{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:06Z","timestamp":1791356826508,"version":"4.3.1"},"reference-count":224,"publisher":"Cold Spring Harbor Laboratory","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Perspect Biol"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1101\/cshperspect.a021899","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T19:23:53Z","timestamp":1464809033000},"page":"a021899","source":"Crossref","is-referenced-by-count":513,"title":["Bone Morphogenetic Proteins"],"prefix":"10.1101","volume":"8","author":[{"given":"Takenobu","family":"Katagiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Watabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"2018091410583838000_8.6.a021899.1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3680"},{"key":"2018091410583838000_8.6.a021899.2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0273"},{"key":"2018091410583838000_8.6.a021899.3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm453"},{"key":"2018091410583838000_8.6.a021899.4","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01125"},{"key":"2018091410583838000_8.6.a021899.5","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0005"},{"key":"2018091410583838000_8.6.a021899.6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503511200"},{"key":"2018091410583838000_8.6.a021899.7","doi-asserted-by":"publisher","DOI":"10.1038\/ng1777"},{"key":"2018091410583838000_8.6.a021899.8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199812)213:4<398::AID-AJA5>3.0.CO;2-T"},{"key":"2018091410583838000_8.6.a021899.9","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21509"},{"key":"2018091410583838000_8.6.a021899.10","doi-asserted-by":"publisher","DOI":"10.1021\/jm300985d"},{"key":"2018091410583838000_8.6.a021899.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0751-1"},{"key":"2018091410583838000_8.6.a021899.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.07.018"},{"key":"2018091410583838000_8.6.a021899.13","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2965"},{"key":"2018091410583838000_8.6.a021899.14","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0207com"},{"key":"2018091410583838000_8.6.a021899.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.10.003"},{"key":"2018091410583838000_8.6.a021899.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.12.004"},{"key":"2018091410583838000_8.6.a021899.17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503328200"},{"key":"2018091410583838000_8.6.a021899.18","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1455"},{"key":"2018091410583838000_8.6.a021899.19","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.400"},{"key":"2018091410583838000_8.6.a021899.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.04.030"},{"key":"2018091410583838000_8.6.a021899.21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq396"},{"key":"2018091410583838000_8.6.a021899.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9843"},{"key":"2018091410583838000_8.6.a021899.23","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.1.295"},{"key":"2018091410583838000_8.6.a021899.24","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.172"},{"key":"2018091410583838000_8.6.a021899.25","first-page":"1544","article-title":"Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)","volume":"85-A","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"2018091410583838000_8.6.a021899.26","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-9852-9"},{"key":"2018091410583838000_8.6.a021899.27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091309"},{"key":"2018091410583838000_8.6.a021899.28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/83810","article-title":"Bone morphogenetic protein-3 is a negative regulator of bone density","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"2018091410583838000_8.6.a021899.29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034124"},{"key":"2018091410583838000_8.6.a021899.30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.165530"},{"key":"2018091410583838000_8.6.a021899.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.05.001"},{"key":"2018091410583838000_8.6.a021899.32","doi-asserted-by":"publisher","DOI":"10.1086\/503204"},{"key":"2018091410583838000_8.6.a021899.33","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040216"},{"key":"2018091410583838000_8.6.a021899.34","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006"},{"key":"2018091410583838000_8.6.a021899.35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104340"},{"key":"2018091410583838000_8.6.a021899.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80257-3"},{"key":"2018091410583838000_8.6.a021899.37","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.22.2795"},{"key":"2018091410583838000_8.6.a021899.38","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1242\/jcs.112.20.3519","article-title":"Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation","volume":"112","year":"1999","journal-title":"J Cell Sci"},{"key":"2018091410583838000_8.6.a021899.39","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12067"},{"key":"2018091410583838000_8.6.a021899.40","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0254"},{"key":"2018091410583838000_8.6.a021899.41","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.11.3801"},{"key":"2018091410583838000_8.6.a021899.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.11.012"},{"key":"2018091410583838000_8.6.a021899.43","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1301"},{"key":"2018091410583838000_8.6.a021899.