{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:58:04Z","timestamp":1785772684248,"version":"3.56.0"},"reference-count":42,"publisher":"Cold Spring Harbor Laboratory","issue":"15-16","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"crossref","award":["20K07459"],"award-info":[{"award-number":["20K07459"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research on Innovative Areas","award":["19H04820"],"award-info":[{"award-number":["19H04820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"accepted":{"date-parts":[[2026,2,19]]},"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    A zinc finger transcription factor, Bcl11b, is crucial for T-lymphopoiesis. A truncated Bcl11b lacking the C-terminal zinc finger disrupts chromatin accessibility in CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    double-positive thymocytes. Screening chromatin modifiers associated with this zinc finger identified Cxxc1, a component of the Set1 complex mediating H3K4me3.\n                    <jats:italic>Cxxc1<\/jats:italic>\n                    deficiency arrests the CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD8\n                    <jats:sup>\u2212<\/jats:sup>\n                    double-negative-to-double-positive transition, retaining double-negative-like chromatin structure in double-positive thymocytes. Genomic regions bound by Cxxc1 largely overlapped with Bcl11b and were altered upon\n                    <jats:italic>Bcl11b<\/jats:italic>\n                    deficiency. Similar effects are observed in B-lymphocytes via another\n                    <jats:italic>Bcl11<\/jats:italic>\n                    family protein, Bcl11a, highlighting the role of\n                    <jats:italic>Bcl11<\/jats:italic>\n                    family proteins in recruiting Cxxc1 in chromatin modulation during lymphopoiesis.\n                  <\/jats:p>","DOI":"10.1101\/gad.353082.125","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:00:48Z","timestamp":1782421248000},"page":"1214-1226","source":"Crossref","is-referenced-by-count":0,"title":["The Bcl11\u2013Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development"],"prefix":"10.1101","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-9326","authenticated-orcid":false,"given":"Kazuki","family":"Okuyama","sequence":"first","affiliation":[{"name":"Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical 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