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The average size of conserved fragments could be estimated at 27 and 8 c<jats:sc>m<\/jats:sc> with humans and mice, respectively. The position of evolutionary breakpoints often correspond with human chromosome sites known to be vulnerable to rearrangement in neoplasia. Furthermore, 75 microsatellite markers, 30 of which were isolated from gene-containing bacterial artificial chromosomes (BACs), were added to the previous goat genetic map, achieving 88% genome coverage. Finally, 124 microsatellites were cytogenetically mapped, which made it possible to physically anchor and orient all the linkage groups. We believe that this comprehensive map will speed up positional cloning projects in domestic ruminants and clarify some aspects of mammalian chromosomal evolution.<\/jats:p><jats:p>[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"G40978\" ext-link-type=\"gen\" xlink:type=\"simple\">G40978<\/jats:ext-link>\u2013<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"G41020\" ext-link-type=\"gen\" xlink:type=\"simple\">G41020<\/jats:ext-link>,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF083170\" ext-link-type=\"gen\" xlink:type=\"simple\">AF083170<\/jats:ext-link>\u2013<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF083184\" ext-link-type=\"gen\" xlink:type=\"simple\">AF083184<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF088286\" ext-link-type=\"gen\" xlink:type=\"simple\">AF088286<\/jats:ext-link>, AF08287, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF083401\" ext-link-type=\"gen\" xlink:type=\"simple\">AF083401<\/jats:ext-link>\u2013<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF083406\" ext-link-type=\"gen\" xlink:type=\"simple\">AF083406<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF082884\" ext-link-type=\"gen\" xlink:type=\"simple\">AF082884<\/jats:ext-link>, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF082885\" ext-link-type=\"gen\" xlink:type=\"simple\">AF082885<\/jats:ext-link>.]<\/jats:p>","DOI":"10.1101\/gr.8.9.901","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:33:52Z","timestamp":1493771632000},"page":"901-915","source":"Crossref","is-referenced-by-count":102,"title":["Comparative Gene Mapping: A Fine-Scale Survey of Chromosome Rearrangements between Ruminants and Humans"],"prefix":"10.1101","volume":"8","author":[{"given":"Laurent","family":"Schibler","sequence":"first","affiliation":[]},{"given":"Daniel","family":"Vaiman","sequence":"additional","affiliation":[]},{"given":"Anne","family":"Oustry","sequence":"additional","affiliation":[]},{"given":"Corinne","family":"Giraud-Delville","sequence":"additional","affiliation":[]},{"given":"Edmond P.","family":"Cribiu","sequence":"additional","affiliation":[]}],"member":"246","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"2021111810281981000_8.9.901.1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(95)80077-Y"},{"key":"2021111810281981000_8.9.901.2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900340"},{"key":"2021111810281981000_8.9.901.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00484229"},{"key":"2021111810281981000_8.9.901.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292023"},{"key":"2021111810281981000_8.9.901.5","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4998"},{"key":"2021111810281981000_8.9.901.6","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.9986"},{"key":"2021111810281981000_8.9.901.7","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.12.1123"},{"key":"2021111810281981000_8.9.901.8","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900034"},{"key":"2021111810281981000_8.9.901.9","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.7.580"},{"key":"2021111810281981000_8.9.901.10","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900086"},{"key":"2021111810281981000_8.9.901.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.3019"},{"key":"2021111810281981000_8.9.901.12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/genetics\/140.2.703","article-title":"An autosomal genetic linkage map of the sheep genome.","volume":"140","author":"Crawford","year":"1995","journal-title":"Genetics"},{"key":"2021111810281981000_8.9.901.13","first-page":"195","article-title":"Inversions in evolution of man and closely related species.","volume":"29","author":"Dutrillaux","year":"1986","journal-title":"Annu. 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