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.10.093"},{"key":"2018091410583838000_8.6.a021899.45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801681200"},{"key":"2018091410583838000_8.6.a021899.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.035"},{"key":"2018091410583838000_8.6.a021899.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.009"},{"key":"2018091410583838000_8.6.a021899.48","doi-asserted-by":"publisher","DOI":"10.1038\/6821"},{"key":"2018091410583838000_8.6.a021899.49","first-page":"253","article-title":"Functional analysis of the TGF-\u03b2 receptor\/Smad pathway through gene ablation in mice","volume":"44","year":"2000","journal-title":"Int J Dev Biol"},{"key":"2018091410583838000_8.6.a021899.50","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00386-1"},{"key":"2018091410583838000_8.6.a021899.51","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00094-7"},{"key":"2018091410583838000_8.6.a021899.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.878"},{"key":"2018091410583838000_8.6.a021899.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.03.008"},{"key":"2018091410583838000_8.6.a021899.54","doi-asserted-by":"publisher","DOI":"10.1038\/nature01245"},{"key":"2018091410583838000_8.6.a021899.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2012.02.001"},{"key":"2018091410583838000_8.6.a021899.56","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1127"},{"key":"2018091410583838000_8.6.a021899.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.015"},{"key":"2018091410583838000_8.6.a021899.58","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1221"},{"key":"2018091410583838000_8.6.a021899.59","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.067"},{"key":"2018091410583838000_8.6.a021899.60","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4358"},{"key":"2018091410583838000_8.6.a021899.61","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.178434"},{"key":"2018091410583838000_8.6.a021899.62","doi-asserted-by":"publisher","DOI":"10.1002\/path.1785"},{"key":"2018091410583838000_8.6.a021899.63","first-page":"19838","article-title":"Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells","volume":"278","year":"1999","journal-title":"J Biol Chem"},{"key":"2018091410583838000_8.6.a021899.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.10.021"},{"key":"2018091410583838000_8.6.a021899.65","doi-asserted-by":"publisher","DOI":"10.1038\/88919"},{"key":"2018091410583838000_8.6.a021899.66","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1152\/ajprenal.2000.279.1.F130","article-title":"Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction","volume":"279","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"2018091410583838000_8.6.a021899.67","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511435939"},{"key":"2018091410583838000_8.6.a021899.68","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199607)206:3<318::AID-AJA9>3.0.CO;2-L"},{"key":"2018091410583838000_8.6.a021899.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.11.013"},{"key":"2018091410583838000_8.6.a021899.70","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01500-6"},{"key":"2018091410583838000_8.6.a021899.71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.9.6075"},{"key":"2018091410583838000_8.6.a021899.72","doi-asserted-by":"publisher","DOI":"10.3109\/08977199609003229"},{"key":"2018091410583838000_8.6.a021899.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.05.017"},{"key":"2018091410583838000_8.6.a021899.74","doi-asserted-by":"publisher","DOI":"10.1038\/nature01458"},{"key":"2018091410583838000_8.6.a021899.75","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1999.00250.x"},{"key":"2018091410583838000_8.6.a021899.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.06.022"},{"key":"2018091410583838000_8.6.a021899.77","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151515"},{"key":"2018091410583838000_8.6.a021899.78","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116848"},{"key":"2018091410583838000_8.6.a021899.79","doi-asserted-by":"publisher","DOI":"10.1016\/S1349-0079(10)80006-4"},{"key":"2018091410583838000_8.6.a021899.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2012.03.004"},{"key":"2018091410583838000_8.6.a021899.81","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.6.1755"},{"key":"2018091410583838000_8.6.a021899.82","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<340::AID-DVG4>3.0.CO;2-6"},{"key":"2018091410583838000_8.6.a021899.83","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2002.00573.x"},{"key":"2018091410583838000_8.6.a021899.84","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.232"},{"key":"2018091410583838000_8.6.a021899.85","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2704"},{"key":"2018091410583838000_8.6.a021899.86","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5247.360"},{"key":"2018091410583838000_8.6.a021899.87","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90510-J"},{"key":"2018091410583838000_8.6.a021899.88","doi-asserted-by":"publisher","DOI":"10.1038\/75903"},{"key":"2018091410583838000_8.6.a021899.89","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.13.4627-4636.2003"},{"key":"2018091410583838000_8.6.a021899.90","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.059"},{"key":"2018091410583838000_8.6.a021899.91","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1168"},{"key":"2018091410583838000_8.6.a021899.92","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050562"},{"key":"2018091410583838000_8.6.a021899.93","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111023200"},{"key":"2018091410583838000_8.6.a021899.94","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.10.4241-4254.2004"},{"key":"2018091410583838000_8.6.a021899.95","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.24.6664"},{"key":"2018091410583838000_8.6.a021899.