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Having identified the pb locus, we describe the expression of its RNA and protein products. Unlike the other homeotic genes of the ANT-C, pb has no obvious role in embryonic development. Nevertheless, pb protein is detected during embryogenesis in nuclei of the labial and maxillary lobes and in part of the mandibular segment. In this respect, pb expression parallels the early segment-specific expression of neighboring, embryonically essential homeotic genes. Accumulation of pb protein is also detected in mesodermal cells and in a unique subset of nuclei throughout the central nervous system. We also describe a transcription unit very close to pb, which is expressed dorsally during embryogenesis in a pattern resembling that of the nearby zygotic lethal zerkn\u00fcllt (zen) locus. This transcription unit has been shown to contain a homeo box and has been designated z2. Surprisingly, we find that individuals deleted for both the pb and z2 transcription units survive to adulthood and produce normal larval cuticular structures. Thus, pb and z2 show similarities to neighboring ANT-C genes in their expression patterns, yet these similarities are not manifested in comparable loss-of-function embryonic phenotypes.<\/jats:p>","DOI":"10.1101\/gad.2.7.901","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"901-920","source":"Crossref","is-referenced-by-count":106,"title":["The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis."],"prefix":"10.1101","volume":"2","author":[{"given":"M A","family":"Pultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Diederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Cribbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"2021111319471130000_2.7.901.1","unstructured":"Abbott, M.K. 1984. \u201cThe relationship between the structure and function of the Antennapedia locus of Drosophila melanogaster.\u201d PhD. dissertion, Indiana University Bloomington, Indiana."},{"key":"2021111319471130000_2.7.901.2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/genetics\/114.3.919","article-title":"The relationship between the functional complexity and the molecular organization of the Antennapedia locus of Drosophila melanogaster.","volume":"114","year":"1986","journal-title":"Genetics"},{"key":"2021111319471130000_2.7.901.3","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2012.72"},{"key":"2021111319471130000_2.7.901.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.6.1408"},{"key":"2021111319471130000_2.7.901.5","doi-asserted-by":"publisher","DOI":"10.1038\/313545a0"},{"key":"2021111319471130000_2.7.901.6","doi-asserted-by":"publisher","DOI":"10.1038\/327247a0"},{"key":"2021111319471130000_2.7.901.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90818-4"},{"key":"2021111319471130000_2.7.901.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01380474"},{"key":"2021111319471130000_2.7.901.9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90011-X"},{"key":"2021111319471130000_2.7.901.10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90372-7"},{"key":"2021111319471130000_2.7.901.11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/j.1460-2075.1987.tb04820.x","article-title":"Temporal and spatial distribution of transcripts from the Deformed gene of Drosophila.","volume":"6","year":"1987","journal-title":"EMBO J."},{"key":"2021111319471130000_2.7.901.12","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"2021111319471130000_2.7.901.13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1101\/gad.1.1.19","article-title":"The invected gene of Drosophila: Sequence analysis and expression studies reveal a close kinship to the engrailed gene.","volume":"1","year":"1987","journal-title":"Genes Dev."},{"key":"2021111319471130000_2.7.901.14","doi-asserted-by":"crossref","unstructured":"C\u00f4t\u00e9, S., Preiss, A. 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