{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:50:43Z","timestamp":1792432243225,"version":"4.5.0"},"reference-count":126,"publisher":"Cold Spring Harbor Laboratory","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Perspect Med"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1101\/cshperspect.a027029","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T19:22:30Z","timestamp":1464808950000},"page":"a027029","source":"Crossref","is-referenced-by-count":1042,"title":["Aminoglycosides: An Overview"],"prefix":"10.1101","volume":"6","author":[{"given":"Kevin M.","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa W.","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn E.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"2018091410281030000_6.6.a027029.1","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1007\/s11605-013-2379-y","article-title":"Selective decontamination of the digestive tract in gastrointestinal surgery: Useful in infection prevention? A systematic review","volume":"17","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"2018091410281030000_6.6.a027029.2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00572-10"},{"key":"2018091410281030000_6.6.a027029.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.3471717.x"},{"key":"2018091410281030000_6.6.a027029.4","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1128\/AAC.43.11.2624","article-title":"Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides","volume":"43","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"2018091410281030000_6.6.a027029.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00099-14"},{"key":"2018091410281030000_6.6.a027029.6","doi-asserted-by":"crossref","first-page":"24432","DOI":"10.3402\/ljm.v9.24432","article-title":"Prevalence of 16S rRNA methylase genes among \u03b2-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia","volume":"9","year":"2014","journal-title":"Libyan J Med"},{"key":"2018091410281030000_6.6.a027029.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"2018091410281030000_6.6.a027029.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.09.004"},{"key":"2018091410281030000_6.6.a027029.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02452.x"},{"key":"2018091410281030000_6.6.a027029.10","doi-asserted-by":"publisher","DOI":"10.1054\/drup.2001.0197"},{"key":"2018091410281030000_6.6.a027029.11","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936020-00001"},{"key":"2018091410281030000_6.6.a027029.12","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90349-4"},{"key":"2018091410281030000_6.6.a027029.13","unstructured":"Bell J , Andersson P , Jones R , Turnidge J . 2010. 16S rRNA methylase containing Enterobacteriaceae in the SENTRY Asia-Pacific region frequently harbour plasmid-mediated quinolone resistance CTXM types. 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Abstract O559. Vienna, April 10\u201313."},{"key":"2018091410281030000_6.6.a027029.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202657"},{"key":"2018091410281030000_6.6.a027029.15","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(71)80282-X"},{"key":"2018091410281030000_6.6.a027029.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.08.016"},{"key":"2018091410281030000_6.6.a027029.17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90452-3"},{"key":"2018091410281030000_6.6.a027029.18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2165\/00003495-197612030-00002","article-title":"Tobramycin: A review of its antibacterial and pharmacokinetic properties and therapeutic use","volume":"12","year":"1976","journal-title":"Drugs"},{"key":"2018091410281030000_6.6.a027029.19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-11"},{"key":"2018091410281030000_6.6.a027029.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1313-7"},{"key":"2018091410281030000_6.6.a027029.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-200"},{"key":"2018091410281030000_6.6.a027029.22","unstructured":"Castanheira M , Costello SE , Jones RN , Mendes RE . 2015. Prevalence of aminoglycoside resistance genes among contemporary Gram-negative resistant isolates collected worldwide. 25th European Congress of Clinical Microbriology and Infectious Diseases (ECCMID), Abstract O011. Copenhagen, April 25\u201328."},{"key":"2018091410281030000_6.6.a027029.23","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787581879"},{"key":"2018091410281030000_6.6.a027029.24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.9.1896"},{"key":"2018091410281030000_6.6.a027029.25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.7.1447"},{"key":"2018091410281030000_6.6.a027029.