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.08.011"},{"key":"2018091410583838000_8.6.a021899.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.08.003"},{"key":"2018091410583838000_8.6.a021899.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.12.005"},{"key":"2018091410583838000_8.6.a021899.99","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201708"},{"key":"2018091410583838000_8.6.a021899.100","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-472142"},{"key":"2018091410583838000_8.6.a021899.101","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12093"},{"key":"2018091410583838000_8.6.a021899.102","doi-asserted-by":"publisher","DOI":"10.1038\/nm1217"},{"key":"2018091410583838000_8.6.a021899.103","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.005"},{"key":"2018091410583838000_8.6.a021899.104","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106826200"},{"key":"2018091410583838000_8.6.a021899.105","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01177"},{"key":"2018091410583838000_8.6.a021899.106","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.22.2808"},{"key":"2018091410583838000_8.6.a021899.107","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.11.1657"},{"key":"2018091410583838000_8.6.a021899.108","doi-asserted-by":"publisher","DOI":"10.1038\/nature12207"},{"key":"2018091410583838000_8.6.a021899.109","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600067"},{"key":"2018091410583838000_8.6.a021899.110","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80425-0"},{"key":"2018091410583838000_8.6.a021899.111","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-480095"},{"key":"2018091410583838000_8.6.a021899.112","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0393"},{"key":"2018091410583838000_8.6.a021899.113","doi-asserted-by":"publisher","DOI":"10.1038\/10320"},{"key":"2018091410583838000_8.6.a021899.114","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2252"},{"key":"2018091410583838000_8.6.a021899.115","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9197"},{"key":"2018091410583838000_8.6.a021899.116","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208127"},{"key":"2018091410583838000_8.6.a021899.117","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp148"},{"key":"2018091410583838000_8.6.a021899.118","doi-asserted-by":"publisher","DOI":"10.1021\/cb300655w"},{"key":"2018091410583838000_8.6.a021899.119","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.191"},{"key":"2018091410583838000_8.6.a021899.120","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.16.5664-5679.2003"},{"key":"2018091410583838000_8.6.a021899.121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.02.135"},{"key":"2018091410583838000_8.6.a021899.122","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jbmr.5650090510","article-title":"Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing","volume":"9","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2018091410583838000_8.6.a021899.123","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00622-5"},{"key":"2018091410583838000_8.6.a021899.124","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00417"},{"key":"2018091410583838000_8.6.a021899.125","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.167643"},{"key":"2018091410583838000_8.6.a021899.126","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.028506"},{"key":"2018091410583838000_8.6.a021899.127","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235655"},{"key":"2018091410583838000_8.6.a021899.128","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.130286"},{"key":"2018091410583838000_8.6.a021899.129","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.353094"},{"key":"2018091410583838000_8.6.a021899.130","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2671-9"},{"key":"2018091410583838000_8.6.a021899.131","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.35.21345"},{"key":"2018091410583838000_8.6.a021899.132","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.028019"},{"key":"2018091410583838000_8.6.a021899.133","doi-asserted-by":"publisher","DOI":"10.1038\/46794"},{"key":"2018091410583838000_8.6.a021899.134","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/j.1460-2075.1990.tb07376.x","article-title":"OP-1 cDNA encodes an osteogenic protein in the TGF-\u03b2 family","volume":"9","year":"1990","journal-title":"EMBO J"},{"key":"2018091410583838000_8.6.a021899.135","doi-asserted-by":"crossref","first-page":"25220","DOI":"10.1016\/S0021-9258(19)74028-9","article-title":"Osteogenic protein-2. A new member of the transforming growth factor-\u03b2 superfamily expressed early in