{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:35Z","timestamp":1791296855176,"version":"4.1.0"},"reference-count":390,"publisher":"Cold Spring Harbor Laboratory","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Perspect Biol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1101\/cshperspect.a022210","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:31:49Z","timestamp":1490661109000},"page":"a022210","source":"Crossref","is-referenced-by-count":349,"title":["TGF-\u03b2 Signaling in Control of Cardiovascular Function"],"prefix":"10.1101","volume":"10","author":[{"given":"Marie-Jos\u00e9","family":"Goumans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"ten Dijke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"2018091410571683000_10.2.a022210.1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.030833"},{"key":"2018091410571683000_10.2.a022210.2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2183","article-title":"Molecular regulation of angiogenesis and lymphangiogenesis","volume":"8","year":"2007","journal-title":"Nat Res Mol Cell Biol"},{"key":"2018091410571683000_10.2.a022210.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3810"},{"key":"2018091410571683000_10.2.a022210.4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1242\/dev.108.4.645","article-title":"TGF-\u03b2 in murine morphogenetic processes: The early embryo and cardiogenesis","volume":"108","year":"1990","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.08.2011.4585"},{"key":"2018091410571683000_10.2.a022210.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00051-X"},{"key":"2018091410571683000_10.2.a022210.7","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.035246"},{"key":"2018091410571683000_10.2.a022210.8","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311416259"},{"key":"2018091410571683000_10.2.a022210.9","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00229"},{"key":"2018091410571683000_10.2.a022210.10","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312172"},{"key":"2018091410571683000_10.2.a022210.11","first-page":"35","article-title":"Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia","volume":"6","year":"2015","journal-title":"Front Genet"},{"key":"2018091410571683000_10.2.a022210.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9383-4"},{"key":"2018091410571683000_10.2.a022210.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.001"},{"key":"2018091410571683000_10.2.a022210.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.03.004"},{"key":"2018091410571683000_10.2.a022210.15","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9534"},{"key":"2018091410571683000_10.2.a022210.16","doi-asserted-by":"publisher","DOI":"10.1038\/12971"},{"key":"2018091410571683000_10.2.a022210.17","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00044-3"},{"key":"2018091410571683000_10.2.a022210.18","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21854"},{"key":"2018091410571683000_10.2.a022210.19","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22702"},{"key":"2018091410571683000_10.2.a022210.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2745"},{"key":"2018091410571683000_10.2.a022210.21","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90448-N"},{"key":"2018091410571683000_10.2.a022210.22","first-page":"2155","article-title":"A fourth locus for hereditary hemorrhagic telangiectasia maps to chromosome 7","volume":"140","year":"2006","journal-title":"Am J Med Genet A"},{"key":"2018091410571683000_10.2.a022210.23","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130538"},{"key":"2018091410571683000_10.2.a022210.24","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3448"},{"key":"2018091410571683000_10.2.a022210.25","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230943"},{"key":"2018091410571683000_10.2.a022210.26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302721"},{"key":"2018091410571683000_10.2.a022210.27","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9670"},{"key":"2018091410571683000_10.2.a022210.28","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00239.2004"},{"key":"2018091410571683000_10.2.a022210.29","doi-asserted-by":"publisher","DOI":"10.1215\/S1152851705000232"},{"key":"2018091410571683000_10.2.a022210.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.07.003"},{"key":"2018091410571683000_10.2.a022210.31","doi-asserted-by":"publisher","DOI":"10.2174\/2211536611201010002"},{"key":"2018091410571683000_10.2.a022210.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.04.014"},{"key":"2018091410571683000_10.2.a022210.33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2883"},{"key":"2018091410571683000_10.2.a022210.34","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283557d4c"},{"key":"2018091410571683000_10.2.a022210.35","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-207"},{"key":"2018091410571683000_10.2.a022210.36","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000256466.65450.ce"},{"key":"2018091410571683000_10.2.a022210.37","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.522284"},{"key":"2018091410571683000_10.2.a022210.38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8088"},{"key":"2018091410571683000_10.2.a022210.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64960-7"},{"key":"2018091410571683000_10.2.a022210.40","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(01)00062-7"},{"key":"2018091410571683000_10.2.a022210.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64673-1"},{"key":"2018091410571683000_10.2.a022210.42","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9211"},{"key":"2018091410571683000_10.2.a022210.43","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.1065"},{"key":"2018091410571683000_10.2.a022210.44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503328200"},{"key":"2018091410571683000_10.2.a022210.45","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018960"},{"key":"2018091410571683000_10.2.a022210.46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001878"},{"key":"2018091410571683000_10.2.a022210.47","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22165"},{"key":"2018091410571683000_10.2.a022210.48","doi-asserted-by":"publisher","DOI":"10.1038\/nm742"},{"key":"2018091410571683000_10.2.a022210.49","doi-asserted-by":"publisher","DOI":"10.1038\/nature10144"},{"key":"2018091410571683000_10.2.a022210.