{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:04:11Z","timestamp":1791349451508,"version":"4.3.1"},"reference-count":57,"publisher":"Cold Spring Harbor Laboratory","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>The<jats:italic>bcl-6<\/jats:italic>proto-oncogene encodes a POZ\/zinc finger transcriptional repressor expressed in germinal center (GC) B and T cells and required for GC formation and antibody affinity maturation. Deregulation of<jats:italic>bcl-6<\/jats:italic>expression by chromosomal rearrangements and point mutations of the<jats:italic>bcl-6<\/jats:italic>promoter region are implicated in the pathogenesis of B-cell lymphoma. The signals regulating<jats:italic>bcl-6<\/jats:italic>expression are not known. Here we show that antigen receptor activation leads to BCL-6 phosphorylation by mitogen-activated protein kinase (MAPK). Phosphorylation, in turn, targets BCL-6 for rapid degradation by the ubiquitin\/proteasome pathway. These findings indicate that BCL-6 expression is directly controlled by the antigen receptor via MAPK activation. This signaling pathway may be crucial for the control of B-cell differentiation and antibody response and has implications for the regulation of other POZ\/zinc finger transcription factors in other tissues.<\/jats:p>","DOI":"10.1101\/gad.12.13.1953","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:52:17Z","timestamp":1203547937000},"page":"1953-1961","source":"Crossref","is-referenced-by-count":262,"title":["Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription\u2009factor"],"prefix":"10.1101","volume":"12","author":[{"given":"Huifeng","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihui H.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2021111418545546000_12.13.1953.1","first-page":"1193","article-title":"The BTB\/POZ domain: A new protein-protein interaction motif common to DNA- and actin-binding proteins.","volume":"6","author":"Albagli","year":"1995","journal-title":"Cell Growth & Differ."},{"key":"2021111418545546000_12.13.1953.2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.125"},{"key":"2021111418545546000_12.13.1953.3","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1182\/blood.V87.12.5257.bloodjournal87125257","article-title":"BCL-6 expression during B-cell activation.","volume":"87","author":"Allman","year":"1996","journal-title":"Blood"},{"key":"2021111418545546000_12.13.1953.4","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1002\/j.1460-2075.1996.tb00577.x","article-title":"The SV40 large T antigen and adenovirus E1A oncoproteins interact with distinct isoforms of the transcriptional co-activator p300.","volume":"15","author":"Avantaggiati","year":"1996","journal-title":"EMBO J."},{"key":"2021111418545546000_12.13.1953.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.14.1664"},{"key":"2021111418545546000_12.13.1953.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.5262"},{"key":"2021111418545546000_12.13.1953.7","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","article-title":"LAZ3 rearrangements in non-Hodgkin\u2019s lymphoma: Correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.","volume":"83","author":"Bastard","year":"1994","journal-title":"Blood"},{"key":"2021111418545546000_12.13.1953.8","doi-asserted-by":"publisher","DOI":"10.1042\/bst0250441"},{"key":"2021111418545546000_12.13.1953.9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145","article-title":"BCL-6 protein is expressed in germinal-center B cells.","volume":"86","author":"Cattoretti","year":"1995","journal-title":"Blood"},{"key":"2021111418545546000_12.13.1953.10","first-page":"p175a","article-title":"Downregulation of BCL-6 gene expression by CD40 and EBV latent membrane protein-1 (LMP1) and its block in lymphoma carrying BCL-6 rearrangements. 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