{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:45:52Z","timestamp":1791477952066,"version":"4.3.4"},"posted":{"date-parts":[[2025,12,3]]},"group-title":"Immunology","reference-count":107,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["1R15AI178461-01"],"award-info":[{"award-number":["1R15AI178461-01"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Alveolar macrophages (AMs) serve as a first line of defense against respiratory pathogens, including\n                  <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                  , the primary causative agent of cryptococcosis, a deadly pulmonary mycosis which commonly afflicts immunocompromised individuals. While these innate immune cells are thought to play a pivotal role in controlling the outcome of\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  infections, this critical host-pathogen interaction is more commonly studied\n                  <jats:italic>in vitro<\/jats:italic>\n                  using bone marrow-derived macrophages (BMDM) or immortalized macrophage cell lines that differ in ontogeny and phenotype from AMs. In this work, we characterized fetal liver-derived alveolar-like macrophages (FLAMs) as an alternate model to study the earliest stages of\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  infection. Here, we show that the FLAM steady state transcriptome is more similar to primary AMs than peritoneal macrophages and the macrophage cell lines, RAW264.7 and J774, and that FLAMs exhibit distinct transcriptional responses to IFN\u03b3 stimulation and\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  infection compared to J774 cells. Specifically, transcriptome profiling and gene ontology analysis indicate that\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  infection of FLAMs, but not J774 cells, increases the expression of canonical glycolytic genes, including\n                  <jats:italic>Slc2a1, Pgk1, and Ldha<\/jats:italic>\n                  , which is accompanied by a metabolic shift favoring glycolysis. Furthermore, activation or inhibition of hypoxia inducible factor 1 (HIF1) activity utilizing dimethyloxalylglycine (DMOG) and echinomycin, respectively, indicates that the expression of select glycolytic genes in\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  -infected FLAMs is HIF1-dependent. Collectively, our results suggest that FLAMs serve as an appropriate tool for modeling AM:\n                  <jats:italic>C. neoformans<\/jats:italic>\n                  interactions and investigating the effects of this pathogen on host AM immunometabolism.\n                <\/jats:p>","DOI":"10.1101\/2025.11.28.690224","type":"posted-content","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:06:36Z","timestamp":1764957996000},"source":"Crossref","is-referenced-by-count":1,"title":["Intracellular\n                  <i>C. neoformans<\/i>\n                  infection stimulates increased glycolytic activity in fetal liver-derived alveolar-like macrophages"],"prefix":"10.64898","author":[{"given":"Derek A.","family":"Wiggins","sequence":"first","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh B.","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"England","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily N.","family":"Callison","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedra H.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine A.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan E.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2408-6502","authenticated-orcid":false,"given":"Kayla N.","family":"Conner-Halim","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, Michigan State University, Lansing, MI 48910"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Olive","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"McClelland","sequence":"additional","affiliation":[{"name":"Wood College of Osteopathic Medicine, Marian University, Indianapolis, IN 46222"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel N.","family":"Leander","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Seipelt-Thiemann","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-0885","authenticated-orcid":false,"given":"David E.