{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:35Z","timestamp":1791404915158,"version":"4.3.3"},"reference-count":47,"publisher":"Cold Spring Harbor Laboratory","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:p>The transcriptional properties of unliganded thyroid hormone receptors are thought to cause the misdevelopment during hypothyroidism of several functions essential for adult life. To specifically determine the role of unliganded thyroid hormone receptor \u03b11 (TR\u03b11) in neuronal tissues, we introduced a mutation into the mouse TR\u03b11 gene that lowers affinity to thyroid hormone (TH) 10-fold. The resulting heterozygous mice exhibit several distinct neurological abnormalities: extreme anxiety, reduced recognition memory, and locomotor dysfunction. The anxiety and memory deficiencies were relieved by treatment with high levels of TH in adulthood, an effect that correlated with a normalization of GABAergic inhibitory interneurons in the hippocampal CA1 region. In contrast, a post-natal TH treatment was necessary and sufficient for ameliorating the adult locomotor dysfunction. Here, the hormone treatment normalized the otherwise delayed cerebellar development. The data thus identify two novel and distinct functions of an unliganded TR\u03b11 during development and adulthood, respectively.<\/jats:p>","DOI":"10.1101\/gad.346105","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T23:09:10Z","timestamp":1125443350000},"page":"2152-2163","source":"Crossref","is-referenced-by-count":204,"title":["Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor \u03b11 can be ameliorated by T3 treatment"],"prefix":"10.1101","volume":"19","author":[{"given":"C\u00e9sar","family":"Venero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guada\u00f1o-Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella Moreale","family":"de Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Vennstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2005,8,30]]},"reference":[{"key":"2021111607311024000_19.18.2152.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.03.004"},{"key":"2021111607311024000_19.18.2152.2","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.1055\/s-2003-45133","volume":"36","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"2021111607311024000_19.18.2152.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.08.011"},{"key":"2021111607311024000_19.18.2152.4","first-page":"71","volume":"202","year":"2002","journal-title":"Methods Mol. 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