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We also provide evidence that IPF1\/PDX1 regulates the expression of Glut2 in a dosage-dependent manner suggesting that lowered IPF1\/PDX1 activity may contribute to the development of type II diabetes by causing impaired expression of both Glut2 and insulin.<\/jats:p>","DOI":"10.1101\/gad.12.12.1763","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:52:17Z","timestamp":1203547937000},"page":"1763-1768","source":"Crossref","is-referenced-by-count":798,"title":["\u03b2-Cell-specific inactivation of the mouse<i>Ipf1\/Pdx1<\/i> gene results in loss of the \u03b2-cell phenotype and maturity onset\u2009diabetes"],"prefix":"10.1101","volume":"12","author":[{"given":"Ulf","family":"Ahlgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Simu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Edlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1998,6,15]]},"reference":[{"key":"2021111418543462000_12.12.1763.1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/dev.122.5.1409","article-title":"Arrested development of the pancreas in IPF1\/PDX1 deficient mice reveals that the pancreatic mesenchyme develops independently of the pancreatic epithelium.","volume":"122","author":"Ahlgren","year":"1996","journal-title":"Development"},{"key":"2021111418543462000_12.12.1763.2","doi-asserted-by":"publisher","DOI":"10.1038\/385257a0"},{"key":"2021111418543462000_12.12.1763.3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.37.21464"},{"key":"2021111418543462000_12.12.1763.4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.9.2025"},{"key":"2021111418543462000_12.12.1763.5","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.122.9.2895","article-title":"Cadherins regulate aggregation of pancreatic \u03b2-cells in vivo.","volume":"122","author":"Dahl","year":"1996","journal-title":"Development"},{"key":"2021111418543462000_12.12.1763.6","doi-asserted-by":"publisher","DOI":"10.1038\/356162a0"},{"key":"2021111418543462000_12.12.1763.7","unstructured":"Githens S. 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