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Moreover, in neural crest cells, TGF\u03b2 signaling is both sufficient and required for phosphorylation of CrkL, a signal adaptor protein implicated in the development of DiGeorge syndrome. Thus, TGF\u03b2 signal modulation in neural crest differentiation might play a crucial role in the etiology of DiGeorge syndrome.<\/jats:p>","DOI":"10.1101\/gad.317405","type":"journal-article","created":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T15:16:40Z","timestamp":1109690200000},"page":"530-535","source":"Crossref","is-referenced-by-count":124,"title":["Inactivation of TGF\u03b2 signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome"],"prefix":"10.1101","volume":"19","author":[{"given":"Heiko","family":"Wurdak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M.","family":"Ittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl S.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Leveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueli","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Born","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2005,3,1]]},"reference":[{"key":"2021111607245070000_19.5.530.1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6566"},{"key":"2021111607245070000_19.5.530.2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","volume":"128","year":"2001","journal-title":"Development"},{"key":"2021111607245070000_19.5.530.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126897.41658.81"},{"key":"2021111607245070000_19.5.530.4","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006"},{"key":"2021111607245070000_19.5.530.5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204779"},{"key":"2021111607245070000_19.5.530.6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280329"},{"key":"2021111607245070000_19.5.530.7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ajmg.a.10980","volume":"119A","year":"2003","journal-title":"Am. 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