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Inactivation of both genes causes embryonic lethality, but appeared still compatible with cellular viability. Analysis of<jats:italic>mHR23A\/B<\/jats:italic>double-mutant cells showed that HR23 proteins function in NER by governing XPC stability via partial protection against proteasomal degradation. Interestingly, NER-type DNA damage further stabilizes XPC and thereby enhances repair. These findings resolve the primary function of RAD23 in repair and reveal a novel DNA-damage-dependent regulation mechanism of DNA repair in eukaryotes, which may be part of a more global damage-response circuitry.<\/jats:p>","DOI":"10.1101\/gad.260003","type":"journal-article","created":{"date-parts":[[2003,6,24]],"date-time":"2003-06-24T00:32:32Z","timestamp":1056414752000},"page":"1630-1645","source":"Crossref","is-referenced-by-count":207,"title":["A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein"],"prefix":"10.1101","volume":"17","author":[{"given":"Jessica M.Y.","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbertus T.J.","family":"van der Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bergink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Sugasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Vrieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.J.","family":"Hoeijmakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2003,6,18]]},"reference":[{"key":"2021111519023255000_17.13.1630.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202485699"},{"key":"2021111519023255000_17.13.1630.2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.59"},{"key":"2021111519023255000_17.13.1630.3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100855200"},{"key":"2021111519023255000_17.13.1630.4","doi-asserted-by":"publisher","DOI":"10.1038\/87575"},{"key":"2021111519023255000_17.13.1630.5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.6.1331"},{"key":"2021111519023255000_17.13.1630.6","first-page":"677","volume":"1","year":"2001","journal-title":"The metabolic and molecular bases of inherited disease"},{"key":"2021111519023255000_17.13.1630.7","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.13.4902-4913.2002"},{"key":"2021111519023255000_17.13.1630.8","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve203"},{"key":"2021111519023255000_17.13.1630.9","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.6.1997-2007.2001"},{"key":"2021111519023255000_17.13.1630.10","unstructured":"Friedberg E.C. , Walker, G.C., and Siede, W. 1995. 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