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.10.002"},{"key":"2018091410571683000_10.2.a022210.51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511599200"},{"key":"2018091410571683000_10.2.a022210.52","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01529"},{"key":"2018091410571683000_10.2.a022210.53","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.013169"},{"key":"2018091410571683000_10.2.a022210.54","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021923"},{"key":"2018091410571683000_10.2.a022210.55","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9594"},{"key":"2018091410571683000_10.2.a022210.56","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/dev.126.8.1631","article-title":"Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects","volume":"126","year":"1999","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608167"},{"key":"2018091410571683000_10.2.a022210.58","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg224"},{"key":"2018091410571683000_10.2.a022210.59","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126897.41658.81"},{"key":"2018091410571683000_10.2.a022210.60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507771200"},{"key":"2018091410571683000_10.2.a022210.61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57513"},{"key":"2018091410571683000_10.2.a022210.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.10.021"},{"key":"2018091410571683000_10.2.a022210.63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306074110"},{"key":"2018091410571683000_10.2.a022210.64","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003655"},{"key":"2018091410571683000_10.2.a022210.65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00454.2014"},{"key":"2018091410571683000_10.2.a022210.66","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506181"},{"key":"2018091410571683000_10.2.a022210.67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063138"},{"key":"2018091410571683000_10.2.a022210.68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.174367"},{"key":"2018091410571683000_10.2.a022210.69","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.028712"},{"key":"2018091410571683000_10.2.a022210.70","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.152082"},{"key":"2018091410571683000_10.2.a022210.71","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00422-6"},{"key":"2018091410571683000_10.2.a022210.72","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006927"},{"key":"2018091410571683000_10.2.a022210.73","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81460-9"},{"key":"2018091410571683000_10.2.a022210.74","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq308"},{"key":"2018091410571683000_10.2.a022210.75","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304412"},{"key":"2018091410571683000_10.2.a022210.76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00156.x"},{"key":"2018091410571683000_10.2.a022210.77","first-page":"428619","article-title":"A novel stent coated with antibodies to endoglin inhibits neointimal formation of porcine coronary arteries","volume":"2014","year":"2014","journal-title":"Biomed Res Int"},{"key":"2018091410571683000_10.2.a022210.78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091309"},{"key":"2018091410571683000_10.2.a022210.79","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3706"},{"key":"2018091410571683000_10.2.a022210.80","first-page":"6","article-title":"KLF4 is a key determinant in the development and progression of cerebral cavernous malformations","volume":"8","year":"2015","journal-title":"EMBO Mol Med"},{"key":"2018091410571683000_10.2.a022210.81","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016611824696"},{"key":"2018091410571683000_10.2.a022210.82","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034124"},{"key":"2018091410571683000_10.2.a022210.83","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504774200"},{"key":"2018091410571683000_10.2.a022210.84","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2012.654858"},{"key":"2018091410571683000_10.2.a022210.85","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3465"},{"key":"2018091410571683000_10.2.a022210.86","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006"},{"key":"2018091410571683000_10.2.a022210.87","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-133X(03)00029-2"},{"key":"2018091410571683000_10.2.a022210.88","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.121.6.1845","article-title":"Defective haematopoiesis and vasculogenesis in transforming growth factor-\u03b21 knock out mice","volume":"121","year":"1995","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.89","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"2018091410571683000_10.2.a022210.90","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2004.13.509"},{"key":"2018091410571683000_10.2.a022210.91","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCHEARTFAILURE.108.823070","article-title":"Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading","volume":"2","year":"2009","journal-title":"Cir Heart Fail"},{"key":"2018091410571683000_10.2.a022210.92","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.216101"},{"key":"2018091410571683000_10.2.a022210.