{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:00:19Z","timestamp":1793138419996,"version":"4.5.0"},"reference-count":71,"publisher":"Cold Spring Harbor Laboratory","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Perspect Med"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1101\/cshperspect.a031211","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T20:55:18Z","timestamp":1500065718000},"page":"a031211","source":"Crossref","is-referenced-by-count":310,"title":["Regulation of Bone Metabolism by Sex Steroids"],"prefix":"10.1101","volume":"8","author":[{"given":"Sundeep","family":"Khosla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"2018091410371303000_8.1.a031211.1","first-page":"298","article-title":"Post-menopausal osteoporosis","volume":"55","year":"1940","journal-title":"Trans Assoc Am Physicians"},{"key":"2018091410371303000_8.1.a031211.2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65910"},{"key":"2018091410371303000_8.1.a031211.3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2015"},{"key":"2018091410371303000_8.1.a031211.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390905"},{"key":"2018091410371303000_8.1.a031211.5","doi-asserted-by":"crossref","unstructured":"Bonnick SL . 1998. Skeletal anatomy in densitometry. In Bone densitometry in clinical practice (ed. Bonnick SL ), pp. 35\u201378. Humana, New York.","DOI":"10.1007\/978-1-60327-499-9_2"},{"key":"2018091410371303000_8.1.a031211.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.5.2309"},{"key":"2018091410371303000_8.1.a031211.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370204"},{"key":"2018091410371303000_8.1.a031211.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.13.1729"},{"key":"2018091410371303000_8.1.a031211.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0634-y"},{"key":"2018091410371303000_8.1.a031211.10","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070207"},{"key":"2018091410371303000_8.1.a031211.11","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081217"},{"key":"2018091410371303000_8.1.a031211.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1675-1"},{"key":"2018091410371303000_8.1.a031211.13","doi-asserted-by":"publisher","DOI":"10.1038\/nm809"},{"key":"2018091410371303000_8.1.a031211.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607948"},{"key":"2018091410371303000_8.1.a031211.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"2018091410371303000_8.1.a031211.16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bone.2016.12.004","article-title":"Hormomal and systemic regulation of sclerostin","volume":"96","year":"2017","journal-title":"Bone"},{"key":"2018091410371303000_8.1.a031211.17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317215"},{"key":"2018091410371303000_8.1.a031211.18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10942"},{"key":"2018091410371303000_8.1.a031211.19","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1210\/en.2016-1181","article-title":"Female mice lacking estrogen receptor \u03b1 in hypothalamic pro-opimelanocortin (POMC) meurons display enhanced estrogenic response on cortical bone mass","volume":"157","year":"2016","journal-title":"Endocrinology"},{"key":"2018091410371303000_8.1.a031211.20","doi-asserted-by":"crossref","first-page":"e0138347","DOI":"10.1371\/journal.pone.0138347","article-title":"Effects of age and estrogen on skeletal gene expression in humans as assessed by RNA sequencing","volume":"10","year":"2015","journal-title":"PLoS ONE"},{"key":"2018091410371303000_8.1.a031211.21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84137"},{"key":"2018091410371303000_8.1.a031211.22","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1210\/jc.2013-3249","article-title":"Effects of estrogen on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in postmenopausal women","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2018091410371303000_8.1.a031211.23","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.12.5566"},{"key":"2018091410371303000_8.1.a031211.24","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215610589"},{"key":"2018091410371303000_8.1.a031211.25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314324200"},{"key":"2018091410371303000_8.1.a031211.26","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt046"},{"key":"2018091410371303000_8.1.a031211.27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533500100"},{"key":"2018091410371303000_8.1.a031211.28","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0014"},{"key":"2018091410371303000_8.1.a031211.29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jbmr.1541","article-title":"Odanacatib: Location and timing are everything","volume":"27","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2018091410371303000_8.1.a031211.30","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2529"},{"key":"2018091410371303000_8.1.a031211.31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2266"},{"key":"2018091410371303000_8.1.a031211.32","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0002"},{"key":"2018091410371303000_8.1.a031211.33","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.262"},{"key":"2018091410371303000_8.1.a031211.