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The Notch signaling pathway is linked to the oscillator and plays a decisive role in inter- and intrasomitic boundary formation. An Fgf8 signaling gradient is involved in somite size control. And the (canonical) Wnt signaling pathway, driven by Wnt3a, appears to integrate clock and gradient in a global mechanism controlling the segmentation process. In this review, we discuss recent advances in understanding the molecular mechanism controlling somitogenesis.<\/jats:p>","DOI":"10.1101\/gad.1217404","type":"journal-article","created":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T17:08:49Z","timestamp":1094058529000},"page":"2060-2067","source":"Crossref","is-referenced-by-count":192,"title":["Segmentation in vertebrates: clock and gradient finally joined"],"prefix":"10.1101","volume":"18","author":[{"given":"Alexander","family":"Aulehla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard G.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"2021111607195874000_18.17.2060.1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9164"},{"key":"2021111607195874000_18.17.2060.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00055-8"},{"key":"2021111607195874000_18.17.2060.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5257.1826"},{"key":"2021111607195874000_18.17.2060.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80212-7"},{"key":"2021111607195874000_18.17.2060.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.596"},{"key":"2021111607195874000_18.17.2060.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(03)00083-2"},{"key":"2021111607195874000_18.17.2060.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2001.00409.x"},{"key":"2021111607195874000_18.17.2060.8","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1092303"},{"key":"2021111607195874000_18.17.2060.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304424"},{"key":"2021111607195874000_18.17.2060.10","first-page":"573","volume":"68","year":"1974","journal-title":"Verh. 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