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.033"},{"key":"2018091410571683000_10.2.a022210.94","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1246-y"},{"key":"2018091410571683000_10.2.a022210.95","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.05.027"},{"key":"2018091410571683000_10.2.a022210.96","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10618"},{"key":"2018091410571683000_10.2.a022210.97","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.231860"},{"key":"2018091410571683000_10.2.a022210.98","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2011.11.007"},{"key":"2018091410571683000_10.2.a022210.99","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.04.004"},{"key":"2018091410571683000_10.2.a022210.100","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0165"},{"key":"2018091410571683000_10.2.a022210.101","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.08.008"},{"key":"2018091410571683000_10.2.a022210.102","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2013.1205"},{"key":"2018091410571683000_10.2.a022210.103","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.21.022404.142018"},{"key":"2018091410571683000_10.2.a022210.104","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183609.55154.44"},{"key":"2018091410571683000_10.2.a022210.105","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24252"},{"key":"2018091410571683000_10.2.a022210.106","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11239-012-0840-5","article-title":"Novel treatments for epistaxis in hereditary hemorrhagic telangiectasia: A systematic review of the clinical experience with thalidomide","volume":"36","year":"2013","journal-title":"J Thromb Thrombolysis"},{"key":"2018091410571683000_10.2.a022210.107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107221"},{"key":"2018091410571683000_10.2.a022210.108","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0739-7"},{"key":"2018091410571683000_10.2.a022210.109","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.186593"},{"key":"2018091410571683000_10.2.a022210.110","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.127"},{"key":"2018091410571683000_10.2.a022210.111","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00152-1"},{"key":"2018091410571683000_10.2.a022210.112","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.041517"},{"key":"2018091410571683000_10.2.a022210.113","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ajmg.a.33206","article-title":"Overlapping spectra of SMAD4 mutations in juvenile polyposis JP and JP-HHT syndrome","volume":"152A","year":"2010","journal-title":"Am J Med Genet A"},{"key":"2018091410571683000_10.2.a022210.114","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69666"},{"key":"2018091410571683000_10.2.a022210.115","doi-asserted-by":"publisher","DOI":"10.1038\/72835"},{"key":"2018091410571683000_10.2.a022210.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.12.005"},{"key":"2018091410571683000_10.2.a022210.117","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1197-9"},{"key":"2018091410571683000_10.2.a022210.118","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006133"},{"key":"2018091410571683000_10.2.a022210.119","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1729"},{"key":"2018091410571683000_10.2.a022210.120","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs115"},{"key":"2018091410571683000_10.2.a022210.121","doi-asserted-by":"publisher","DOI":"10.1002\/path.2516"},{"key":"2018091410571683000_10.2.a022210.122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100310"},{"key":"2018091410571683000_10.2.a022210.123","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300154"},{"key":"2018091410571683000_10.2.a022210.124","first-page":"253","article-title":"Functional analysis of the TGF-\u03b2 receptor\/Smad pathway through gene ablation in mice","volume":"44","year":"2000","journal-title":"Int J Dev Biol"},{"key":"2018091410571683000_10.2.a022210.125","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1242\/dev.126.16.3473","article-title":"Transforming growth factor-\u03b2 signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice","volume":"126","year":"1999","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.126","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.7.1743"},{"key":"2018091410571683000_10.2.a022210.127","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(03)00142-7"},{"key":"2018091410571683000_10.2.a022210.128","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00386-1"},{"key":"2018091410571683000_10.2.a022210.129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2009.01.001"},{"key":"2018091410571683000_10.2.a022210.130","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.326"},{"key":"2018091410571683000_10.2.a022210.131","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031989"},{"key":"2018091410571683000_10.2.a022210.132","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000114567.76772.33"},{"key":"2018091410571683000_10.2.a022210.133","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu319"},{"key":"2018091410571683000_10.2.a022210.134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.01.027"},{"key":"2018091410571683000_10.2.a022210.135","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht334"},{"key":"2018091410571683000_10.2.a022210.136","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"2018091410571683000_10.2.a022210.137","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192152"},{"key":"2018091410571683000_10.2.a022210.138","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt083"},{"key":"2018091410571683000_10.2.a022210.139","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9436-3"},{"key":"2018091410571683000_10.2.a022210.140","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600919911"},{"key":"2018091410571683000_10.2.a022210.141","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022061"},{"key":"2018091410571683000_10.2.a022210.142","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2011.595411"},{"key":"2018091410571683000_10.2.a022210.143","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0743"},{"key":"2018091410571683000_10.2.a022210.144","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022053"},{"key":"2018091410571683000_10.2.a022210.145","doi-asserted-by":"publisher","DOI":"10.1038\/37284"},{"key":"2018091410571683000_10.2.a022210.146","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3176"},{"key":"2018091410571683000_10.2.a022210.147","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2362.2011.02587.x","article-title":"TGF-\u03b21 content in atherosclerotic plaques, TGF-\u03b21 serum concentrations and incident coronary events","volume":"42","year":"2012","journal-title":"Eur J Clin