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.12.005"},{"key":"2018091410371303000_8.1.a031211.35","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060726"},{"key":"2018091410371303000_8.1.a031211.36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86062"},{"key":"2018091410371303000_8.1.a031211.37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-213587"},{"key":"2018091410371303000_8.1.a031211.38","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0354"},{"key":"2018091410371303000_8.1.a031211.39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117424"},{"key":"2018091410371303000_8.1.a031211.40","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2082"},{"key":"2018091410371303000_8.1.a031211.41","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1089"},{"key":"2018091410371303000_8.1.a031211.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.04.015"},{"key":"2018091410371303000_8.1.a031211.43","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.128"},{"key":"2018091410371303000_8.1.a031211.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.025"},{"key":"2018091410371303000_8.1.a031211.45","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2452"},{"key":"2018091410371303000_8.1.a031211.46","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2723"},{"key":"2018091410371303000_8.1.a031211.47","doi-asserted-by":"crossref","first-page":"e0140775","DOI":"10.1371\/journal.pone.0140775","article-title":"Missense mutations in LRP5 associated with high bone mass protect the mouse skeleton from discuse and ovariectomy-induced osteopenis","volume":"10","year":"2015","journal-title":"PLos ONE"},{"key":"2018091410371303000_8.1.a031211.48","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.061117"},{"key":"2018091410371303000_8.1.a031211.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111436109"},{"key":"2018091410371303000_8.1.a031211.50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.377945"},{"key":"2018091410371303000_8.1.a031211.51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6613"},{"key":"2018091410371303000_8.1.a031211.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5227"},{"key":"2018091410371303000_8.1.a031211.53","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1500"},{"key":"2018091410371303000_8.1.a031211.54","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-11-2-386"},{"key":"2018091410371303000_8.1.a031211.55","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.37"},{"key":"2018091410371303000_8.1.a031211.56","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.3.279"},{"key":"2018091410371303000_8.1.a031211.57","first-page":"185","article-title":"Aromatase expression in health and disease","volume":"52","year":"1997","journal-title":"Recent Prog Horm Res"},{"key":"2018091410371303000_8.1.a031211.58","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00643-3"},{"key":"2018091410371303000_8.1.a031211.59","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1713"},{"key":"2018091410371303000_8.1.a031211.60","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410203311604"},{"key":"2018091410371303000_8.1.a031211.61","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2397"},{"key":"2018091410371303000_8.1.a031211.62","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4113"},{"key":"2018091410371303000_8.1.a031211.63","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-3-523"},{"key":"2018091410371303000_8.1.a031211.64","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.129"},{"key":"2018091410371303000_8.1.a031211.65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409857112"},{"key":"2018091410371303000_8.1.a031211.66","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2485"},{"key":"2018091410371303000_8.1.a031211.67","first-page":"560","article-title":"The effects of aging and sex steroid deficiency on the murine skeleton are independent and mechanistically distinct","volume":"32","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2018091410371303000_8.1.a031211.68","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28550"},{"key":"2018091410371303000_8.1.a031211.69","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6730"},{"key":"2018091410371303000_8.1.a031211.70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220811110"},{"key":"2018091410371303000_8.1.a031211.71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212474399"}],"container-title":["Cold Spring Harbor Perspectives in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/cshperspect.a031211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T05:33:40Z","timestamp":1569821620000},"score":1,"resource":{"primary":{"URL":"http:\/\/perspectivesinmedicine.cshlp.org\/lookup\/doi\/10.1101\/cshperspect.a031211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,2]]},"published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1101\/cshperspect.a031211"],"URL":"https:\/\/doi.org\/10.1101\/cshperspect.a031211","relation":{},"ISSN":["2157-1422"],"issn-type":[{"value":"2157-1422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]}}}