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.11.006"},{"key":"2018091410281030000_6.6.a027029.27","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/27.1.29"},{"key":"2018091410281030000_6.6.a027029.28","first-page":"D1","article-title":"Aminoglycoside resistance mediated by the bifunctional enzyme 6\u2032-N-aminoglycoside acetyltransferase-2\u2033-O-aminoglycoside phosphotransferase","volume":"4","year":"1999","journal-title":"Front Biosci"},{"key":"2018091410281030000_6.6.a027029.29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.43.100189.001231"},{"key":"2018091410281030000_6.6.a027029.30","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70322-5"},{"key":"2018091410281030000_6.6.a027029.31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1128\/MMBR.51.3.341-350.1987","article-title":"Mechanism of bactericidal action of aminoglycosides","volume":"51","year":"1987","journal-title":"Microbiol Rev"},{"key":"2018091410281030000_6.6.a027029.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.6164"},{"key":"2018091410281030000_6.6.a027029.33","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827e83af"},{"key":"2018091410281030000_6.6.a027029.34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.21.2763"},{"key":"2018091410281030000_6.6.a027029.35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.491-496.2004"},{"key":"2018091410281030000_6.6.a027029.36","doi-asserted-by":"publisher","DOI":"10.1086\/520991"},{"key":"2018091410281030000_6.6.a027029.37","first-page":"519","article-title":"Horizontal gene transfer-emerging multidrug resistance in hospital bacteria","volume":"24","year":"2003","journal-title":"Acta Pharmacol Sin"},{"key":"2018091410281030000_6.6.a027029.38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1128\/CMR.1.2.139","article-title":"Antibiotic combinations: Should they be tested?","volume":"1","year":"1988","journal-title":"Clin Microbiol Rev"},{"key":"2018091410281030000_6.6.a027029.39","doi-asserted-by":"publisher","DOI":"10.1186\/cc5032"},{"key":"2018091410281030000_6.6.a027029.40","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1139\/w04-069","article-title":"Genetic characterization of high-level gentamicin-resistant strains of Enterococcus faecalis in Iran","volume":"50","year":"2004","journal-title":"Can J Microbiol"},{"key":"2018091410281030000_6.6.a027029.41","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku432"},{"key":"2018091410281030000_6.6.a027029.42","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"2018091410281030000_6.6.a027029.43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.38.100184.001321"},{"key":"2018091410281030000_6.6.a027029.44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.19.5.777"},{"key":"2018091410281030000_6.6.a027029.45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1309"},{"key":"2018091410281030000_6.6.a027029.46","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.suppl_1.27"},{"key":"2018091410281030000_6.6.a027029.47","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1371-1375.2003"},{"key":"2018091410281030000_6.6.a027029.48","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(85)90052-6"},{"key":"2018091410281030000_6.6.a027029.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(82)80039-5"},{"key":"2018091410281030000_6.6.a027029.50","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.287"},{"key":"2018091410281030000_6.6.a027029.51","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm385"},{"key":"2018091410281030000_6.6.a027029.52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.00991.x"},{"key":"2018091410281030000_6.6.a027029.53","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000012"},{"key":"2018091410281030000_6.6.a027029.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.10.008"},{"key":"2018091410281030000_6.6.a027029.55","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1681-1688.2003"},{"key":"2018091410281030000_6.6.a027029.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2004.11.001"},{"key":"2018091410281030000_6.6.a027029.57","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/125.3.295"},{"key":"2018091410281030000_6.6.a027029.58","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3249-3256.2000"},{"key":"2018091410281030000_6.6.a027029.59","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq278"},{"key":"2018091410281030000_6.6.a027029.60","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq459"},{"key":"2018091410281030000_6.6.a027029.61","first-page":"106","article-title":"In vitro activity of carbapenems alone and in combination with amikacin against KPC-producing Klebsiella pneumoniae","volume":"3","year":"2011","journal-title":"J Clin Med Res"},{"key":"2018091410281030000_6.6.a027029.62","first-page":"391","article-title":"ANT(4\u2032)I: A new aminoglycoside nucleotidyltransferase found in \u201cstaphylococcus aureus.