{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:41:13Z","timestamp":1790880073786,"version":"4.1.0"},"reference-count":33,"publisher":"Cold Spring Harbor Laboratory","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:p>Left-sided expression of<jats:italic>Nodal<\/jats:italic>in the lateral plate mesoderm is a conserved feature necessary for the establishment of normal left\u2013right asymmetry during vertebrate embryogenesis. By using gain- and loss-of-function experiments in zebrafish and mouse, we show that the activity of the Notch pathway is necessary and sufficient for<jats:italic>Nodal<\/jats:italic>expression around the node, and for proper left\u2013right determination. We identify Notch-responsive elements in the<jats:italic>Nodal<\/jats:italic>promoter, and unveil a direct relationship between Notch activity and<jats:italic>Nodal<\/jats:italic>expression around the node. Our findings provide evidence for a mechanism involving Notch activity that translates an initial symmetry-breaking event into asymmetric gene expression.<\/jats:p>","DOI":"10.1101\/gad.1084403","type":"journal-article","created":{"date-parts":[[2003,5,16]],"date-time":"2003-05-16T21:20:03Z","timestamp":1053120003000},"page":"1213-1218","source":"Crossref","is-referenced-by-count":162,"title":["Notch activity induces<i>Nodal<\/i>expression and mediates the establishment of left\u2013right asymmetry in vertebrate embryos"],"prefix":"10.1101","volume":"17","author":[{"given":"\u00c1ngel","family":"Raya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Rodr\u0131\u0301guez-Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"B\u00fcscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Koth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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