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Cell proliferation defects were observed in <jats:italic>Ovca1<\/jats:italic> mutant mouse embryonic fibroblasts (MEFs). <jats:italic>p53<\/jats:italic> deficiency can rescue these <jats:italic>Ovca1<\/jats:italic> mutant MEF proliferation defects and partially rescue <jats:italic>Ovca1<\/jats:italic> mutant embryonic phenotypes. Furthermore, <jats:italic>Ovca1; p53<\/jats:italic> double heterozygotes developed tumors quicker than <jats:italic>p53<\/jats:italic> heterozygotes and with an increased carcinoma incidence. Multiple tumor burden in <jats:italic>Ovca1<\/jats:italic> heterozygotes that were also <jats:italic>p53<\/jats:italic> deficient was significantly higher than in <jats:italic>p53<\/jats:italic> homozygous mutants. These in vivo findings demonstrate that <jats:italic>Ovca1<\/jats:italic> is a tumor suppressor that can modify <jats:italic>p53<\/jats:italic>-induced tumorigenesis and suggest that it acts as a positive regulator for cell cycle progression. The close linkage of <jats:italic>OVCA1<\/jats:italic> and <jats:italic>p53<\/jats:italic> on human Chromosome 17 suggests that coordinated loss may be an important mechanism for the evolution of ovarian, breast, and other tumor phenotypes.<\/jats:p>","DOI":"10.1101\/gad.1162204","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T01:34:05Z","timestamp":1075167245000},"page":"320-332","source":"Crossref","is-referenced-by-count":99,"title":["<i>Ovca1<\/i> regulates cell proliferation, embryonic development, and tumorigenesis"],"prefix":"10.1101","volume":"18","author":[{"given":"Chun-Ming","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Behringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2004,1,26]]},"reference":[{"key":"2021111519341283000_18.3.320.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02751-1"},{"key":"2021111519341283000_18.3.320.2","doi-asserted-by":"crossref","unstructured":"Bast R.C Jr . and Mills, G.B. 2000. 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