\u201d","volume":"127","year":"1976","journal-title":"Ann Microbiol (Paris)"},{"key":"2018091410281030000_6.6.a027029.63","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq408"},{"key":"2018091410281030000_6.6.a027029.64","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00125-4"},{"key":"2018091410281030000_6.6.a027029.65","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/135.Supplement_2.S316"},{"key":"2018091410281030000_6.6.a027029.66","doi-asserted-by":"publisher","DOI":"10.2741\/Macinga"},{"key":"2018091410281030000_6.6.a027029.67","doi-asserted-by":"publisher","DOI":"10.1021\/cr0301088"},{"key":"2018091410281030000_6.6.a027029.68","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3375-3380.2001"},{"key":"2018091410281030000_6.6.a027029.69","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.1.2.148"},{"key":"2018091410281030000_6.6.a027029.70","first-page":"139","article-title":"Arbekacin: Another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens","volume":"6","year":"2014","journal-title":"Clin Pharmacol"},{"key":"2018091410281030000_6.6.a027029.71","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1128\/AAC.43.4.727","article-title":"Aminoglycosides: Activity and resistance","volume":"43","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"2018091410281030000_6.6.a027029.72","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2012.0125"},{"key":"2018091410281030000_6.6.a027029.73","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-352"},{"key":"2018091410281030000_6.6.a027029.74","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383309"},{"key":"2018091410281030000_6.6.a027029.75","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.16.1252.30876"},{"key":"2018091410281030000_6.6.a027029.76","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr226"},{"key":"2018091410281030000_6.6.a027029.77","doi-asserted-by":"publisher","DOI":"10.1086\/500137"},{"key":"2018091410281030000_6.6.a027029.78","unstructured":"Nagabhushan T , Miller G , Weinstein M . 1982. Structure\u2013activity relationships in aminoglycoside-aminocyclitol antibiotics. In The aminoglycosides: Microbiology, clinical use and toxicology (ed. Whelton A , Neu HC ), pp. 3\u201327. Marcel Dekker, New York."},{"key":"2018091410281030000_6.6.a027029.79","doi-asserted-by":"publisher","DOI":"10.1042\/bj2280505"},{"key":"2018091410281030000_6.6.a027029.80","first-page":"674","article-title":"Implementation of a once-daily aminoglycoside program in a large community-teaching hospital","volume":"30","year":"1995","journal-title":"Hosp Pharm"},{"key":"2018091410281030000_6.6.a027029.81","doi-asserted-by":"publisher","DOI":"10.1038\/2081301a0"},{"key":"2018091410281030000_6.6.a027029.82","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/AAC.34.11.2164","article-title":"Gene homogeneity for aminoglycoside-modifying enzymes in Gram-positive cocci","volume":"34","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2018091410281030000_6.6.a027029.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.01.004"},{"key":"2018091410281030000_6.6.a027029.84","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13054-015-0967-9","article-title":"Selective decontamination and antibiotic resistance in ICUs","volume":"19","year":"2015","journal-title":"Crit Care"},{"key":"2018091410281030000_6.6.a027029.85","first-page":"305","article-title":"Efflux pump-mediated drug resistance in Burkholderia","volume":"6","year":"2015","journal-title":"Front Microbiol"},{"key":"2018091410281030000_6.6.a027029.86","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02571-13"},{"key":"2018091410281030000_6.6.a027029.87","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2197"},{"key":"2018091410281030000_6.6.a027029.88","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90137-6"},{"key":"2018091410281030000_6.6.a027029.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"2018091410281030000_6.6.a027029.90","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400104"},{"key":"2018091410281030000_6.6.a027029.91","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1128\/jb.175.20.6492-6498.1993","article-title":"Characterization and transcriptional regulation of the 2\u2032-N-acetyltransferase gene from Providencia stuartii","volume":"175","year":"1993","journal-title":"J Bacteriol"},{"key":"2018091410281030000_6.6.a027029.92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00007691-198503000-00003","article-title":"An overview of amikacin","volume":"7","year":"1985","journal-title":"Ther Drug Monit"},{"key":"2018091410281030000_6.6.a027029.93","doi-asserted-by":"publisher","DOI":"10.1038\/nm1347"},{"key":"2018091410281030000_6.6.a027029.94","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/bjs.9254","article-title":"Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery","volume":"100","year":"2013","journal-title":"Br J