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026010104573535000_2025.11.28.690224v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(22)00499-6"},{"key":"2026010104573535000_2025.11.28.690224v1.2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.515"},{"key":"2026010104573535000_2025.11.28.690224v1.3","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00454-09"},{"key":"2026010104573535000_2025.11.28.690224v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.11.001"},{"key":"2026010104573535000_2025.11.28.690224v1.5","doi-asserted-by":"crossref","unstructured":"Melhem, M. S. C. , Leite Junior, D. P. , Takahashi, J. P. F. , Macioni, M. B. , Oliveira, L. , de Araujo, L. S. , Fava, W. S. , Bonfietti, L. X. , Paniago, A. M. M. , Venturini, J. , and Espinel-Ingroff, A. (2024) Antifungal Resistance in Cryptococcal Infections. Pathogens 13","DOI":"10.3390\/pathogens13020128"},{"key":"2026010104573535000_2025.11.28.690224v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00511-0"},{"key":"2026010104573535000_2025.11.28.690224v1.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"2026010104573535000_2025.11.28.690224v1.8","doi-asserted-by":"crossref","unstructured":"Coelho, C. , Souza, A. C. , Derengowski, L. D. , de Leon-Rodriguez, C. , Wang, B. , Leon-Rivera, R. , Bocca, A. L. , Goncalves, T. , and Casadevall, A. (2015) Macrophage Mitochondrial and Stress Response to Ingestion of Cryptococcus neoformans. Journal of immunology","DOI":"10.4049\/jimmunol.1402350"},{"key":"2026010104573535000_2025.11.28.690224v1.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233818"},{"key":"2026010104573535000_2025.11.28.690224v1.10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.738187"},{"key":"2026010104573535000_2025.11.28.690224v1.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052702799"},{"key":"2026010104573535000_2025.11.28.690224v1.12","doi-asserted-by":"crossref","unstructured":"Zhang, L. , Zhang, K. , Li, H. , Coelho, C. , de Souza Goncalves, D. , Fu, M. S. , Li, X. , Nakayasu, E. S. , Kim, Y. M. , Liao, W. , Pan, W. , and Casadevall, A. (2021) Cryptococcus neoformans-Infected Macrophages Release Proinflammatory Extracellular Vesicles: Insight into Their Components by Multi-omics. mBio 12","DOI":"10.1128\/mBio.00279-21"},{"key":"2026010104573535000_2025.11.28.690224v1.13","doi-asserted-by":"crossref","unstructured":"Kalem, M. C. , Humby, M. S. , Wohlfert, E. A. , Jacobs, A. , and Panepinto, J. C. (2021) Cryptococcus neoformans Coinfection Dampens the TNF-alpha Response in HIV-1-Infected Human THP-1 Macrophages. mSphere 6","DOI":"10.1128\/mSphere.00213-21"},{"key":"2026010104573535000_2025.11.28.690224v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.024"},{"key":"2026010104573535000_2025.11.28.690224v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3324"},{"key":"2026010104573535000_2025.11.28.690224v1.16","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13154"},{"key":"2026010104573535000_2025.11.28.690224v1.17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131199"},{"key":"2026010104573535000_2025.11.28.690224v1.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.007"},{"key":"2026010104573535000_2025.11.28.690224v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3005"},{"key":"2026010104573535000_2025.11.28.690224v1.20","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0244OC"},{"key":"2026010104573535000_2025.11.28.690224v1.21","doi-asserted-by":"crossref","first-page":"166488","DOI":"10.1016\/j.bbadis.2022.166488","article-title":"Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide","volume":"1868","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2026010104573535000_2025.11.28.690224v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00218-7"},{"key":"2026010104573535000_2025.11.28.690224v1.23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.090601.113847"},{"key":"2026010104573535000_2025.11.28.690224v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00480-w"},{"key":"2026010104573535000_2025.11.28.690224v1.25","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-35"},{"key":"2026010104573535000_2025.11.28.690224v1.