embryogenesis","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"2018091410583838000_8.6.a021899.136","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.12.007"},{"key":"2018091410583838000_8.6.a021899.137","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.2905"},{"key":"2018091410583838000_8.6.a021899.138","doi-asserted-by":"publisher","DOI":"10.1038\/ng1274"},{"key":"2018091410583838000_8.6.a021899.139","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02670.x"},{"key":"2018091410583838000_8.6.a021899.140","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.12.4558"},{"key":"2018091410583838000_8.6.a021899.141","doi-asserted-by":"publisher","DOI":"10.1038\/nature05349"},{"key":"2018091410583838000_8.6.a021899.142","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80424-9"},{"key":"2018091410583838000_8.6.a021899.143","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.08.004"},{"key":"2018091410583838000_8.6.a021899.144","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-18"},{"key":"2018091410583838000_8.6.a021899.145","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-407593"},{"key":"2018091410583838000_8.6.a021899.146","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.17.7632"},{"key":"2018091410583838000_8.6.a021899.147","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","article-title":"Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration","volume":"65","year":"2005","journal-title":"Cancer Res"},{"key":"2018091410583838000_8.6.a021899.148","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1432-1033.1996.0295n.x","article-title":"Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity","volume":"237","year":"1996","journal-title":"Eur J Biochem"},{"key":"2018091410583838000_8.6.a021899.149","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410034200"},{"key":"2018091410583838000_8.6.a021899.150","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.04.015"},{"key":"2018091410583838000_8.6.a021899.151","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.21.6591"},{"key":"2018091410583838000_8.6.a021899.152","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1016\/S0021-9258(19)38285-7","article-title":"Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-\u03b2 superfamily","volume":"265","year":"1990","journal-title":"J Biol Chem"},{"key":"2018091410583838000_8.6.a021899.153","doi-asserted-by":"crossref","first-page":"20352","DOI":"10.1016\/S0021-9258(19)88709-4","article-title":"Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"2018091410583838000_8.6.a021899.154","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6004"},{"key":"2018091410583838000_8.6.a021899.155","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062721"},{"key":"2018091410583838000_8.6.a021899.156","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2772"},{"key":"2018091410583838000_8.6.a021899.157","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.002949"},{"key":"2018091410583838000_8.6.a021899.158","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.078"},{"key":"2018091410583838000_8.6.a021899.159","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25118"},{"key":"2018091410583838000_8.6.a021899.160","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-188907000-00043"},{"key":"2018091410583838000_8.6.a021899.161","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00022-2"},{"key":"2018091410583838000_8.6.a021899.162","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608223350804"},{"key":"2018091410583838000_8.6.a021899.163","first-page":"3462","article-title":"The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization","volume":"119","year":"2009","journal-title":"J Clin Invest"},{"key":"2018091410583838000_8.6.a021899.164","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-012-0381-1"},{"key":"2018091410583838000_8.6.a021899.165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.08.022"},{"key":"2018091410583838000_8.6.a021899.166","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<321::AID-DVG3>3.0.CO;2-8"},{"key":"2018091410583838000_8.6.a021899.167","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-313064"},{"key":"2018091410583838000_8.6.a021899.168","doi-asserted-by":"publisher","DOI":"10.1038\/368639a0"},{"key":"2018091410583838000_8.6.a021899.169","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2629"},{"key":"2018091410583838000_8.6.a021899.170","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6219"},{"key":"2018091410583838000_8.6.a021899.171","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvm215"},{"key":"2018091410583838000_8.6.a021899.172","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061556"},{"key":"2018091410583838000_8.6.a021899.173","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300937200"},{"key":"2018091410583838000_8.6.a021899.174","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"2018091410583838000_8.6.a021899.175","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"2018091410583838000_8.6.a021899.176","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8200"},{"key":"2018091410583838000_8.6.a021899.177","doi-asserted-by":"crossref","first-page":"16985","DOI":"10.1016\/S0021-9258(17)32506-1","article-title":"Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4","volume":"269","year":"1994","journal-title":"J Biol