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We created the first platform for high-resolution continuous behavioral tracking of a vertebrate animal across natural lifespan from adolescence to death\u2014here, of the African killifish. This behavioral screen revealed that animals follow distinct individual aging trajectories. The behaviors of long-lived animals differed markedly from those of short-lived animals, even relatively early in life, and were linked to organ-specific transcriptomic shifts. Machine learning models accurately predicted age and even forecasted an individual\u2019s future lifespan, given only behavior at a young age. Finally, we found that animals progressed through adulthood in a sequence of stable and stereotyped behavioral stages with abrupt transitions suggesting a novel structure for the architecture of vertebrate aging.<\/jats:p>","DOI":"10.1101\/2025.11.21.688112","type":"posted-content","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:45:12Z","timestamp":1763977512000},"source":"Crossref","is-referenced-by-count":1,"title":["Life-long behavioral screen reveals an architecture of vertebrate aging"],"prefix":"10.64898","author":[{"given":"Claire N.","family":"Bedbrook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi D.","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Linderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Brunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Deisseroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2025112600150991000_2025.11.21.688112v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"2025112600150991000_2025.11.21.688112v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90201-4"},{"key":"2025112600150991000_2025.11.21.688112v1.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162493"},{"key":"2025112600150991000_2025.11.21.688112v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.031"},{"key":"2025112600150991000_2025.11.21.688112v1.5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1126\/science.ado7604","article-title":"Axis formation in annual killifish: Nodal and \u03b2-catenin regulate morphogenesis without Huluwa prepatterning","volume":"384","year":"2024","journal-title":"Science"},{"key":"2025112600150991000_2025.11.21.688112v1.6","doi-asserted-by":"crossref","unstructured":"J. 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