{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:11:17Z","timestamp":1789074677288,"version":"build-2803163510"},"reference-count":0,"publisher":"Cold Spring Harbor Laboratory","funder":[{"DOI":"10.13039\/100000002","name":"National Insitutes of Health","doi-asserted-by":"publisher","award":["R01AR079483"],"award-info":[{"award-number":["R01AR079483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Insitutes of Health","doi-asserted-by":"publisher","award":["R56AR085837"],"award-info":[{"award-number":["R56AR085837"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veteran's Administration","award":["I01RX002701"],"award-info":[{"award-number":["I01RX002701"]}]},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015131","name":"Foundation for Sarcoidosis Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015131","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Edwin and Fanny Gray Hall Center for Human Appearance"},{"name":"H.T. Leung Foundation"},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priovant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"abstract":"<jats:p>Noninfectious granulomas organize immune cells into persistent tissue aggregates without an identifiable pathogen. Across diverse diseases, inflammation that should resolve instead persists, producing hallmark pathologic changes in tissue architecture that compromise organ function. Here, we synthesize recent studies to move beyond linear cytokine models and propose that granulomas persist through regulatory circuits linking immune cells, metabolism, and stroma. Maintenance reflects reinforcement among these local programs rather than a single inflammatory pathway. Comparisons across granulomatous diseases, including sarcoidosis, can distinguish disease-specific wiring from conserved maintenance programs. Defining these programs should identify strategies to dismantle established lesions.<\/jats:p>","DOI":"10.1101\/gad.354047.126","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:50:12Z","timestamp":1789073412000},"source":"Crossref","is-referenced-by-count":0,"title":["Regulatory circuits that build and sustain noninfectious granulomas"],"prefix":"10.1101","author":[{"given":"Annika","family":"Ridky","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Rosenbach","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-0824","authenticated-orcid":false,"given":"Thomas H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;"},{"name":"Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2026,9,10]]},"container-title":["Genes &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gad.354047.126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:50:13Z","timestamp":1789073413000},"score":1,"resource":{"primary":{"URL":"http:\/\/genesdev.cshlp.org\/lookup\/doi\/10.1101\/gad.354047.126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":0,"alternative-id":["10.1101\/gad.354047.126"],"URL":"https:\/\/doi.org\/10.1101\/gad.354047.126","relation":{},"ISSN":["0890-9369","1549-5477"],"issn-type":[{"value":"0890-9369","type":"print"},{"value":"1549-5477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}