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Beginning at the same stage, the basic helix-loop-helix (bHLH) factor gene eHand was expressed in a strikingly left-dominant pattern in myocardium, reflecting an intrinsic molecular asymmetry. In hearts of embryos lacking the homeobox gene Nkx2-5, which do not loop, left-sided eHand expression was abolished. However, expression was unaffected in Sc1-\/- hearts that loop poorly because of hematopoietic insufficiency, and was right-sided in hearts of inv\/inv embryos that display situs inversus. The data predict that eHand expression is enhanced in descendants of the left heart progenitor pool as one response to inductive signaling from the L\/R axial system, and that eHand controls intrinsic morphogenetic pathways essential for looping. One aspect of the intrinsic response to L\/R information falls under Nkx2-5 homeobox control.<\/jats:p>","DOI":"10.1101\/gad.11.11.1357","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"1357-1369","source":"Crossref","is-referenced-by-count":268,"title":["Homeodomain factor Nkx2-5 controls left\/right asymmetric expression of bHLH gene eHand during murine heart development."],"prefix":"10.1101","volume":"11","author":[{"given":"C","family":"Biben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1997,6,1]]},"reference":[{"key":"2021111418451031000_11.11.1357.1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1242\/dev.118.3.719","article-title":"The gene tinman is required for specification of the heart and visceral muscles in Drosophila.","volume":"118","year":"1993","journal-title":"Development"},{"key":"2021111418451031000_11.11.1357.2","doi-asserted-by":"publisher","DOI":"10.1016\/1050-1738(94)00032-Q"},{"key":"2021111418451031000_11.11.1357.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00575837"},{"key":"2021111418451031000_11.11.1357.4","doi-asserted-by":"publisher","DOI":"10.1016\/1058-9813(96)00171-3"},{"key":"2021111418451031000_11.11.1357.5","doi-asserted-by":"crossref","unstructured":"Burn, J. 1991. 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