{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:16:28Z","timestamp":1793229388659,"version":"4.5.0"},"reference-count":28,"publisher":"Cold Spring Harbor Laboratory","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>\n                    Expression of AP-2 transcription factors has been detected previously in embryonic renal tissues. We show here that\n                    <jats:italic>AP-2\u03b2<\/jats:italic>\n                    \u2212\/\u2212 mice complete embryonic development and die at postnatal days 1 and 2 because of polycystic kidney disease. Analyses of kidney development revealed that induction of epithelial conversion, mesenchyme condensation, and further glomerular and tubular differentiation occur normally in AP-2\u03b2-deficient mice. At the end of embryonic development expression of\n                    <jats:italic>\n                      bcl-X\n                      <jats:sub>L<\/jats:sub>\n                      , bcl-w,\n                    <\/jats:italic>\n                    and\n                    <jats:italic>bcl-2<\/jats:italic>\n                    is down-regulated in parallel to massive apoptotic death of collecting duct and distal tubular epithelia. Addressing the molecular mechanism we show that transfection of AP-2 into cell lines in vitro strongly suppresses c-\n                    <jats:italic>myc<\/jats:italic>\n                    -induced apoptosis pointing to a function of AP-2 in programming cell survival during embryogenesis. The position of the human\n                    <jats:italic>AP-2\u03b2<\/jats:italic>\n                    gene was identified at chromosome 6p12\u2013p21.1, within a region that has been mapped for autosomal recessive polycystic kidney disease (ARPKD). Sequence analyses of ARPKD patients and linkage analyses using intragenic polymorphic markers indicate that the AP-2\u03b2 gene is located in close proximity to but distinct from the ARPKD gene.\n                  <\/jats:p>","DOI":"10.1101\/gad.11.15.1938","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T17:15:26Z","timestamp":1203527726000},"page":"1938-1948","source":"Crossref","is-referenced-by-count":230,"title":["Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor\u2009AP-2\u03b2"],"prefix":"10.1101","volume":"11","author":[{"given":"Markus","family":"Moser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Pscherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabi","family":"M\u00fccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Zerres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Dixkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Guay-Woodford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"F\u00e4ssler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"2021111418462436000_11.15.1938.1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.8.1413"},{"key":"2021111418462436000_11.15.1938.2","doi-asserted-by":"publisher","DOI":"10.1038\/359552a0"},{"key":"2021111418462436000_11.15.1938.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.744"},{"key":"2021111418462436000_11.15.1938.4","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(95)00463-7"},{"key":"2021111418462436000_11.15.1938.5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1242\/dev.118.3.777","article-title":"Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor.","volume":"118","author":"Coles","year":"1993","journal-title":"Development"},{"key":"2021111418462436000_11.15.1938.6","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/j.1460-2075.1995.tb07137.x","article-title":"Transcription factor AP-2 negatively regulates gene activation by myc.","volume":"14","author":"Gaubatz","year":"1995","journal-title":"EMBO J."},{"key":"2021111418462436000_11.15.1938.7","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.493"},{"key":"2021111418462436000_11.15.1938.8","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1242\/dev.120.10.3033","article-title":"Bcl-XL is the major bcl-X mRNA form expressed during murine development and ist product localizes to mitochondria.","volume":"120","author":"Gonzalez-Garcia","year":"1994","journal-title":"Development"},{"key":"2021111418462436000_11.15.1938.9","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.11.1258"},{"key":"2021111418462436000_11.15.1938.10","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4671"},{"key":"2021111418462436000_11.15.1938.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.2294592"},{"key":"2021111418462436000_11.15.1938.12","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.1.105"},{"key":"2021111418462436000_11.15.1938.13","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1242\/dev.121.9.2779","article-title":"Molecular cloning and characterization of a second AP-2 transcription activator gene, AP-2\u03b2.","volume":"121","author":"Moser","year":"1995","journal-title":"Development"},{"key":"2021111418462436000_11.15.1938.14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<115::AID-AJA11>3.0.CO;2-5"},{"key":"2021111418462436000_11.15.1938.15","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0184"},{"key":"2021111418462436000_11.15.1938.16","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5295.2082"},{"key":"2021111418462436000_11.15.1938.17","unstructured":"Sambrook J. 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