{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:26:29Z","timestamp":1779207989960,"version":"3.51.4"},"reference-count":163,"publisher":"Cold Spring Harbor Laboratory","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Perspect Med"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1101\/cshperspect.a039263","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T20:45:25Z","timestamp":1578948325000},"page":"a039263","source":"Crossref","is-referenced-by-count":15,"title":["Medications Development for Treatment of Opioid Use Disorder"],"prefix":"10.1101","volume":"11","author":[{"given":"E. Andrew","family":"Townsend","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Stevens","family":"Negus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-5246","authenticated-orcid":false,"given":"Matthew L.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"2021010407451160000_11.1.a039263.1","doi-asserted-by":"publisher","DOI":"10.1038\/276186a0"},{"key":"2021010407451160000_11.1.a039263.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.04.005"},{"key":"2021010407451160000_11.1.a039263.3","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12443"},{"key":"2021010407451160000_11.1.a039263.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3719-7"},{"key":"2021010407451160000_11.1.a039263.5","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116689257"},{"key":"2021010407451160000_11.1.a039263.6","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders, 5th ed. American Psychiatric Association, Arlington, VA.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"2021010407451160000_11.1.a039263.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00099-1"},{"key":"2021010407451160000_11.1.a039263.8","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.63"},{"key":"2021010407451160000_11.1.a039263.9","first-page":"281768","article-title":"Preclinical determinants of drug choice under concurrent schedules of drug self-administration","volume":"2012","year":"2012","journal-title":"Adv Pharmacol Sci"},{"key":"2021010407451160000_11.1.a039263.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.11.002"},{"key":"2021010407451160000_11.1.a039263.11","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.259"},{"key":"2021010407451160000_11.1.a039263.12","doi-asserted-by":"publisher","DOI":"10.1007\/s40501-015-0042-9"},{"key":"2021010407451160000_11.1.a039263.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.08.001"},{"key":"2021010407451160000_11.1.a039263.14","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0336-5"},{"key":"2021010407451160000_11.1.a039263.15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b01296"},{"key":"2021010407451160000_11.1.a039263.16","doi-asserted-by":"publisher","DOI":"10.1007\/s002100000244"},{"key":"2021010407451160000_11.1.a039263.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00061-8"},{"key":"2021010407451160000_11.1.a039263.18","doi-asserted-by":"publisher","DOI":"10.1038\/252708a0"},{"key":"2021010407451160000_11.1.a039263.19","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803582469"},{"key":"2021010407451160000_11.1.a039263.20","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.013904"},{"key":"2021010407451160000_11.1.a039263.21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b03334"},{"key":"2021010407451160000_11.1.a039263.22","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051134"},{"key":"2021010407451160000_11.1.a039263.23","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2014.1001098"},{"key":"2021010407451160000_11.1.a039263.24","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12417"},{"key":"2021010407451160000_11.1.a039263.25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011592"},{"key":"2021010407451160000_11.1.a039263.26","doi-asserted-by":"publisher","DOI":"10.1080\/09595230600944487"},{"key":"2021010407451160000_11.1.a039263.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.01.010"},{"key":"2021010407451160000_11.1.a039263.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01572-0"},{"key":"2021010407451160000_11.1.a039263.29","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000623"},{"key":"2021010407451160000_11.1.a039263.30","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0023-6"},{"key":"2021010407451160000_11.1.a039263.31","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.8.1285"},{"key":"2021010407451160000_11.1.a039263.32","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.246439"},{"key":"2021010407451160000_11.1.a039263.33","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39945"},{"key":"2021010407451160000_11.1.a039263.34","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011668"},{"key":"2021010407451160000_11.1.a039263.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.05.021"},{"key":"2021010407451160000_11.1.a039263.36","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.201616"},{"key":"2021010407451160000_11.1.a039263.37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433012"},{"key":"2021010407451160000_11.1.a039263.38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5274"},{"key":"2021010407451160000_11.1.a039263.39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605295113"},{"key":"2021010407451160000_11.1.a039263.40","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar3483"},{"key":"2021010407451160000_11.1.a039263.41","doi-asserted-by":"publisher","DOI":"10.1038\/ajgsup.2014.7"},{"key":"2021010407451160000_11.1.a039263.42","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6501e1"},{"key":"2021010407451160000_11.1.a039263.