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During vulval development, DEP-1 inhibits EGFR signaling in the secondary cell lineage in parallel with the NOTCH-mediated lateral inhibition, while EGFR signaling simultaneously down-regulates DEP-1 and NOTCH expression in the primary cell lineage. This regulatory network of inhibitors results in the full activation of the EGFR\/RAS\/MAPK pathway in the primary vulval cells and at the same time keeps the EGFR\/RAS\/MAPK pathway inactive in the adjacent secondary cells. Mammalian <jats:italic>Dep-1\/Scc1<\/jats:italic> functions as a tumor-suppressor gene in the intestinal epithelium. Thus, mutations in human <jats:italic>Dep-1<\/jats:italic> may promote tumor formation through a hyperactivation of the EGF receptor.<\/jats:p>","DOI":"10.1101\/gad.333505","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:33:32Z","timestamp":1116462812000},"page":"1328-1340","source":"Crossref","is-referenced-by-count":75,"title":["The <i>C. elegans<\/i> homolog of the mammalian tumor suppressor <i>Dep-1\/Scc1<\/i> inhibits EGFR signaling to regulate binary cell fate decisions"],"prefix":"10.1101","volume":"19","author":[{"given":"Thomas A.","family":"Berset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Fr\u00f6hli","family":"Hoier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2005,5,18]]},"reference":[{"key":"2021111607265043000_19.11.1328.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.018"},{"key":"2021111607265043000_19.11.1328.2","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/dev.126.9.1947","volume":"126","year":"1999","journal-title":"Development"},{"key":"2021111607265043000_19.11.1328.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1055642"},{"key":"2021111607265043000_19.11.1328.4","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzg144"},{"key":"2021111607265043000_19.11.1328.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2004.07.007"},{"key":"2021111607265043000_19.11.1328.6","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20031967725"},{"key":"2021111607265043000_19.11.1328.7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","volume":"125","year":"1998","journal-title":"Development"},{"key":"2021111607265043000_19.11.1328.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00021-8"},{"key":"2021111607265043000_19.11.1328.9","doi-asserted-by":"publisher","DOI":"10.1038\/356340a0"},{"key":"2021111607265043000_19.11.1328.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00033-2"},{"key":"2021111607265043000_19.11.1328.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00089-1"},{"key":"2021111607265043000_19.11.1328.12","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.1371\/journal.pbio.0020334","volume":"2","year":"2004","journal-title":"PLoS Biol."},{"key":"2021111607265043000_19.11.1328.13","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1242\/dev.125.18.3667","volume":"125","year":"1998","journal-title":"Development"},{"key":"2021111607265043000_19.11.1328.14","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1544"},{"key":"2021111607265043000_19.11.1328.15","doi-asserted-by":"publisher","DOI":"10.1101\/gad.981602"},{"key":"2021111607265043000_19.11.1328.16","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209019"},{"key":"2021111607265043000_19.11.1328.17","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90377-X"},{"key":"2021111607265043000_19.11.1328.18","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00500"},{"key":"2021111607265043000_19.11.1328.19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067566"},{"key":"2021111607265043000_19.11.1328.20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210194200"},{"key":"2021111607265043000_19.11.1328.21","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.20.2715"},{"key":"2021111607265043000_19.11.1328.22","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.20.7706-7715.2000"},{"key":"2021111607265043000_19.11.1328.23","unstructured":"Hodgkin J . 1997. 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