Invest"},{"key":"2018091410571683000_10.2.a022210.148","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-001-0537-5"},{"key":"2018091410571683000_10.2.a022210.149","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022079"},{"key":"2018091410571683000_10.2.a022210.150","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072139"},{"key":"2018091410571683000_10.2.a022210.151","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022103"},{"key":"2018091410571683000_10.2.a022210.152","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142145"},{"key":"2018091410571683000_10.2.a022210.153","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.221358"},{"key":"2018091410571683000_10.2.a022210.154","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00763-3"},{"key":"2018091410571683000_10.2.a022210.155","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192149"},{"key":"2018091410571683000_10.2.a022210.156","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.074773"},{"key":"2018091410571683000_10.2.a022210.157","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.03.006"},{"key":"2018091410571683000_10.2.a022210.158","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4193\/Rhin14.289","article-title":"Follow-up of Thalidomide treatment in patients with Hereditary Haemorrhagic Telangiectasia","volume":"53","year":"2015","journal-title":"Rhinology"},{"key":"2018091410571683000_10.2.a022210.159","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.010"},{"key":"2018091410571683000_10.2.a022210.160","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0063OC"},{"key":"2018091410571683000_10.2.a022210.161","first-page":"1355","article-title":"MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4","volume":"18","year":"2014","journal-title":"Expert Opin Ther Targets"},{"key":"2018091410571683000_10.2.a022210.162","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1451"},{"key":"2018091410571683000_10.2.a022210.163","doi-asserted-by":"publisher","DOI":"10.1080\/10408360490460933"},{"key":"2018091410571683000_10.2.a022210.164","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.137836"},{"key":"2018091410571683000_10.2.a022210.165","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2853"},{"key":"2018091410571683000_10.2.a022210.166","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq230"},{"key":"2018091410571683000_10.2.a022210.167","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1521"},{"key":"2018091410571683000_10.2.a022210.168","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.02.015"},{"key":"2018091410571683000_10.2.a022210.169","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-395772"},{"key":"2018091410571683000_10.2.a022210.170","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.05.017"},{"key":"2018091410571683000_10.2.a022210.171","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.02.015"},{"key":"2018091410571683000_10.2.a022210.172","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1605"},{"key":"2018091410571683000_10.2.a022210.173","doi-asserted-by":"publisher","DOI":"10.1242\/dev.095026"},{"key":"2018091410571683000_10.2.a022210.174","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4110\/in.2014.14.5.237","article-title":"Contrasting roles of different endoglin forms in atherosclerosis","volume":"14","year":"2014","journal-title":"Immune Netw"},{"key":"2018091410571683000_10.2.a022210.175","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02597"},{"key":"2018091410571683000_10.2.a022210.176","doi-asserted-by":"publisher","DOI":"10.1101\/gr.5.1.21"},{"key":"2018091410571683000_10.2.a022210.177","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1727208"},{"key":"2018091410571683000_10.2.a022210.178","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s12265-011-9320-0","article-title":"Translational research on the mitral valve: From developmental mechanisms to new therapies","volume":"4","year":"2011","journal-title":"J Cardiovasc Transl Res"},{"key":"2018091410571683000_10.2.a022210.179","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-415"},{"key":"2018091410571683000_10.2.a022210.180","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133605.89421.79"},{"key":"2018091410571683000_10.2.a022210.181","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"2018091410571683000_10.2.a022210.182","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.080002"},{"key":"2018091410571683000_10.2.a022210.183","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000965"},{"key":"2018091410571683000_10.2.a022210.184","doi-asserted-by":"publisher","DOI":"10.1038\/ni1013"},{"key":"2018091410571683000_10.2.a022210.185","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151515"},{"key":"2018091410571683000_10.2.a022210.186","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021899"},{"key":"2018091410571683000_10.2.a022210.187","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02336.x"},{"key":"2018091410571683000_10.2.a022210.188","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9277-x"},{"key":"2018091410571683000_10.2.a022210.189","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704883200"},{"key":"2018091410571683000_10.2.a022210.190","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601288200"},{"key":"2018091410571683000_10.2.a022210.191","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200403067"},{"key":"2018091410571683000_10.2.a022210.192","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1349-6"},{"key":"2018091410571683000_10.2.a022210.193","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.040352"},{"key":"2018091410571683000_10.2.a022210.194","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-014-9297-4"},{"key":"2018091410571683000_10.2.a022210.195","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22322"},{"key":"2018091410571683000_10.2.a022210.196","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.04.003"},{"key":"2018091410571683000_10.2.a022210.197","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1387\/ijdb.130302bk","article-title":"Remodeling of the myocardium in early trabeculation and cardiac valve formation; a role for TGF-\u03b22","volume":"57","year":"2013","journal-title":"Int J Dev