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.09.008"},{"key":"2021010407451160000_11.1.a039263.44","doi-asserted-by":"publisher","DOI":"10.1159\/000324065"},{"key":"2021010407451160000_11.1.a039263.45","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0091-3057(85)90079-6","article-title":"Concurrent heroin self-administration and intracranial self-stimulation in rats","volume":"23","year":"1985","journal-title":"Pharmacol Biochem Behav"},{"key":"2021010407451160000_11.1.a039263.46","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000995"},{"key":"2021010407451160000_11.1.a039263.47","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.136.1.100"},{"key":"2021010407451160000_11.1.a039263.48","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.4.713"},{"key":"2021010407451160000_11.1.a039263.49","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200006000-00003"},{"key":"2021010407451160000_11.1.a039263.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.03.007"},{"key":"2021010407451160000_11.1.a039263.51","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.drugalcdep.2009.04.006","article-title":"Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of alternative reinforcer magnitude and post-session drug supply","volume":"104","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"2021010407451160000_11.1.a039263.52","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-001-0975-0"},{"key":"2021010407451160000_11.1.a039263.53","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300251"},{"key":"2021010407451160000_11.1.a039263.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.07.035"},{"key":"2021010407451160000_11.1.a039263.55","first-page":"357","article-title":"Discrete-trial choice procedure: effects of naloxone and methadone on choice between food and heroin","volume":"27","year":"1975","journal-title":"Pharmacol Rev"},{"key":"2021010407451160000_11.1.a039263.56","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1981.35-335"},{"key":"2021010407451160000_11.1.a039263.57","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000277"},{"key":"2021010407451160000_11.1.a039263.58","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1079-x"},{"key":"2021010407451160000_11.1.a039263.59","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12358"},{"key":"2021010407451160000_11.1.a039263.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.11.014"},{"key":"2021010407451160000_11.1.a039263.61","doi-asserted-by":"crossref","unstructured":"Heyman GM . 2009. Addiction: a disorder of choice. Harvard University Press, Cambridge, MA.","DOI":"10.2307\/j.ctvjf9xd9"},{"key":"2021010407451160000_11.1.a039263.62","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4734-2"},{"key":"2021010407451160000_11.1.a039263.63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.5.3097"},{"key":"2021010407451160000_11.1.a039263.64","doi-asserted-by":"publisher","DOI":"10.1111\/add.14180"},{"key":"2021010407451160000_11.1.a039263.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.12.026"},{"key":"2021010407451160000_11.1.a039263.66","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790340041006"},{"key":"2021010407451160000_11.1.a039263.67","first-page":"43","article-title":"A summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys","volume":"30","year":"1978","journal-title":"Bull Narc"},{"key":"2021010407451160000_11.1.a039263.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.12.024"},{"key":"2021010407451160000_11.1.a039263.69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992"},{"key":"2021010407451160000_11.1.a039263.70","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050049"},{"key":"2021010407451160000_11.1.a039263.71","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000555"},{"key":"2021010407451160000_11.1.a039263.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.06.010"},{"key":"2021010407451160000_11.1.a039263.73","unstructured":"Katz JL . 1989. Drugs as reinforcers: pharmacological and behavioural factors. In The neuropharmacological basis of reward (ed. Liebman JM , Cooper SJ ), pp. 164\u2013213. Clarendon Press, Oxford."},{"key":"2021010407451160000_11.1.a039263.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)89032-X"},{"key":"2021010407451160000_11.1.a039263.75","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.099770"},{"key":"2021010407451160000_11.1.a039263.76","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2407"},{"key":"2021010407451160000_11.1.a039263.77","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025799"},{"key":"2021010407451160000_11.1.a039263.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.05.012"},{"key":"2021010407451160000_11.1.a039263.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.05.023"},{"key":"2021010407451160000_11.1.a039263.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.04.003"},{"key":"2021010407451160000_11.1.a039263.81","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14081014"},{"key":"2021010407451160000_11.1.a039263.82","doi-asserted-by":"publisher","DOI":"10.1080\/10550881003684798"},{"key":"2021010407451160000_11.1.a039263.83","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4368-9"},{"key":"2021010407451160000_11.1.a039263.84","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2431"},{"key":"2021010407451160000_11.1.a039263.85","first-page":"1207","article-title":"Duration of occupancy of opiate receptors by naltrexone","volume":"29","year":"1988","journal-title":"J Nucl Med"},{"key":"2021010407451160000_11.1.a039263.86","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.17"},{"key":"2021010407451160000_11.1.a039263.87","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.05.022"},{"key":"2021010407451160000_11.1.a039263.88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2005.01154.x"},{"key":"2021010407451160000_11.1.a039263.89","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.213694"},{"key":"2021010407451160000_11.1.a039263.90","doi-asserted-by":"publisher","DOI":"10.2165\/11587790-000000000-00000"},{"key":"2021010407451160000_11.1.a039263.91","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.01.001"},{"key":"2021010407451160000_11.1.a039263.92","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.252353"},{"key":"2021010407451160000_11.1.a039263.93","first-page":"CD002207","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","volume":"2004","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2021010407451160000_11.1.a039263.94","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.072686"},{"key":"2021010407451160000_11.1.a039263.95","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(95)00274-H"},{"key":"2021010407451160000_11.1.a039263.96","first-page":"30","article-title":"Buprenorphine