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.006"},{"key":"2026010104573535000_2025.11.28.690224v1.27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0295312"},{"key":"2026010104573535000_2025.11.28.690224v1.28","doi-asserted-by":"crossref","unstructured":"Busch, C. J. , Favret, J. , Geirsdottir, L. , Molawi, K. , and Sieweke, M. H . (2019) Isolation and Long-term Cultivation of Mouse Alveolar Macrophages. Bio Protoc 9","DOI":"10.21769\/BioProtoc.3302"},{"key":"2026010104573535000_2025.11.28.690224v1.29","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2200011"},{"key":"2026010104573535000_2025.11.28.690224v1.30","doi-asserted-by":"publisher","DOI":"10.1038\/ni1008-1091"},{"key":"2026010104573535000_2025.11.28.690224v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01146-w"},{"key":"2026010104573535000_2025.11.28.690224v1.32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103455"},{"key":"2026010104573535000_2025.11.28.690224v1.33","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090634"},{"key":"2026010104573535000_2025.11.28.690224v1.34","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00935-15"},{"key":"2026010104573535000_2025.11.28.690224v1.35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111302200"},{"key":"2026010104573535000_2025.11.28.690224v1.36","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2519"},{"key":"2026010104573535000_2025.11.28.690224v1.37","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4225-4237.2000"},{"key":"2026010104573535000_2025.11.28.690224v1.38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-pathol-012513-104653","article-title":"The intracellular life of Cryptococcus neoformans","volume":"9","year":"2014","journal-title":"Annual review of pathology"},{"key":"2026010104573535000_2025.11.28.690224v1.39","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00587-07"},{"key":"2026010104573535000_2025.11.28.690224v1.40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006680"},{"key":"2026010104573535000_2025.11.28.690224v1.41","doi-asserted-by":"crossref","unstructured":"Santiago-Tirado, F. H. , Onken, M. D. , Cooper, J. A. , Klein, R. S. , and Doering, T. L . (2017) Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen. mBio 8","DOI":"10.1128\/mBio.02183-16"},{"key":"2026010104573535000_2025.11.28.690224v1.42","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cub.2006.09.061","article-title":"Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages","volume":"16","year":"2006","journal-title":"Current biology: CB"},{"key":"2026010104573535000_2025.11.28.690224v1.43","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cub.2006.09.032","article-title":"Expulsion of live pathogenic yeast by macrophages","volume":"16","year":"2006","journal-title":"Current biology: CB"},{"key":"2026010104573535000_2025.11.28.690224v1.44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-16"},{"key":"2026010104573535000_2025.11.28.690224v1.45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-8-15"},{"key":"2026010104573535000_2025.11.28.690224v1.46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801118"},{"key":"2026010104573535000_2025.11.28.690224v1.47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84431"},{"key":"2026010104573535000_2025.11.28.690224v1.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.09.005"},{"key":"2026010104573535000_2025.11.28.690224v1.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218599110"},{"key":"2026010104573535000_2025.11.28.690224v1.50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.3318"},{"key":"2026010104573535000_2025.11.28.690224v1.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005408"},{"key":"2026010104573535000_2025.11.28.690224v1.52","doi-asserted-by":"crossref","first-page":"114682","DOI":"10.1016\/j.celrep.2024.114682","article-title":"MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation","volume":"43","year":"2024","journal-title":"Cell Rep"},{"key":"2026010104573535000_2025.11.28.690224v1.53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915333117"},{"key":"2026010104573535000_2025.11.28.690224v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/nsb936"},{"key":"2026010104573535000_2025.11.28.690224v1.55","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001650"},{"key":"2026010104573535000_2025.11.28.690224v1.56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000864R"},{"key":"2026010104573535000_2025.11.28.690224v1.57","doi-asserted-by":"crossref","unstructured":"Zafar, A. , Ng, H. P. , Chan, E. R. , Dunwoodie, S. L. , and Mahabeleshwar, G. H . (2023) Myeloid-CITED2 Deficiency Exacerbates Diet-Induced Obesity and Pro-Inflammatory Macrophage Response. Cells 12","DOI":"10.3390\/cells12172136"},{"key":"2026010104573535000_2025.11.28.690224v1.58","doi-asserted-by":"crossref","first-page":"e21833","DOI":"10.1096\/fj.202100792R","article-title":"CITED2 inhibits STAT1-IRF1 signaling and atherogenesis","volume":"35","year":"2021","journal-title":"FASEB