Biol"},{"key":"2018091410571683000_10.2.a022210.198","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.234286"},{"key":"2018091410571683000_10.2.a022210.199","doi-asserted-by":"publisher","DOI":"10.1002\/stem.319"},{"key":"2018091410571683000_10.2.a022210.200","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.13.4495"},{"key":"2018091410571683000_10.2.a022210.201","doi-asserted-by":"publisher","DOI":"10.1038\/79226"},{"key":"2018091410571683000_10.2.a022210.202","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.7.1663"},{"key":"2018091410571683000_10.2.a022210.203","doi-asserted-by":"publisher","DOI":"10.1042\/bj3010765"},{"key":"2018091410571683000_10.2.a022210.204","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.5.1109"},{"key":"2018091410571683000_10.2.a022210.205","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600386"},{"key":"2018091410571683000_10.2.a022210.206","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2131"},{"key":"2018091410571683000_10.2.a022210.207","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0469"},{"key":"2018091410571683000_10.2.a022210.208","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.941468"},{"key":"2018091410571683000_10.2.a022210.209","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ymgme.2014.03.011","article-title":"The spectrum of FBN1, TGF\u03b2R1, TGF\u03b2R2 and ACTA2 variants in 594 individuals with suspected Marfan syndrome, Loeys\u2013Dietz syndrome or thoracic aortic aneurysms and dissections (TAAD)","volume":"112","year":"2014","journal-title":"Mol Genet Metab"},{"key":"2018091410571683000_10.2.a022210.210","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009224"},{"key":"2018091410571683000_10.2.a022210.211","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ejhg.2013.252","article-title":"A 1-bp duplication in TGF\u03b22 in three family members with a syndromic form of thoracic aortic aneurysm","volume":"22","year":"2014","journal-title":"Eur J Hum Genet"},{"key":"2018091410571683000_10.2.a022210.212","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-472142"},{"key":"2018091410571683000_10.2.a022210.213","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1534"},{"key":"2018091410571683000_10.2.a022210.214","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.01.011"},{"key":"2018091410571683000_10.2.a022210.215","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69942"},{"key":"2018091410571683000_10.2.a022210.216","doi-asserted-by":"publisher","DOI":"10.1038\/nature10146"},{"key":"2018091410571683000_10.2.a022210.217","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs106"},{"key":"2018091410571683000_10.2.a022210.218","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.6.2747"},{"key":"2018091410571683000_10.2.a022210.219","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.806505"},{"key":"2018091410571683000_10.2.a022210.220","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2349"},{"key":"2018091410571683000_10.2.a022210.221","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.048942"},{"key":"2018091410571683000_10.2.a022210.222","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086273"},{"key":"2018091410571683000_10.2.a022210.223","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511"},{"key":"2018091410571683000_10.2.a022210.224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"2018091410571683000_10.2.a022210.225","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3877"},{"key":"2018091410571683000_10.2.a022210.226","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00529.2009"},{"key":"2018091410571683000_10.2.a022210.227","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000019729.39500.2F"},{"key":"2018091410571683000_10.2.a022210.228","doi-asserted-by":"publisher","DOI":"10.1038\/nature12207"},{"key":"2018091410571683000_10.2.a022210.229","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300504"},{"key":"2018091410571683000_10.2.a022210.230","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.211037"},{"key":"2018091410571683000_10.2.a022210.231","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.253872"},{"key":"2018091410571683000_10.2.a022210.232","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001480108"},{"key":"2018091410571683000_10.2.a022210.233","doi-asserted-by":"publisher","DOI":"10.1161\/hq0701.092136"},{"key":"2018091410571683000_10.2.a022210.234","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3434"},{"key":"2018091410571683000_10.2.a022210.235","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1350705"},{"key":"2018091410571683000_10.2.a022210.236","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"2018091410571683000_10.2.a022210.237","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.04.004"},{"key":"2018091410571683000_10.2.a022210.238","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1691"},{"key":"2018091410571683000_10.2.a022210.239","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.253740"},{"key":"2018091410571683000_10.2.a022210.240","first-page":"400","article-title":"Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance","volume":"15","year":"2015","journal-title":"Int J Cardiol"},{"key":"2018091410571683000_10.2.a022210.241","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2708"},{"key":"2018091410571683000_10.2.a022210.242","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022095"},{"key":"2018091410571683000_10.2.a022210.243","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.12.070"},{"key":"2018091410571683000_10.2.a022210.244","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10314"},{"key":"2018091410571683000_10.2.a022210.245","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021873"},{"key":"2018091410571683000_10.2.a022210.246","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.156"},{"key":"2018091410571683000_10.2.a022210.247","doi-asserted-by":"publisher","DOI":"10.1242\/dev.030338"},{"key":"2018091410571683000_10.2.a022210.248","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80545-0"},{"key":"2018091410571683000_10.2.a022210.249","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.580977"},{"key":"2018091410571683000_10.2.a022210.250","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.1.193"},{"key":"2018091410571683000_10.2.a022210.251","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0074-9"},{"key":"2018091410571683000_10.2.a022210.252","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.5.785"},{"key":"2018091410571683000_10.2.a022210.253","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"2018091410571683000_10.2.a022210.254","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235655"},{"key":"2018091410571683000_10.2.a022210.255","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00304.2009"},{"key":"2018091410571683000_10.2.a022210.256","first-page":"461","article-title":"TGF\u03b21 