Chem"},{"key":"2018091410583838000_8.6.a021899.178","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-58"},{"key":"2018091410583838000_8.6.a021899.179","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603124103"},{"key":"2018091410583838000_8.6.a021899.180","doi-asserted-by":"publisher","DOI":"10.1038\/nature07221"},{"key":"2018091410583838000_8.6.a021899.181","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.216903"},{"key":"2018091410583838000_8.6.a021899.182","doi-asserted-by":"publisher","DOI":"10.1038\/srep07596"},{"key":"2018091410583838000_8.6.a021899.183","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.1.161"},{"key":"2018091410583838000_8.6.a021899.184","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<533::AID-AJA6>3.0.CO;2-I"},{"key":"2018091410583838000_8.6.a021899.185","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5391.1136"},{"key":"2018091410583838000_8.6.a021899.186","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"},{"key":"2018091410583838000_8.6.a021899.187","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"2018091410583838000_8.6.a021899.188","doi-asserted-by":"publisher","DOI":"10.1177\/00220345710500060601"},{"key":"2018091410583838000_8.6.a021899.189","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90678-J"},{"key":"2018091410583838000_8.6.a021899.190","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000033830.36431.46"},{"key":"2018091410583838000_8.6.a021899.191","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.486"},{"key":"2018091410583838000_8.6.a021899.192","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.560"},{"key":"2018091410583838000_8.6.a021899.193","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2237"},{"key":"2018091410583838000_8.6.a021899.194","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.24.9484"},{"key":"2018091410583838000_8.6.a021899.195","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.6.2220"},{"key":"2018091410583838000_8.6.a021899.196","doi-asserted-by":"publisher","DOI":"10.3109\/08977199308991582"},{"key":"2018091410583838000_8.6.a021899.197","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.09.012"},{"key":"2018091410583838000_8.6.a021899.198","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.10.010"},{"key":"2018091410583838000_8.6.a021899.199","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512448660"},{"key":"2018091410583838000_8.6.a021899.200","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510837112"},{"key":"2018091410583838000_8.6.a021899.201","first-page":"871","article-title":"BMP8b increases brown adipose tissue thermogenesis through both central and peripheral actions","volume":"49","year":"2012","journal-title":"Cell"},{"key":"2018091410583838000_8.6.a021899.202","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.10.005"},{"key":"2018091410583838000_8.6.a021899.203","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211134"},{"key":"2018091410583838000_8.6.a021899.204","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119537"},{"key":"2018091410583838000_8.6.a021899.205","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1562"},{"key":"2018091410583838000_8.6.a021899.206","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"2018091410583838000_8.6.a021899.207","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.045"},{"key":"2018091410583838000_8.6.a021899.208","doi-asserted-by":"publisher","DOI":"10.1089\/10445490152122479"},{"key":"2018091410583838000_8.6.a021899.209","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.075"},{"key":"2018091410583838000_8.6.a021899.210","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25445"},{"key":"2018091410583838000_8.6.a021899.211","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0289"},{"key":"2018091410583838000_8.6.a021899.212","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00456-13"},{"key":"2018091410583838000_8.6.a021899.213","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00847-X"},{"key":"2018091410583838000_8.6.a021899.214","doi-asserted-by":"publisher","DOI":"10.1038\/nature06968"},{"key":"2018091410583838000_8.6.a021899.215","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310479110"},{"key":"2018091410583838000_8.6.a021899.216","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502825200"},{"key":"2018091410583838000_8.6.a021899.217","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1888"},{"key":"2018091410583838000_8.6.a021899.218","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.54"},{"key":"2018091410583838000_8.6.a021899.219","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23230"},{"key":"2018091410583838000_8.6.a021899.220","doi-asserted-by":"publisher","DOI":"10.1038\/nm888"},{"key":"2018091410583838000_8.6.a021899.221","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1242\/dev.129.17.4135","article-title":"Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis","volume":"129","year":"2002","journal-title":"Development"},{"key":"2018091410583838000_8.6.a021899.222","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.9.1593"},{"key":"2018091410583838000_8.6.a021899.223","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2012-4276"},{"key":"2018091410583838000_8.6.a021899.224","doi-asserted-by":"publisher","DOI":"10.1086\/323703"}],"container-title":["Cold Spring Harbor Perspectives in Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/cshperspect.a021899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T04:20:13Z","timestamp":1718598013000},"score":1,"resource":{"primary":{"URL":"http:\/\/cshperspectives.cshlp.org\/lookup\/doi\/10.1101\/cshperspect.a021899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":224,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,1]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1101\/cshperspect.a021899"],"URL":"https:\/\/doi.org\/10.1101\/cshperspect.a021899","relation":{},"ISSN":["1943-0264"],"issn-type":[{"value":"1943-0264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}