J"},{"key":"2026010104573535000_2025.11.28.690224v1.59","doi-asserted-by":"crossref","unstructured":"Subramani, A. , Hite, M. E. L. , Garcia, S. , Maxwell, J. , Kondee, H. , Millican, G. E. , McClelland, E. E. , Seipelt-Thiemann, R. L. , and Nelson, D. E . (2023) Regulation of macrophage IFNgamma-stimulated gene expression by the transcriptional coregulator CITED1. Journal of cell science 136","DOI":"10.1242\/jcs.260529"},{"key":"2026010104573535000_2025.11.28.690224v1.60","first-page":"1833","article-title":"Hypoxia-inducible factor 1 alpha upregulates the expression of inducible nitric oxide synthase gene in pulmonary arteries of hyposic rat","volume":"115","year":"2002","journal-title":"Chin Med J (Engl"},{"key":"2026010104573535000_2025.11.28.690224v1.61","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.3.319"},{"key":"2026010104573535000_2025.11.28.690224v1.62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.12236"},{"key":"2026010104573535000_2025.11.28.690224v1.63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23865"},{"key":"2026010104573535000_2025.11.28.690224v1.64","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/iai.32.3.975-978.1981","article-title":"Role of macrophages in resistance of mice to experimental cryptococcosis","volume":"32","year":"1981","journal-title":"Infection and immunity"},{"key":"2026010104573535000_2025.11.28.690224v1.65","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.5.1222"},{"key":"2026010104573535000_2025.11.28.690224v1.66","doi-asserted-by":"crossref","first-page":"103258","DOI":"10.1016\/j.fgb.2019.103258","article-title":"Reduced phagocytosis and killing of Cryptococcus neoformans biofilm-derived cells by J774.16 macrophages is associated with fungal capsular production and surface modification","volume":"132","year":"2019","journal-title":"Fungal Genet Biol"},{"key":"2026010104573535000_2025.11.28.690224v1.67","doi-asserted-by":"crossref","unstructured":"Alanio, A. , Desnos-Ollivier, M. , and Dromer, F . (2011) Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in humans. mBio 2","DOI":"10.1128\/mBio.00158-11"},{"key":"2026010104573535000_2025.11.28.690224v1.68","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-0716-3722-7_11","article-title":"Assessing Phagocytosis of Cryptococcus neoformans Cells in Human Monocytes or the J774 Murine Macrophage Cell Line","volume":"2775","year":"2024","journal-title":"Methods in molecular biology"},{"key":"2026010104573535000_2025.11.28.690224v1.69","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1788-1796.2005"},{"key":"2026010104573535000_2025.11.28.690224v1.70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803504"},{"key":"2026010104573535000_2025.11.28.690224v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80085-0"},{"key":"2026010104573535000_2025.11.28.690224v1.72","doi-asserted-by":"crossref","unstructured":"Huang, S. , Zhu, B. , Cheon, I. S. , Goplen, N. P. , Jiang, L. , Zhang, R. , Peebles, R. S. , Mack, M. , Kaplan, M. H. , Limper, A. H. , and Sun, J . (2019) PPAR-gamma in Macrophages Limits Pulmonary Inflammation and Promotes Host Recovery following Respiratory Viral Infection. J Virol 93","DOI":"10.1128\/JVI.00030-19"},{"key":"2026010104573535000_2025.11.28.690224v1.73","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12964-023-01256-4","article-title":"Regulation of phosphoglycerate kinase 1 and its critical role in cancer","volume":"21","year":"2023","journal-title":"Cell Commun Signal"},{"key":"2026010104573535000_2025.11.28.690224v1.74","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41467-023-36651-5","article-title":"mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs","volume":"14","year":"2023","journal-title":"Nature communications"},{"key":"2026010104573535000_2025.11.28.690224v1.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.02.009"},{"key":"2026010104573535000_2025.11.28.690224v1.76","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9029327"},{"key":"2026010104573535000_2025.11.28.690224v1.77","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1235"},{"key":"2026010104573535000_2025.11.28.690224v1.78","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0352-y"},{"key":"2026010104573535000_2025.11.28.690224v1.79","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90625.2008"},{"key":"2026010104573535000_2025.11.28.690224v1.80","doi-asserted-by":"crossref","unstructured":"Woods, P. S. , Kimmig, L. M. , Sun, K. A. , Meliton, A. Y. , Shamaa, O. R. , Tian, Y. , Cetin-Atalay, R. , Sharp, W. W. , Hamanaka, R. B. , and Mutlu, G. M . (2022) HIF-1alpha induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife 11","DOI":"10.7554\/eLife.77457"},{"key":"2026010104573535000_2025.11.28.690224v1.81","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00326"},{"key":"2026010104573535000_2025.11.28.690224v1.82","first-page":"628","article-title":"Metabolic reprogramming of macrophages and its involvement in inflammatory diseases","volume":"20","year":"2021","journal-title":"EXCLI J"},{"key":"2026010104573535000_2025.11.28.690224v1.