Surg"},{"key":"2018091410281030000_6.6.a027029.95","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.6.1754-1756.2000"},{"key":"2018091410281030000_6.6.a027029.96","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1128\/AAC.43.7.1549","article-title":"Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity","volume":"43","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"2018091410281030000_6.6.a027029.97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.007"},{"key":"2018091410281030000_6.6.a027029.98","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04839-14"},{"key":"2018091410281030000_6.6.a027029.99","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21521"},{"key":"2018091410281030000_6.6.a027029.100","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1128\/jb.174.11.3757-3765.1992","article-title":"rRNA gene organization in the Lyme disease spirochete, Borrelia burgdorferi","volume":"174","year":"1992","journal-title":"J Bacteriol"},{"key":"2018091410281030000_6.6.a027029.101","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/MMBR.57.1.138-163.1993","article-title":"Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes","volume":"57","year":"1993","journal-title":"Microbiol Rev"},{"key":"2018091410281030000_6.6.a027029.102","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.3.4.445"},{"key":"2018091410281030000_6.6.a027029.103","doi-asserted-by":"publisher","DOI":"10.1007\/BF00425725"},{"key":"2018091410281030000_6.6.a027029.104","doi-asserted-by":"publisher","DOI":"10.1177\/0009922810381425"},{"key":"2018091410281030000_6.6.a027029.105","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/MAJ.0b013e3182254bd6","article-title":"What would we do without metronidazole?","volume":"343","year":"2012","journal-title":"Am J Med Sci"},{"key":"2018091410281030000_6.6.a027029.106","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00016-09"},{"key":"2018091410281030000_6.6.a027029.107","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl225"},{"key":"2018091410281030000_6.6.a027029.108","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066536"},{"key":"2018091410281030000_6.6.a027029.109","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62050-8"},{"key":"2018091410281030000_6.6.a027029.110","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.6.807"},{"key":"2018091410281030000_6.6.a027029.111","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/MMBR.51.4.439-457.1987","article-title":"Bacterial uptake of aminoglycoside antibiotics","volume":"51","year":"1987","journal-title":"Microbiol Rev"},{"key":"2018091410281030000_6.6.a027029.112","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05041-11"},{"key":"2018091410281030000_6.6.a027029.113","doi-asserted-by":"publisher","DOI":"10.1007\/BF00425655"},{"key":"2018091410281030000_6.6.a027029.114","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.3.430-450.2003"},{"key":"2018091410281030000_6.6.a027029.115","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2012.05.001"},{"key":"2018091410281030000_6.6.a027029.116","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.178-184.2006"},{"key":"2018091410281030000_6.6.a027029.117","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00926-07"},{"key":"2018091410281030000_6.6.a027029.118","doi-asserted-by":"publisher","DOI":"10.2741\/Waters"},{"key":"2018091410281030000_6.6.a027029.119","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1128\/AAC.43.12.2975","article-title":"Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability","volume":"43","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"2018091410281030000_6.6.a027029.120","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3155"},{"key":"2018091410281030000_6.6.a027029.121","unstructured":"World Health Organization. 2011. Guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. World Health Organization, Geneva."},{"key":"2018091410281030000_6.6.a027029.122","doi-asserted-by":"publisher","DOI":"10.2741\/Wright"},{"key":"2018091410281030000_6.6.a027029.123","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.040924"},{"key":"2018091410281030000_6.6.a027029.124","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh455"},{"key":"2018091410281030000_6.6.a027029.125","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14959-8"},{"key":"2018091410281030000_6.6.a027029.126","doi-asserted-by":"publisher","DOI":"10.1177\/106002809102500210"}],"container-title":["Cold Spring Harbor Perspectives in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/cshperspect.a027029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T08:38:26Z","timestamp":1600677506000},"score":1,"resource":{"primary":{"URL":"http:\/\/perspectivesinmedicine.cshlp.org\/lookup\/doi\/10.1101\/cshperspect.a027029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":126,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,1]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1101\/cshperspect.a027029"],"URL":"https:\/\/doi.org\/10.1101\/cshperspect.a027029","relation":{},"ISSN":["2157-1422"],"issn-type":[{"value":"2157-1422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}