effects on human heroin self-administration: an operant analysis","volume":"223","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"2021010407451160000_11.1.a039263.97","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/npp.2017.70","article-title":"Effects of ibudilast on the subjective, reinforcing, and analgesic effects of oxycodone in recently detoxified adults with opioid dependence","volume":"42","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2021010407451160000_11.1.a039263.98","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000200"},{"key":"2021010407451160000_11.1.a039263.99","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0227"},{"key":"2021010407451160000_11.1.a039263.100","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245115"},{"key":"2021010407451160000_11.1.a039263.101","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300096"},{"key":"2021010407451160000_11.1.a039263.102","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.095380"},{"key":"2021010407451160000_11.1.a039263.103","doi-asserted-by":"crossref","unstructured":"Negus SS . 2009. Opioid antagonist effects in animal models related to opioid abuse: drug discrimination and drug self-administration. In Opioid receptors and antagonists: from bench to clinic (ed. Dean R , Bilsky EJ , Negus SS ), pp. 221\u2013226. Humana, New York.","DOI":"10.1007\/978-1-59745-197-0_11"},{"key":"2021010407451160000_11.1.a039263.104","doi-asserted-by":"crossref","unstructured":"Negus SS , Banks ML . 2011. Making the right choice: lessons from drug discrimination for research on drug reinforcement and drug self-administration. In Drug discrimination: applications to medicinal chemistry and drug studies (ed. Glennon RA , Young R ), pp. 361\u2013388. Wiley, Hoboken, NJ.","DOI":"10.1002\/9781118023150.ch11"},{"key":"2021010407451160000_11.1.a039263.105","doi-asserted-by":"crossref","unstructured":"Negus SS , Banks ML . 2013. Medications development for opioid abuse. In Addiction (ed. Pierce RC , Kenny PJ ). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.","DOI":"10.1101\/cshperspect.a012104"},{"key":"2021010407451160000_11.1.a039263.106","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2017.04.006"},{"key":"2021010407451160000_11.1.a039263.107","unstructured":"Negus SS , Dykstra LA . 1989. Neural substrates of the reinforcing properties of opioid analgesics. In Focus on biochemistry and physiology of substance abuse (ed. Watson RR ), pp. 211\u2013242. CRC, Boca Raton, FL."},{"key":"2021010407451160000_11.1.a039263.108","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.127"},{"key":"2021010407451160000_11.1.a039263.109","unstructured":"Negus SS , Woods JH . 1995. Reinforcing effects, discriminative stimulus effects, and physical dependence liability of buprenorphine. In Buprenorphine: combatting drug abuse with a unique opioid (ed. Cowan A , Lewis JW ), pp. 71\u2013101. Wiley, New York."},{"key":"2021010407451160000_11.1.a039263.110","first-page":"896","article-title":"Effects of opioid agonists selective for mu, kappa and delta opioid receptors on schedule-controlled responding in rhesus monkeys: antagonism by quadazocine","volume":"267","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"2021010407451160000_11.1.a039263.111","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00742"},{"key":"2021010407451160000_11.1.a039263.112","doi-asserted-by":"publisher","DOI":"10.1111\/add.14735"},{"key":"2021010407451160000_11.1.a039263.113","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.012"},{"key":"2021010407451160000_11.1.a039263.114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01415.x"},{"key":"2021010407451160000_11.1.a039263.115","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1007\/s00213-017-4726-2","article-title":"Choice between delayed food and immediate opioids in rats: treatment effects and individual differences","volume":"234","year":"2017","journal-title":"Psychopharmacology"},{"key":"2021010407451160000_11.1.a039263.116","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618796748"},{"key":"2021010407451160000_11.1.a039263.117","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.02.010"},{"key":"2021010407451160000_11.1.a039263.118","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.117"},{"key":"2021010407451160000_11.1.a039263.119","first-page":"CD007522","article-title":"Pharmacological therapies for management of opium withdrawal","volume":"6","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2021010407451160000_11.1.a039263.120","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0292-5"},{"key":"2021010407451160000_11.1.a039263.121","unstructured":"SAMHSA. 2018. Medications for opioid use disorder. Treatment Improvement Protocol 63, HHS Publication No. (SMA) 18-5063FULLDOC, Rockville, MD."},{"key":"2021010407451160000_11.1.a039263.122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.035"},{"key":"2021010407451160000_11.1.a039263.123","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2018.3.E193"},{"key":"2021010407451160000_11.1.a039263.124","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.06.006"},{"key":"2021010407451160000_11.1.a039263.