025112001250500000_2025.11.17.687821v1.97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2516676122"},{"key":"2025112001250500000_2025.11.17.687821v1.98","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7199"},{"key":"2025112001250500000_2025.11.17.687821v1.99","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01890-z"},{"key":"2025112001250500000_2025.11.17.687821v1.100","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.57.3.848-856.1986"},{"key":"2025112001250500000_2025.11.17.687821v1.101","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13682"},{"key":"2025112001250500000_2025.11.17.687821v1.102","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2017.08.032"},{"key":"2025112001250500000_2025.11.17.687821v1.103","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"2025112001250500000_2025.11.17.687821v1.104","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2025112001250500000_2025.11.17.687821v1.105","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae268"},{"key":"2025112001250500000_2025.11.17.687821v1.106","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3988"},{"key":"2025112001250500000_2025.11.17.687821v1.107","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-0850-8"},{"key":"2025112001250500000_2025.11.17.687821v1.108","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.02.005"},{"key":"2025112001250500000_2025.11.17.687821v1.109","doi-asserted-by":"publisher","DOI":"10.1089\/10430340150503984"},{"key":"2025112001250500000_2025.11.17.687821v1.110","doi-asserted-by":"publisher","DOI":"10.1038\/nature11288"},{"key":"2025112001250500000_2025.11.17.687821v1.111","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201400612"},{"key":"2025112001250500000_2025.11.17.687821v1.112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009033"},{"key":"2025112001250500000_2025.11.17.687821v1.113","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041912"},{"key":"2025112001250500000_2025.11.17.687821v1.114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002056"},{"key":"2025112001250500000_2025.11.17.687821v1.115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215278110"},{"key":"2025112001250500000_2025.11.17.687821v1.116","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01729-14"},{"key":"2025112001250500000_2025.11.17.687821v1.117","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07224-3"},{"key":"2025112001250500000_2025.11.17.687821v1.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.12.008"},{"key":"2025112001250500000_2025.11.17.687821v1.119","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"2025112001250500000_2025.11.17.687821v1.120","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"2025112001250500000_2025.11.17.687821v1.121","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"2025112001250500000_2025.11.17.687821v1.122","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4792"},{"key":"2025112001250500000_2025.11.17.687821v1.123","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.05.015"},{"key":"2025112001250500000_2025.11.17.687821v1.124","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45920-w"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.11.17.687821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:02:49Z","timestamp":1768471369000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.11.17.687821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":124,"URL":"https:\/\/doi.org\/10.1101\/2025.11.17.687821","relation":{},"subject":[],"published":{"date-parts":[[2025,11,17]]},"subtype":"preprint"}}