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However, the C-terminal 70 aa are needed for nuclear localization and a further 50 aa for relocalization into foci. Pol\u03b7 truncations lacking these domains fail to correct the defects in XP-variant cells. Furthermore, we have identified mutations in two XP variant patients that leave the polymerase motifs intact but cause loss of the localization domains.<\/jats:p>","DOI":"10.1101\/gad.187501","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"158-172","source":"Crossref","is-referenced-by-count":258,"title":["Domain structure, localization, and function of DNA polymerase \u03b7, defective in xeroderma pigmentosum variant cells"],"prefix":"10.1101","volume":"15","author":[{"given":"Patricia","family":"Kannouche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard C.","family":"Broughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Volker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon H.F.","family":"Mullenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2001,1,15]]},"reference":[{"key":"2021111507321528000_15.2.158.1","first-page":"926","article-title":"Survey of radiosensitivity in a variety of human cell strains.","volume":"40","author":"Arlett","year":"1980","journal-title":"Cancer Res."},{"key":"2021111507321528000_15.2.158.2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0027-5107(75)90209-2","article-title":"The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet light irradiation.","volume":"33","author":"Arlett","year":"1975","journal-title":"Mutation Res."},{"key":"2021111507321528000_15.2.158.3","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.7.811"},{"key":"2021111507321528000_15.2.158.4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0065-2660(01)43004-5","article-title":"Xeroderma pigmentosum and related disorders: Defects in DNA repair and transcription.","volume":"43","author":"Berneburg","year":"2001","journal-title":"Advances in Genetics"},{"key":"2021111507321528000_15.2.158.5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.4.1549"},{"key":"2021111507321528000_15.2.158.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-189"},{"key":"2021111507321528000_15.2.158.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5334.1996"},{"key":"2021111507321528000_15.2.158.8","first-page":"1102","article-title":"Increased ultraviolet sensitivity and chromosomal instability related to p53 function in the xeroderma pigmentosum variant.","volume":"59","author":"Cleaver","year":"1999","journal-title":"Cancer Res."},{"key":"2021111507321528000_15.2.158.9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13945"},{"key":"2021111507321528000_15.2.158.10","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/MCB.19.3.2206","article-title":"Impaired translesion synthesis in xeroderma pigmentosum extracts.","volume":"19","author":"Cordonnier","year":"1999","journal-title":"Mol. 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