suppresses vascular smooth muscle cell motility by expression of N-cadherin","volume":"392","year":"2011","journal-title":"Biol Chem"},{"key":"2018091410571683000_10.2.a022210.257","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0049OC"},{"key":"2018091410571683000_10.2.a022210.258","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.6.2626"},{"key":"2018091410571683000_10.2.a022210.259","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-120337"},{"key":"2018091410571683000_10.2.a022210.260","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165066.71481.8E"},{"key":"2018091410571683000_10.2.a022210.261","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31294"},{"key":"2018091410571683000_10.2.a022210.262","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302598"},{"key":"2018091410571683000_10.2.a022210.263","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0259"},{"key":"2018091410571683000_10.2.a022210.264","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"2018091410571683000_10.2.a022210.265","first-page":"83","article-title":"The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: A link to phenotype heterogeneity","volume":"2","year":"2013","journal-title":"Ann Cardiothorac Surg"},{"key":"2018091410571683000_10.2.a022210.266","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304996"},{"key":"2018091410571683000_10.2.a022210.267","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.250"},{"key":"2018091410571683000_10.2.a022210.268","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537340"},{"key":"2018091410571683000_10.2.a022210.269","first-page":"603","article-title":"Protein and mRNA expression levels of VEGF-A and TGF-\u03b21 in different types of human coronary atherosclerotic lesions","volume":"15","year":"2005","journal-title":"Int J Mol Med"},{"key":"2018091410571683000_10.2.a022210.270","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8.195"},{"key":"2018091410571683000_10.2.a022210.271","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.06.006"},{"key":"2018091410571683000_10.2.a022210.272","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-107359"},{"key":"2018091410571683000_10.2.a022210.273","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MBC.0b013e32834a040c","article-title":"Deep vein thrombosis induced by thalidomide to control epistaxis secondary to hereditary haemorrhagic telangiectasia","volume":"22","year":"2011","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2018091410571683000_10.2.a022210.274","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1043"},{"key":"2018091410571683000_10.2.a022210.275","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208644"},{"key":"2018091410571683000_10.2.a022210.276","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.283"},{"key":"2018091410571683000_10.2.a022210.277","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.15.2019"},{"key":"2018091410571683000_10.2.a022210.278","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-02-0069"},{"key":"2018091410571683000_10.2.a022210.279","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.039"},{"key":"2018091410571683000_10.2.a022210.280","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00336.2014"},{"key":"2018091410571683000_10.2.a022210.281","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-409"},{"key":"2018091410571683000_10.2.a022210.282","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.09.002"},{"key":"2018091410571683000_10.2.a022210.283","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000190604.90049.71"},{"key":"2018091410571683000_10.2.a022210.284","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.006767"},{"key":"2018091410571683000_10.2.a022210.285","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2006.12.006"},{"key":"2018091410571683000_10.2.a022210.286","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2007.04.006"},{"key":"2018091410571683000_10.2.a022210.287","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3390\/cancers4030618","article-title":"Macrophage-mediated lymphangiogenesis: The emerging role of macrophages as lymphatic endothelial progenitors","volume":"4","year":"2012","journal-title":"Cancer"},{"key":"2018091410571683000_10.2.a022210.288","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248161"},{"key":"2018091410571683000_10.2.a022210.289","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040990"},{"key":"2018091410571683000_10.2.a022210.290","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.45"},{"key":"2018091410571683000_10.2.a022210.291","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.08.079"},{"key":"2018091410571683000_10.2.a022210.292","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijcard.2012.09.029","article-title":"Thoracic aortic-aneurysm and dissection in association with significant mitral valve disease caused by mutations in TGF\u03b22","volume":"165","year":"2013","journal-title":"Int J Cardiol"},{"key":"2018091410571683000_10.2.a022210.293","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13586"},{"key":"2018091410571683000_10.2.a022210.294","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-407593"},{"key":"2018091410571683000_10.2.a022210.295","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36056"},{"key":"2018091410571683000_10.2.a022210.296","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.carpath.2015.07.009","article-title":"TGF-\u03b21 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse","volume":"24","year":"2015","journal-title":"Cardiovasc Pathol"},{"key":"2018091410571683000_10.2.a022210.297","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318607"},{"key":"2018091410571683000_10.2.a022210.298","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.05.005"},{"key":"2018091410571683000_10.2.a022210.299","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021907"},{"key":"2018091410571683000_10.2.a022210.300","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22376"},{"key":"2018091410571683000_10.2.a022210.301","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00578.2001"},{"key":"2018091410571683000_10.2.a022210.302","first-page":"383","article-title":"How