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.01.020"},{"key":"2021010407451160000_11.1.a039263.126","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00213-016-4429-0","article-title":"Choice between delayed food and immediate oxycodone in rats","volume":"233","year":"2016","journal-title":"Psychopharmacology"},{"key":"2021010407451160000_11.1.a039263.127","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.1103"},{"key":"2021010407451160000_11.1.a039263.128","first-page":"496","article-title":"Signal transduction correlates of \u03bc opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP \u03b3 S binding in mMOR-CHO cells and rat thalamus","volume":"285","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"2021010407451160000_11.1.a039263.129","unstructured":"Sevarino K , Kosten T . 2007. Naltrexone for initiation and maintenance of opiate abstinence. In Opioid receptors and antagonists: from bench to clinic (ed. Dean R , Bilsky E , Negus S ). Humana, New York."},{"key":"2021010407451160000_11.1.a039263.130","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-05-01957.1996"},{"key":"2021010407451160000_11.1.a039263.131","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S137952"},{"key":"2021010407451160000_11.1.a039263.132","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4840-9"},{"key":"2021010407451160000_11.1.a039263.133","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.06.011"},{"key":"2021010407451160000_11.1.a039263.134","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00252-9"},{"key":"2021010407451160000_11.1.a039263.135","first-page":"5","article-title":"Morphine addiction in chimpanzees","volume":"15","year":"1940","journal-title":"Comp Psychol Mono"},{"key":"2021010407451160000_11.1.a039263.136","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01427"},{"key":"2021010407451160000_11.1.a039263.137","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0509-x"},{"key":"2021010407451160000_11.1.a039263.138","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107730"},{"key":"2021010407451160000_11.1.a039263.139","doi-asserted-by":"publisher","DOI":"10.1007\/BF00413045"},{"key":"2021010407451160000_11.1.a039263.140","doi-asserted-by":"publisher","DOI":"10.1002\/jeab.15"},{"key":"2021010407451160000_11.1.a039263.141","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.241141"},{"key":"2021010407451160000_11.1.a039263.142","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0385-9"},{"key":"2021010407451160000_11.1.a039263.143","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0356-1"},{"key":"2021010407451160000_11.1.a039263.144","doi-asserted-by":"publisher","DOI":"10.1101\/705020"},{"key":"2021010407451160000_11.1.a039263.145","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0418-4"},{"key":"2021010407451160000_11.1.a039263.146","first-page":"62","article-title":"Methylnaltrexone: peripherally acting mu-opioid receptor antagonist","volume":"10","year":"2019","journal-title":"J Adv Pract Oncol"},{"key":"2021010407451160000_11.1.a039263.147","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6451-9_10"},{"key":"2021010407451160000_11.1.a039263.148","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0246-6"},{"key":"2021010407451160000_11.1.a039263.149","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.05.018"},{"key":"2021010407451160000_11.1.a039263.150","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00104-7"},{"key":"2021010407451160000_11.1.a039263.151","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1901\/jeab.2011.95-75","article-title":"Effects of daily morphine administration and deprivation on choice and demand for remifentanil and cocaine in rhesus monkeys","volume":"95","year":"2011","journal-title":"J Exp Anal Behav"},{"key":"2021010407451160000_11.1.a039263.152","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12911"},{"key":"2021010407451160000_11.1.a039263.153","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1825-8"},{"key":"2021010407451160000_11.1.a039263.154","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301440"},{"key":"2021010407451160000_11.1.a039263.155","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.299"},{"key":"2021010407451160000_11.1.a039263.156","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01267-5"},{"key":"2021010407451160000_11.1.a039263.157","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08862"},{"key":"2021010407451160000_11.1.a039263.158","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(77)90248-9"},{"key":"2021010407451160000_11.1.a039263.159","first-page":"179","article-title":"Drug dependence studies in laboratory animals","volume":"19","year":"1978","journal-title":"NIDA Res Monogr"},{"key":"2021010407451160000_11.1.a039263.160","unstructured":"Young AM , Herling S . 1986. Drugs as reinforcers: studies in laboratory animals. In Behavioral analysis of drug dependence (ed. Goldberg SR , Stolerman IP ), pp. 9\u201367. Academic, Orlando, FL."},{"key":"2021010407451160000_11.1.a039263.161","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.08.002"},{"key":"2021010407451160000_11.1.a039263.162","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00110"},{"key":"2021010407451160000_11.1.a039263.163","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050185"}],"container-title":["Cold Spring Harbor Perspectives in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/cshperspect.a039263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T17:59:43Z","timestamp":1609783183000},"score":1,"resource":{"primary":{"URL":"http:\/\/perspectivesinmedicine.cshlp.org\/lookup\/doi\/10.1101\/cshperspect.a039263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,13]]},"references-count":163,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,4]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1101\/cshperspect.a039263"],"URL":"https:\/\/doi.org\/10.1101\/cshperspect.a039263","relation":{},"ISSN":["2157-1422"],"issn-type":[{"value":"2157-1422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,13]]}}}