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.12.010"},{"key":"2026010104573535000_2025.11.28.690224v1.84","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E02-12-0791"},{"key":"2026010104573535000_2025.11.28.690224v1.85","doi-asserted-by":"publisher","DOI":"10.1038\/nature06905"},{"key":"2026010104573535000_2025.11.28.690224v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0128-5"},{"key":"2026010104573535000_2025.11.28.690224v1.87","doi-asserted-by":"crossref","unstructured":"Kim, G. D. , Das, R. , Rao, X. , Zhong, J. , Deiuliis, J. A. , Ramirez-Bergeron, D. L. , Rajagopalan, S. , and Mahabeleshwar, G. H . (2018) CITED2 Restrains Proinflammatory Macrophage Activation and Response. Molecular and cellular biology 38","DOI":"10.1128\/MCB.00452-17"},{"key":"2026010104573535000_2025.11.28.690224v1.88","doi-asserted-by":"crossref","first-page":"13693","DOI":"10.1021\/acs.jmedchem.1c01043","article-title":"Potent Inhibition of HIF1alpha and p300 Interaction by a Constrained Peptide Derived from CITED2","volume":"64","year":"2021","journal-title":"J Med Chem"},{"key":"2026010104573535000_2025.11.28.690224v1.89","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026010104573535000_2025.11.28.690224v1.90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1113"},{"key":"2026010104573535000_2025.11.28.690224v1.91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002342"},{"key":"2026010104573535000_2025.11.28.690224v1.92","unstructured":"Gruening, B. A. (2016) galaxytools. 07.2016 Ed., Zenodo"},{"key":"2026010104573535000_2025.11.28.690224v1.93","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"2026010104573535000_2025.11.28.690224v1.94","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2444-8_24"},{"key":"2026010104573535000_2025.11.28.690224v1.95","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2450"},{"key":"2026010104573535000_2025.11.28.690224v1.96","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"2026010104573535000_2025.11.28.690224v1.97","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"2026010104573535000_2025.11.28.690224v1.98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"2026010104573535000_2025.11.28.690224v1.99","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"2026010104573535000_2025.11.28.690224v1.100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157022"},{"key":"2026010104573535000_2025.11.28.690224v1.101","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2419"},{"key":"2026010104573535000_2025.11.28.690224v1.102","doi-asserted-by":"crossref","unstructured":"Baldarelli, R. M. , Smith, C. L. , Ringwald, M. , Richardson, J. E. , Bult, C. J. , and Mouse Genome Informatics, G. (2024) Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse. Genetics 227","DOI":"10.1093\/genetics\/iyae031"},{"key":"2026010104573535000_2025.11.28.690224v1.103","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1083"},{"key":"2026010104573535000_2025.11.28.690224v1.104","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2300107"},{"key":"2026010104573535000_2025.11.28.690224v1.105","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"2026010104573535000_2025.11.28.690224v1.106","unstructured":"Davis, A. E. (2025) Modeling Asymmetric Cell Division of Pathogenic Yeast within Host Macrophages for Comparison to Fluorescence Confocal Microscopy Data. Middle Tennessee State University"},{"key":"2026010104573535000_2025.11.28.690224v1.107","doi-asserted-by":"publisher","DOI":"10.1177\/0049124104268644"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/2025.11.28.690224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:07:28Z","timestamp":1768471648000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.11.28.690224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":107,"URL":"https:\/\/doi.org\/10.1101\/2025.11.28.690224","relation":{},"subject":[],"published":{"date-parts":[[2025,12,3]]},"subtype":"preprint"}}