the Smads regulate transcription","volume":"2008","year":"2008","journal-title":"Int J Biochem Cell"},{"key":"2018091410571683000_10.2.a022210.303","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00076-6"},{"key":"2018091410571683000_10.2.a022210.304","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.041"},{"key":"2018091410571683000_10.2.a022210.305","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGF-\u03b22 knockout mice have multiple developmental defects that are non-overlapping with other TGF-\u03b2 knockout phenotypes","volume":"124","year":"1997","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.306","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm097"},{"key":"2018091410571683000_10.2.a022210.307","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.002949"},{"key":"2018091410571683000_10.2.a022210.308","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.61"},{"key":"2018091410571683000_10.2.a022210.309","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7304"},{"key":"2018091410571683000_10.2.a022210.310","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091249"},{"key":"2018091410571683000_10.2.a022210.311","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.00985.x"},{"key":"2018091410571683000_10.2.a022210.312","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02183.x"},{"key":"2018091410571683000_10.2.a022210.313","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2012.01561.x"},{"key":"2018091410571683000_10.2.a022210.314","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-199166"},{"key":"2018091410571683000_10.2.a022210.315","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-5131-6"},{"key":"2018091410571683000_10.2.a022210.316","doi-asserted-by":"publisher","DOI":"10.1038\/nature10152"},{"key":"2018091410571683000_10.2.a022210.317","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.282"},{"key":"2018091410571683000_10.2.a022210.318","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.940858"},{"key":"2018091410571683000_10.2.a022210.319","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00221.2004"},{"key":"2018091410571683000_10.2.a022210.320","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.1.107"},{"key":"2018091410571683000_10.2.a022210.321","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.492488"},{"key":"2018091410571683000_10.2.a022210.322","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.91519.2007"},{"key":"2018091410571683000_10.2.a022210.323","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00158-1"},{"key":"2018091410571683000_10.2.a022210.324","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.035"},{"key":"2018091410571683000_10.2.a022210.325","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.06.015"},{"key":"2018091410571683000_10.2.a022210.326","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65592"},{"key":"2018091410571683000_10.2.a022210.327","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2061LE"},{"key":"2018091410571683000_10.2.a022210.328","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.07.038"},{"key":"2018091410571683000_10.2.a022210.329","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.12.4371-4385.2003"},{"key":"2018091410571683000_10.2.a022210.330","doi-asserted-by":"publisher","DOI":"10.1101\/gad.229102"},{"key":"2018091410571683000_10.2.a022210.331","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20871"},{"key":"2018091410571683000_10.2.a022210.332","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.771"},{"key":"2018091410571683000_10.2.a022210.333","doi-asserted-by":"crossref","first-page":"71001","DOI":"10.1115\/1.4024349","article-title":"The role of cardiac fibroblasts in extracellular matrix-mediated signaling during normal and pathological cardiac development","volume":"135","year":"2013","journal-title":"J Biomech Eng"},{"key":"2018091410571683000_10.2.a022210.334","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.12.038"},{"key":"2018091410571683000_10.2.a022210.335","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.061556"},{"key":"2018091410571683000_10.2.a022210.336","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000269"},{"key":"2018091410571683000_10.2.a022210.337","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2004.09.003"},{"key":"2018091410571683000_10.2.a022210.338","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000901"},{"key":"2018091410571683000_10.2.a022210.339","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00100-0"},{"key":"2018091410571683000_10.2.a022210.340","doi-asserted-by":"publisher","DOI":"10.1161\/hh0901.090440"},{"key":"2018091410571683000_10.2.a022210.341","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2262"},{"key":"2018091410571683000_10.2.a022210.342","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9101-9"},{"key":"2018091410571683000_10.2.a022210.343","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.atherosclerosis.2009.09.073","article-title":"Assessment of the association between genetic polymorphisms in transforming growth factor-\u03b2, and its binding protein (LTBP), and the presence, and expansion, of abdominal aortic aneurysm","volume":"209","year":"2010","journal-title":"Atherosclerosis"},{"key":"2018091410571683000_10.2.a022210.344","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu184"},{"key":"2018091410571683000_10.2.a022210.345","doi-asserted-by":"publisher","DOI":"10.1242\/dev.008599"},{"key":"2018091410571683000_10.2.a022210.346","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22521"},{"key":"2018091410571683000_10.2.a022210.347","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1189-3"},{"key":"2018091410571683000_10.2.a022210.348","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.062844"},{"key":"2018091410571683000_10.2.a022210.349","first-page":"e50546","article-title":"Whole mount immunofluorescent staining of the neonatal mouse retina to investigate angiogenesis in vivo","volume":"77","year":"2013","journal-title":"J Vis Exp"},{"key":"2018091410571683000_10.2.a022210.350","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098646"},{"key":"2018091410571683000_10.2.a022210.351","doi-asserted-by":"publisher","DOI":"10.1038\/81634"},{"key":"2018091410571683000_10.2.a022210.352","doi-asserted-by":"publisher","DOI":"10.1038\/ng.744"},{"key":"2018091410571683000_10.2.a022210.353","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100382"},{"key":"2018091410571683000_10.2.a022210.354","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.052"},{"key":"2018091410571683000_10.2.a022210.355","doi-asserted-by":"publisher","DOI":"10.2174\/138920111798808338"},{"key":"2018091410571683000_10.2.a022210.356","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2174\/13895575113139990065","article-title":"Activin Receptor-like kinase 1: A novel anti-angiogenesis target from TGF-\u03b2 family","volume":"13","year":"2013","journal-title":"Mini Rev Med Chem"},{"key":"2018091410571683000_10.2.a022210.357","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000136520.07995.aa"},{"key":"2018091410571683000_10.2.a022210.358","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302161"},{"key":"2018091410571683000_10.2.a022210.359","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38136"},{"key":"2018091410571683000_10.2.a022210.360","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1003"},{"key":"2018091410571683000_10.2.a022210.361","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084188"},{"key":"2018091410571683000_10.2.a022210.362","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303852"},{"key":"2018091410571683000_10.2.a022210.363","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.162"},{"key":"2018091410571683000_10.2.a022210.364","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305147"},{"key":"2018091410571683000_10.2.a022210.365","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070195"},{"key":"2018091410571683000_10.2.a022210.366","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35852"},{"key":"2018091410571683000_10.2.a022210.367","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.07.004"},{"key":"2018091410571683000_10.2.a022210.368","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008830"},{"key":"2018091410571683000_10.2.a022210.369","doi-asserted-by":"publisher","DOI":"10.1038\/370341a0"},{"key":"2018091410571683000_10.2.a022210.370","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.02.012"},{"key":"2018091410571683000_10.2.a022210.371","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2005.11.004"},{"key":"2018091410571683000_10.2.a022210.372","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.03.014"},{"key":"2018091410571683000_10.2.a022210.373","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.09.016"},{"key":"2018091410571683000_10.2.a022210.374","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5244.2008"},{"key":"2018091410571683000_10.2.a022210.375","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71609"},{"key":"2018091410571683000_10.2.a022210.376","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/978-3-7091-1646-3_2","article-title":"Transcriptional control of lymphatic endothelial cell type specification","volume":"214","year":"2014","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"2018091410571683000_10.2.a022210.377","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3667"},{"key":"2018091410571683000_10.2.a022210.378","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1242\/dev.126.8.1571","article-title":"Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5","volume":"126","year":"1999","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.379","doi-asserted-by":"crossref","first-page":"35444","DOI":"10.1038\/srep35444","article-title":"Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"2018091410571683000_10.2.a022210.380","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn355"},{"key":"2018091410571683000_10.2.a022210.381","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310479110"},{"key":"2018091410571683000_10.2.a022210.382","doi-asserted-by":"publisher","DOI":"10.1038\/nm1613"},{"key":"2018091410571683000_10.2.a022210.383","first-page":"a022129","article-title":"Non-Smad signaling pathways of the TGF-\u03b2 family","volume":"8","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2018091410571683000_10.2.a022210.384","doi-asserted-by":"publisher","DOI":"10.1038\/75037"},{"key":"2018091410571683000_10.2.a022210.385","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.25"},{"key":"2018091410571683000_10.2.a022210.386","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.308040"},{"key":"2018091410571683000_10.2.a022210.387","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1242\/dev.129.12.2891","article-title":"\u03b28 integrins are required for vascular morphogenesis in mouse embryos","volume":"129","year":"2002","journal-title":"Development"},{"key":"2018091410571683000_10.2.a022210.388","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201208113"},{"key":"2018091410571683000_10.2.a022210.389","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12967-014-0252-8","article-title":"AAV2\/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis in LDLR-KO mice on high cholesterol diet","volume":"12","year":"2014","journal-title":"J Trans Med"},{"key":"2018091410571683000_10.2.a022210.390","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507652112"}],"container-title":["Cold Spring Harbor Perspectives in Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/cshperspect.a022210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T23:10:54Z","timestamp":1658877054000},"score":1,"resource":{"primary":{"URL":"http:\/\/cshperspectives.cshlp.org\/lookup\/doi\/10.1101\/cshperspect.a022210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,27]]},"references-count":390,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,1]]},"published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1101\/cshperspect.a022210"],"URL":"https:\/\/doi.org\/10.1101\/cshperspect.a022210","relation":{},"ISSN":["1943-0264"],"issn-type":[{"value":"1943-0264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,27]]}}}